1. MAPK/ERK Pathway
  2. Raf
  3. TAK-580

TAK-580 (Synonyms: MLN 2480; BIIB-024)

製品番号: HY-15246 純度: 99.89%
取扱説明書

TAK-580 (MLN 2480) is an orally active and selective inhibitor of pan-Raf kinase.

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TAK-580 構造式

TAK-580 構造式

CAS 番号 : 1096708-71-2

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in DMSO USD 200 在庫あり
Estimated Time of Arrival: December 31
5 mg USD 180 在庫あり
Estimated Time of Arrival: December 31
10 mg USD 312 在庫あり
Estimated Time of Arrival: December 31
50 mg USD 960 在庫あり
Estimated Time of Arrival: December 31
100 mg USD 1680 在庫あり
Estimated Time of Arrival: December 31
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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製品説明

TAK-580 (MLN 2480) is an orally active and selective inhibitor of pan-Raf kinase.

IC50 & Target

RAF

 

体外実験

TAK-580 (MLN 2480) has effect on reversing feedback activation of MEK in response to TAK-733, leading to more concerted MAPK pathway inhibition[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

TAK-580 (MLN 2480) inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinical cancer models at concentrations that are tolerated in vivo. TAK-580 (MLN 2480) is most potent in BRAF mutant melanoma models but also has single agent activity in some RAS mutant models. The combination of MLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than single agent TAK-580 (MLN 2480), including primary human tumor xenograft models of melanoma and CRC[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験
分子量

506.29

分子式

C₁₇H₁₂Cl₂F₃N₇O₂S

CAS 番号

1096708-71-2

SMILES

NC1=NC=NC(C(N[[email protected]@H](C2=NC=C(C(NC3=NC=C(Cl)C(C(F)(F)F)=C3)=O)S2)C)=O)=C1Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (98.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9752 mL 9.8758 mL 19.7515 mL
5 mM 0.3950 mL 1.9752 mL 3.9503 mL
10 mM 0.1975 mL 0.9876 mL 1.9752 mL
*Please refer to the solubility information to select the appropriate solvent.
体内:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.94 mM); Clear solution

*All of the co-solvents are provided by MCE.
参考文献

純度: 99.89%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TAK-580MLN 2480 BIIB-024TAK580TAK 580MLN2480MLN-2480BIIB024BIIB 024BIIB-024RafRaf kinasesInhibitorinhibitorinhibit

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Inquiry Information

製品名:
TAK-580
製品番号:
HY-15246
数量:
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