1642113-59-4
Chemical Structure
AM-0466
- CAS No.: 1642113-59-4
- Formula:C27H19F3N4O4S
- Molecular Weight:552.52
IUPAC Name: 1-(3-methoxy-3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-2-oxo-N-(pyrimidin-2-yl)-1,2-dihydroquinoline-6-sulfonamide
InChIKey: HSOCYPPAQYZHMJ-UHFFFAOYSA-N
SMILES: O=C1N(C2=C(OC)C=C(C=C2)C3=CC(C(F)(F)F)=CC=C3)C4=CC=C(S(=O)(NC5=NC=CC=N5)=O)C=C4C=C1
Biological Activity: AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing[1].
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AM-0466 | AM-0466 is a sodium channel inhibitor with nanomolar levels of NaV1.7 inhibitory activity. AM-0466 exhibits potent pharmacodynamic activity in a NaV1.7-dependent histamine-induced itch model. AM-0466 also showed significant analgesic effects in capsaicin-induced pain models. After optimizing its pharmacokinetic properties, AM-0466 was advanced into in vivo targeting and efficacy models for testing. | |||||||||||||||||||||
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Keywords
