FASN-IN-4
Based on 3 publication(s) in Google Scholar
FASN-IN-4 is a potent inhibitor of fatty acid synthase (FASN) with an IC50 of 10 nM (WO2012064642A1, compound 29). FASN-IN-4 also inhibits SARS-CoV-2 with an EC50 of 18.6 nM.
For research use only. We do not sell to patients.
- Purity : 99.21%
- CAS No.: 1375105-96-6
- Formula: C26H27N3O4S
- Molecular Weight:477.58
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Publications Citing Use of MedChemExpress (MCE) FASN-IN-4
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Biological Activity
Description
IC50 & Target
In Vitro
The FASN inhibitor, FASN-IN-4 inhibits SARS-CoV-2 replication, and has the potential for COVID-19 research[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1375105-96-6
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Appearance Solid
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Molecular Weight 477.58
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Formula C26H27N3O4S
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Color White to off-white
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SMILES
O=C1COC2(CCN(S(=O)(C3=CC=C(C4=CC=C5C=CC=NC5=C4)C=C3)=O)CC2)CN1C6CC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Metab
2021 Nov;3(11):1466-1475. PMID: 34580494 -
Sci China Life Sci
2022 Feb;65(2):341-361. PMID: 34047913 -
Cell Biosci
Super-enhancer-associated INSM2 regulates lipid metabolism by modulating mTOR signaling pathway in neuroblastoma. [Abstract]2022 Sep 16;12(1):158. PMID: 36114560
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)