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Dimetacrine (Synonyms: Dimethacrine)

Cat. No.: HY-B2075
Handling Instructions

Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression.

For research use only. We do not sell to patients.

Dimetacrine Chemical Structure

Dimetacrine Chemical Structure

CAS No. : 4757-55-5

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Description

Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression.

In Vivo

Dimetacrine is a useful antidepressant which can be used for the treatment of various types of depression. Dimetacrine in the highest concentration, 10 μM, decreases the contractile force to 36.5±9.1%. Dimetacrine, 0.3 μM, causes no statistically significant decline in contractile force from the controls. Tachycardia is observed after the administration of Dimetacrine, 1 to 3 mg/kg i.v., and the maximum response is obtained in dose of 3 mg/kg i.v.. The administration of Dimetacrine, 30 mg/kg i.v., causes an abrupt fall in blood pressure with tachycardia or bradycardia followed by cardiac arrest. Respiratory rate increases 40 min after the onset of infusion of Dimetacrine. Arterial blood pressure falls 50 min after the onset of infusion of Dimetacrine[1].

Molecular Weight

294.43

Formula

C₂₀H₂₆N₂

CAS No.

4757-55-5

SMILES

CN(C)CCCN1C2=CC=CC=C2C(C)(C)C3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[1]

Adult male mongrel dogs weighing 8 to 13 kg are used and anesthetized with sodium pentobarbital, 35 mg/kg i.v. Respiratory movement is measured by an accordion-type pneumograph placed around the thoraco-abdominal region and a pressure transducer. For the experiments on single i.v. injections, the increasing doses of Dimetacrine, 0.1, 0.3, 1, 3, 10 and 30 mg/kg i.v., until cardiac arrest occurs, are given into the cannulated left cephalic vein and are flushed with 1 mL of physiological saline. The changes in arterial blood pressure and heart rate caused by each dose are estimated for IMP, AMT and Dimetacrine[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Dimetacrine
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HY-B2075
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