Inflammation/Immunology

CT-1119 is an autologous human anti-Mesothelin chimeric antigen receptor macrophage (CAR-M). CT-1119 mediates CAR-dependent, antigen-dependent functional activities. CT-1119 acts as a phagocytosis inducer, tumor cell killer, pro-inflammatory cytokine inducer, and M1 macrophage polarizer. CT-1119 exhibits stronger resistance to M2 repolarization and reduces tumor burden in a mouse lung cancer xenograft model. CT-1119 can be used for the research of mesothelin-expressing solid tumors.

2,2,5,7,8-Pentamethyl-6-Chromanol (Standard) is the analytical standard of 2,2,5,7,8-Pentamethyl-6-Chromanol. This product is intended for research and analytical applications. 2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines[1].

NF-κB-IN-21 is a NF-κB signaling pathway inhibitor. NF-κB-IN-21 reduces the phosphorylation levels of IκBα and p65, and inhibits the nuclear translocation of p65. NF-κB-IN-21 downregulates the expression of iNOS, inhibits nitric oxide production, and decreases the levels of pro-inflammatory cytokines TNF-α and IL-6. NF-κB-IN-21 is used in the research of inflammatory diseases.

Anti-BMP-4 Antibody is an antibody against human BMP-4. Recommend Isotype Controls:?Human IgG1 kappa, Isotype Control (HY-P99001).

Anti-CCR1 Antibody is an antibody against human CCR1/CD191. Recommend Isotype Controls:?Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

Ketoprofen (lysinate) (Standard) is the analytical standard of Ketoprofen (lysinate). This product is intended for research and analytical applications. Ketoprofen (RP-19583) lysinate is a non-steroidal anti-inflammatory agent. Ketoprofen lysinate can inhibit the activity of cyclooxygenase with IC50 values of 2 nM (COX-1) and 26 nM (COX-2). which is potential in the research of inflammation, immunology, and metabolic disease such as obesity.

Aristolochic acid D (Standard) (Aristolochic acid-IVa (Standard)) is the analytical standard of Aristolochic acid D (HY-N1465). This product is intended for research and analytical applications. Aristolochic acid D (Aristolochic acid-IVa) is an orally active PDE2 (IC₅₀: 4.673 μM) and CDK2 (IC₅₀: 25 μM) inhibitor that can be isolated from Aristolochia indica L. Aristolochic acid D exhibits anti-inflammatory activity and is non-carcinogenic and non-nephrotoxic. Aristolochic acid D can be used in the research of inflammation and tumor-related diseases.

VHH human IgG4 Fc, Isotype Control is an isotype control for VHH human IgG4 Fc.

Polygonolide is an orally active isocoumarin anti-inflammatory agent. Polygonolide is present in the roots of Polygonum hydropiper and Persicaria hydropiper. Polygonolide inhibits the reversed passive Arthus reaction in rats. Polygonolide can be used in studies related to immune complex-induced inflammation.

HPA-IN-3 (compound 5) is a heparanase (HPA) inhibitor with an IC₅₀ of 11.27 μM against human targets. HPA-IN-3 binds to the active site of HPA, and its structural features enhance binding stability and affinity. HPA-IN-3 reduces the levels of proinflammatory cytokines. HPA-IN-3 maintains organ morphology. HPA-IN-3 improves the survival rate of mice with sepsis induced by cecal ligation and puncture. HPA-IN-3 can be used in studies related to sepsis.

Agazisiran, a siRNA,is a complement factor B synthesis reducer.

Ractopamine/BSA is an antigen-adjuvant conjugate formed by the conjugation of Ractopamine (HY-113781) with Bovine Serum Albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.

Antibacterial agent 57 (example 25) is a antibacterial agent (extracted from patent WO2013030735A1).

Anti-AGR2 Antibody is a monoclonal antibody that targets AGR2. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-AGR2 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

J5 peptide is an MBP inhibitor that competitively inhibits the binding of MBP_85-99 to HLA-DR2. J5 peptide alleviates PLP_139-151/MBP_85-99-induced experimental autoimmune encephalomyelitis (EAE) in mice. J5 peptide can be used in research on inflammatory and immune diseases.

Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Na_v1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

Laporolimus (CRC-015d) is a macrocyclic triene immunosuppressant that binds to serum albumins (HSA (HY-P1956)/BSA (HY-D0842)).

Rabeximod (ROB-803), an anti-rheumatic compound, impairs the differentiation and function of human pro-inflammatory dendritic cells and macrophages via downregulating TLR2 and TLR4 stimulation. Rabeximod (ROB-803) is used for rheumatoid arthritis (RA) research.

COX-2/LOX-IN-2 (compound 6) is a dual inhibitor of COX-2/LOX with IC₅₀s of 7.0 μM and 27.5 μM, respectively. COX-2/LOX-IN-2 has antioxidant activity and has the potential to be used in the development of nonsteroidal anti-inflammatory drugs (tNSAIDs).

ZJK-807 is a highly efficient and selective KRAS^G12D PROTAC degrader (DC₅₀ = 79.5 nM in AsPC-1 cells). ZJK-807 promotes KRAS^G12D ubiquitination and degradation. ZJK-807 suppresses RAS/MAPK signaling and uniquely modulates TNF signaling and eukaryotic ribosome biogenesis. ZJK-807 can be used for the study of KRAS-driven pancreatic cancer.