Porcine dynorphin A(1-13)
Based on 1 Customer Validation
Porcine dynorphin A (1-13) is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations.
For research use only. We do not sell to patients.
- Purity: 99.86%
- CAS No.: 72957-38-1
- Formula: C75H126N24O15
- Molecular Weight:1603.95
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Opioid Receptor Isoforms
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Biological Activity
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κ Opioid Receptor/KOR |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
18 nM
Compound: Dynorphin A(1-13)
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Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells
Binding affinity towards k-opioid receptor k-EL-2 mutant (wild-type) expressed in HEK cells
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[PMID: 10753461] |
| HEK293 | EC50 |
6 nM
Compound: Dynorphin A(1-13)
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Binding affinity towards Mutant E203Q,D204N,D206N Opioid receptor kappa 1 expressed in HEK cells
Binding affinity towards Mutant E203Q,D204N,D206N Opioid receptor kappa 1 expressed in HEK cells
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[PMID: 10753461] |
| HEK293 | EC50 |
8 nM
Compound: Dynorphin A(1-13)
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Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 expressed in HEK cells
Binding affinity towards Mutant D216N, D217N, E218Q Opioid receptor kappa 1 expressed in HEK cells
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[PMID: 10753461] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 72957-38-1
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Appearance Solid
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Molecular Weight 1603.95
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Formula C75H126N24O15
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Color White to off-white
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Synonyms
Dynorphin A Porcine Fragment 1-13
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Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys
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Sequence Shortening
YGGFLRRIRPKLK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : ≥ 50 mg/mL (31.17 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (62.35 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6235 mL | 3.1173 mL | 6.2346 mL | 15.5865 mL |
| 5 mM | 0.1247 mL | 0.6235 mL | 1.2469 mL | 3.1173 mL | |
| 10 mM | 0.0623 mL | 0.3117 mL | 0.6235 mL | 1.5587 mL | |
| 15 mM | 0.0416 mL | 0.2078 mL | 0.4156 mL | 1.0391 mL | |
| 20 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
| 25 mM | 0.0249 mL | 0.1247 mL | 0.2494 mL | 0.6235 mL | |
| 30 mM | 0.0208 mL | 0.1039 mL | 0.2078 mL | 0.5196 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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