country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N19101

Copy Link Print Information

Polygonolide

Polygonolide is an orally active isocoumarin anti-inflammatory agent. Polygonolide is present in the roots of Polygonum hydropiper and Persicaria hydropiper. Polygonolide inhibits the reversed passive Arthus reaction in rats. Polygonolide can be used in studies related to immune complex-induced inflammation.

For research use only. We do not sell to patients.

CAS No.: 100560-66-5
Formula: C₁₂H₁₂O₄
Molecular Weight:220.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Polygonolide Chemical Structure

CAS No.: 100560-66-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

Polygonolide (100 mg/kg; p.o.; single dose) inhibits the rat reversed passive Arthus reaction by 39.2%^[1].
Polygonolide (100 mg/kg; p.o.; single dose) inhibits 39.2% of acute inflammation induced by the reversed passive Arthus reaction in rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Albino rats^[1]
Dosage:

100 mg/kg
Administration:

p.o.; single dose
Result:

Inhibited the reversed passive Arthus reaction by 39.2%.

Chemical Information

CAS No. 100560-66-5
Molecular Weight 220.22
Formula C₁₂H₁₂O₄
SMILES

O=C1OC(=C(C=2C=C(OC)C=C(O)C12)C)C
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Furuta T, et al. Polygonolide, an isocoumarin from Polygonum hydropiper possessing anti-inflammatory activity[J]. Phytochemistry, 1986, 25(2): 517-520.

[2]. Huq AK, et al. Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects of Persicaria hydropiper (L.) Delarbre. Evidence-based complementary and alternative medicine : eCAM. 2014;2014:782830. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote