2. PROTAC Stem Cell/Wnt Metabolic Enzyme/Protease
  3. Molecular Glues β-catenin E1/E2/E3 Enzyme
  4. NRX-252262

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM.

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NRX-252262

NRX-252262 Estructura química

No. CAS : 2438637-61-5

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  

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NRX-252262 Related Antibodies

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Descripciòn

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation, with an EC50 of 3.8 nM[1].

IC50 & Target

EC50: 3.8 nM (β-Catenin-SCFβ-TrCP)[1]
In Vitro

NRX-252262 (35 μM) causes S33E/S37A mutant β-catenin degradation in cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NRX-252262 Related Antibodies
Peso molecular

545.36

Fòrmula

C23H17Cl2F3N2O4S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C(N2CC(C=C(OC)C(OC)=C3)=C3C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

DMSO : 8.33 mg/mL (15.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8337 mL 9.1683 mL 18.3365 mL
5 mM 0.3667 mL 1.8337 mL 3.6673 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8337 mL 9.1683 mL 18.3365 mL 45.8413 mL
5 mM 0.3667 mL 1.8337 mL 3.6673 mL 9.1683 mL
10 mM 0.1834 mL 0.9168 mL 1.8337 mL 4.5841 mL
15 mM 0.1222 mL 0.6112 mL 1.2224 mL 3.0561 mL
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NRX-252262 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NRX-2522622438637-61-5NRX252262NRX 252262Molecular Gluesβ-cateninE1/E2/E3 EnzymeBeta cateninE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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Nombre del producto:
NRX-252262
Cat. No.:
HY-111760
Cantidad:
MCE Japan Authorized Agent:

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