2828433-23-2
2828433-23-2
Chemical Structure
Gly-Arg-Gly-Asp-Ser TFA
Synonym(s): GRGDS TFA
- CAS No.: 2828433-23-2
- Formula:C19H31F3N8O11
- Molecular Weight:604.49
InChIKey: ZLLSDISMWHMSOI-PUBMXKGKSA-N
SMILES: O=C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O)CN.OC(C(F)(F)F)=O
Biological Activity: Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin[1]. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM[2].
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Gly-Arg-Gly-Asp-Ser TFA | Gly-Arg-Gly-Asp-Ser (TFA) is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC50 of ∼5 and ∼6.5 μM. | |||||||||||||||||||||
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References
- [1]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9. [Content Brief]
- [2]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997. [Content Brief]
Keywords
