Inflammation/Immunology

Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC₅₀ of ∼5 and ∼6.5 μM.

Antibacterial agent 76 (compound 9) is an antibacterial agent.

IL-17-IN-5 (Compound 3) is an IL-17 inhibitor with an IC₅₀ of <0.1 μM. IL-17-IN-5 can be used in the research of inflammatory diseases.

Anti-IL-31 Antibody is a monoclonal antibody that targets IL-31. Anti-IL-31 Antibody can be used in ELISA, FACS, and functional assays.

2,4-Dihydroxybenzaldehyde (Standard) is the analytical standard of 2,4-Dihydroxybenzaldehyde. This product is intended for research and analytical applications. 2,4-Dihydroxybenzaldehyde is an endogenous metabolite.

Triforine (CELA W 524), a systemic fungicide, was shown to display a moderate to distinct fungitoxic activity in vitro towards several pathogenic and non-pathogenic fungi.

AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing.

CXCR4 modulator-1 (compound ZINC72372983) is a potent CXCR4 modulator with an EC₅₀ value of 100 nM. CXCR4 modulator-1 can be used for researching anti-inflammatory, anticancer and anti-HIV.

DPQ hydrochloride is a blood-brain barrier permeable and selective PARP-1 inhibitor that blocks PARP-1-mediated DNA damage repair and NAD⁺/ATP consumption, thereby inhibiting excessive inflammatory responses. DPQ hydrochloride inhibits NF-κB pathway activation, reduces the expression of pro-inflammatory factors (such as TNF-α, IL-6) and oxidative stress. DPQ hydrochloride can be used in inflammation-related studies of acute lung injury, myocardial infarction, and neurodegenerative diseases.

DMG-PEG5000-WYRGRL is a functionalized PEGylated lipid conjugate composed of three modular components: dimyristoylglycerol (DMG) as the lipid anchoring group, a polyethylene glycol (PEG) spacer arm with a molecular weight of 5000 Da, and WYRGRL peptide (HY-P10739)as the terminal targeting/functional ligand. DMG-PEG5000-WYRGRL can be incorporated into liposomes, lipid nanoparticles (LNPs), or other nanocarriers to confer ligand-directed targeting capability against specific cell surface receptors in tumor and inflammatory microenvironments.

The Anti-PMEL Antibody is a human-derived antibody expressed in CHO cells, targeting PMEL. The Anti-PMEL Antibody contains a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.54 kDa. The isotype control for the Anti-PMEL Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

NLRP3-IN-31 (Comp 14) is a NLRP3 inhibitor, with an IC₅₀ of 0.3-0.5 μM.

Olsalazine (Standard) is an orally active prodrug of 5-ASA (HY-15027). Olsalazine (Standard) can inhibit cells proliferation and induce apoptosis. Olsalazine (Standard) can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine (Standard) can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.

NCGC00135472 is a potent agonist of resolvin D1 receptor (DRV1), with the EC₅₀ of 0.37 nM and 0.05 μM for β-arrestin and cAMP activities, respectively.

Highly purified Type II collagen, from sheep articular cartilage (Sheep Type II collagen, immunization grade) is an immune grade collagen derived from sheep articular cartilage, which can stimulate the animal's immune system to produce specific antibodies against this collagen. Collagen is also a substrate for hydrolysis by MMPs.

8-Acetyl-9-hydroxy-3-methoxy-7-methyl-1-phenalenon is a phenalenone derivative found in the aerial parts of Helicteres angustifolia. 8-Acetyl-9-hydroxy-3-methoxy-7-methyl-1-phenalenon exhibits moderate anti-complement activity against the classical pathway and weak activity against the alternative pathway.

Lynestrenol (Standard) is the analytical standard of Lynestrenol. This product is intended for research and analytical applications. Lynestrenol is a pregnane X receptor (PXR) agonist with the EC50s of 41 and 0.23 μM for hPXR and zfPXR, respectively. Lynestrenol, a synthetic progesteronelike agent possess immunostimulatory properties.

Anti-IL-12RB2 Antibody is an anti-IL-12RB2 antibody. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

Chinoin 127 is a non anesthetic analgesic agent with strong anti-inflammatory activity. Chinoin 127 shows potent analgesic effect in the hot plate test, Randall Selitto test, and torsion test.

Magnoliae flos extract (Magnolia liliflora extract) is an extract of Flos Magnoliae, which can be used in research on allergic rhinitis, sinusitis, etc.