2. Cell Cycle/DNA Damage
  3. Checkpoint Kinase (Chk)
  4. CHK1-IN-2

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.

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CHK1-IN-2

CHK1-IN-2 화학구조

CAS No. : 912367-45-4

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CHK1-IN-2 Related Antibodies

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제품 설명

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM.

IC50 & Target[1]

Chk1

6 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 GI50
306 nM
Compound: 44
Antiproliferative activity against human MDA-MB-231 cells
Antiproliferative activity against human MDA-MB-231 cells
[PMID: 29301085]
NCI-H460 GI50
2453 nM
Compound: 44
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
Antiproliferative activity against human H460 cells harboring dominant negative p53 construct
[PMID: 29301085]
SW-620 GI50
725 nM
Compound: 44
Antiproliferative activity against human SW620 cells
Antiproliferative activity against human SW620 cells
[PMID: 29301085]
In Vitro

CHK1-IN-2 is a checkpoint kinase 1 (CHK1) inhibitor, with an IC50 of 6 nM, which is a potential cancer therapeutic that can be utilized for enhancing the efficacy of DNA damaging agents[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CHK1-IN-2 Related Antibodies
분자량

366.48

화학식

C20H22N4OS
CAS No.
SMILES

O=C(N)C1=C(SC(C2=CC=CC=C2)=C3)C3=C(N[C@@H]4[C@@H](C)NCCC4)N=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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CHK1-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHK1-IN-2912367-45-4Checkpoint Kinase (Chk)Inhibitorinhibitorinhibit

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상품명:
CHK1-IN-2
Cat. No.:
HY-111369
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