MM-589

製品番号: HY-100869: Data Sheet 取扱説明書
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MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC₅₀ of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC₅₀ of 12.7 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (MM-589 TFA) usually boasts enhanced water solubility and stability.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

MM-589 構造式

CAS 番号 : 2097887-20-0

容量		在庫状況
MOQ		Minimum order quantity
50 mg		お問い合わせ
100 mg		お問い合わせ
250 mg		お問い合わせ
Other size		お問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other 在庫あり Forms of MM-589:

MM-589 TFA

Other Forms of MM-589:

MM-589 (racemic mixture ) TFA 在庫あり
MM-589 TFA 在庫あり

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•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)^[1]

Ki: <1 nM (WDR5)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	250 nM Compound: MM-589	Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay Anti-proliferative activity against human MV4-11 cells harboring MLL-AF4 fusion protein assessed as cell growth inhibition treated for 4 days by WST-8 cell proliferation assay	[PMID: 35436124]

体外実験

MM-589 (0.01-10 μM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	MV4-11 and MOLM-13 cells
Concentration:	0.01, 0.1, 1, 10 μM
Incubation Time:	4 days or 7 days
Result:	Potently inhibited MV4-11 and MOLM-13 cell growth with IC₅₀s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC₅₀ of 8.6 μM.

分子量

572.70

分子式

C₂₈H₄₄N₈O₅

CAS 番号

2097887-20-0

SMILES

O=C(NCC[C@](NC(C(C)C)=O)(C)C1=O)[C@H](NC([C@@H](NC([C@H](CCCNC(NC)=N)N1)=O)CC)=O)C2=CC=CC=C2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (174.61 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7461 mL	8.7306 mL	17.4611 mL
5 mM	0.3492 mL	1.7461 mL	3.4922 mL
10 mM	0.1746 mL	0.8731 mL	1.7461 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7461 mL	8.7306 mL	17.4611 mL	43.6529 mL
	5 mM	0.3492 mL	1.7461 mL	3.4922 mL	8.7306 mL
	10 mM	0.1746 mL	0.8731 mL	1.7461 mL	4.3653 mL
	15 mM	0.1164 mL	0.5820 mL	1.1641 mL	2.9102 mL
	20 mM	0.0873 mL	0.4365 mL	0.8731 mL	2.1826 mL
	25 mM	0.0698 mL	0.3492 mL	0.6984 mL	1.7461 mL
	30 mM	0.0582 mL	0.2910 mL	0.5820 mL	1.4551 mL
	40 mM	0.0437 mL	0.2183 mL	0.4365 mL	1.0913 mL
	50 mM	0.0349 mL	0.1746 mL	0.3492 mL	0.8731 mL
	60 mM	0.0291 mL	0.1455 mL	0.2910 mL	0.7275 mL
	80 mM	0.0218 mL	0.1091 mL	0.2183 mL	0.5457 mL
	100 mM	0.0175 mL	0.0873 mL	0.1746 mL	0.4365 mL

MM-589 Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM-5892097887-20-0MM589MM 589WDR5WD repeat protein-5WD40 repeat domain protein 5Inhibitorinhibitorinhibit

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