5α-Pregnane-3α,20α-diol
5α-Pregnane-3α,20α-diol (Allopregnanediol) is a derivative of progesterone and is one of the various steroids secreted by the ovaries of rats. 5α-Pregnane-3α,20α-diol can significantly stimulate the release of luteinizing hormone (LH) in castrated rats that have been pre-treated with estrogen, while simultaneously inhibiting the secretion of follicle-stimulating hormone (FSH).
For research use only. We do not sell to patients.
- CAS No.: 566-58-5
- Formula: C21H36O2
- Molecular Weight:320.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-P0009A
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Luteinizing Hormone Releasing Hormone (LH-RH), salmonLuteinizing Hormone-releasing Hormone -
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FertirelinGnRH Analog -
HY-P1808
LGnRH-III, lampreyGnRH Agonist -
HY-125611
Fluorogestone acetateProgesterone -
HY-W041308R
DCOIT (Standard)Reference Standard -
HY-14789R
(R)-Elagolix (Standard)GnRH Receptor Antagonist
Biological Activity
Description
Chemical Information
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CAS No. 566-58-5
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Molecular Weight 320.51
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Formula C21H36O2
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SMILES
C[C@@]12[C@]3([H])[C@](CC[C@@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@@H](O)C)C
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Synonyms
Allopregnanediol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5α-Pregnane-3α,20α-diol Related Classifications
HY-107850A Related Classifications
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