Inflammation/Immunology

Guaiacol-d₇ is the deuterium labeled Guaiacol. Guaiacol, a phenolic compound, inhibits LPS-stimulated COX-2 expression and NF-κB activation. Anti-inflammatory activity.

Tilmicosin (phosphate) (Standard) is the analytical standard of Tilmicosin (phosphate). This product is intended for research and analytical applications. Tilmicosin (LY-177370) phosphate is an orally active calcium channel antagonist and macrolide antibiotic with antimicrobial activity. Tilmicosin phosphate mainly acts on the 50S subunit of bacterial ribosomes, inhibiting protein synthesis. Tilmicosin phosphate is effective in the treatment of respiratory diseases in livestock such as cattle, sheep and pigs. In addition, Tilmicosin phosphate has immunomodulatory and anti-inflammatory effects.

Moldapyranone A (formula I) is a pyrone compound with a significant effect on up-regulating the expression of KLF2. Moldapyranone A can be used for the study of cardiovascular disease or anti-inflammatory.

GLP-1 receptor agonist 22 is an orally active GLP-1 receptor agonist. GLP-1 receptor agonist 22 promotes the accumulation of cAMP. GLP-1 receptor agonist 22 reduces blood glucose levels and inhibits feeding behavior in human glucagon-like peptide-1 receptor knock-in mice. GLP-1 receptor agonist 22 can be used in the research of type 2 diabetes and obesity.

Anti-USAG-1 Antibody is a monoclonal antibody that targets SOSTDC1. Anti-USAG-1 Antibody can be used in ELISA, FACS, and functional assays.

BIRT2584 is an LFA-1 inhibitor. BIRT2584 can be used for research on autoimmune diseases.

Arnica montana extract has analgesic and anti-inflammatory properties.

MOG peptide (79-96) rat is a myelin oligodendrocyte glycoprotein (MOG) with encephalitogenic effects.

Soulattrolide is a non-nucleoside HIV-1 reverse transcriptase (RT) inhibitor with IC₅₀ values of 0.34 µM for HIV-1 RT, 69.5 µM for E. coli RNase H, and >495 µM for human DNA polymerase β, and can be found in Calophyllum teysmannii latex. Soulattrolide can be used for the research of HIV-1 infection, pain, inflammation, and Mycobacterium tuberculosis infection.

13(R),14(R)-epoxy Fluprostenol isopropyl ester is a Prostaglandin derivative.

CCR5-IN-1 (compound 3ad) is a selective allosteric CCR5 inhibitor with an IC₅₀ of 1.09 μM. CCR5-IN-1 can be used in the study of cardiovascular, central nervous system, immune system, and infectious diseases.

Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting.

CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC₅₀ of 0.75 nM.

Paranyline is a novel anti-inflammatory treatment specifically designed for arthritis.

HIV gp120 254-274 is a conserved fragment in envelope glycoprotein gp120 of human immunodeficiency virus (HIV), and exhibits immunosilent activity.

smMLCK peptide is a specific inhibitor of smooth muscle myosin light chain kinase (smMLCK). The smMLCK peptide mimics the substrate and competitively inhibits the binding of the actual substrate to the enzyme, thereby inhibiting the kinase activity. This inhibition prevents the phosphorylation of the myosin light chain, thus inhibiting muscle contraction.

Alkyne-GRWHPM-CONH-NH-CMK is a covalent Cathepsin S inhibitor (IC₅₀=82 nM). Alkyne-GRWHPM-CONH-NH-CMK has an N-terminal alkyne handle for CuAAC functionalization that engages off-target protein disulfide isomerase PDIA1. Alkyne-GRWHPM-CONH-NH-CMK can be used for the research of autoimmune disorders.

Tiaramide is an anti-inflammatory agent. Tiaramide inhibits the PGE2 release. Tiaramide inhibits the rise in intracellular free Ca²⁺ induced by PGE2 (HY-101952) as well as Bradykinin (HY-P0206). Tiaramide inhibites Bradykinin-induced contraction.

RXFP1 receptor agonist-1 (Example 2 peak2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-1 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC₅₀ value of 300 nM.