1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)
  3. CHK1-IN-3

CHK1-IN-3 

Cat. No.: HY-128601
Handling Instructions

CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM.

For research use only. We do not sell to patients.

CHK1-IN-3 Chemical Structure

CHK1-IN-3 Chemical Structure

CAS No. : 2097252-39-4

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Description

CHK1-IN-3 is a Checkpoint Kinase 1 (CHK1) inhibitor with an IC50 of 0.4 nM[1].

IC50 & Target[1]

Chk1

0.4 nM (IC50)

In Vitro

CHK1-IN-3 effectively inhibites the growth of malignant hematopathy cell lines especially Z-138 (IC50: 0.013 µM) and displays low affinity for hERG (IC50 > 40 µM)[1].

In Vivo

CHK1-IN-3 significantly suppresses the tumor growth in Z-138 cell inoculated xenograft model as a single agent with body weight unaffected[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

405.46

Formula

C₂₀H₂₃N₉O

CAS No.

2097252-39-4

SMILES

CNC1=C(C2=CN(C)N=C2)C=NC(NC3=CN=C(C#N)C(O[[email protected]]4CNCCC4)=C3)=N1

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CHK1-IN-3
Cat. No.:
HY-128601
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CHK1-IN-3

Cat. No.: HY-128601