Cat. No.: HY-17031

SBE-β-CD

Name: SBE-β-CD
Brand: MedChemExpress
SKU: HY-17031
Price: 50.00 USD
Availability: InStock
Rating: 5 (167 reviews)

(Synonyms: Sulfobutylether-β-Cyclodextrin)

167 Cited Publications

Customer Review

Based on 167 publication(s) in Google Scholar

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents.

For research use only. We do not sell to patients.

Purity : 99.89%
CAS No.: 182410-00-0
Molecular Weight:2083-2257

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SBE-β-CD Chemical Structure

CAS No.: 182410-00-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Publications (167)
Solvent & Solubility
- In Vitro
Purity & Documentation
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Biological Activity

Description

SBE-β-CD is a sulfobutylether β-cyclodextrin derivative used as an excipient or a formulating agent to increase the solubility of poorly soluble agents^[1].

In Vitro

SBE-β-CD is a chemically modified β-CD that is a cyclic hydrophilic oligosaccharide which is negatively charged in aqueous media. β-CD functioned is a solubilizer only at low concentrations, whereas SBE7-β-CD exhibits strong solubilizing effects over a wide concentration range^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

20% SBE-β-CD in saline:
Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Dissolve 0.9 g of NaCl in 100 mL distilled water to make a clear 0.9% saline solution.
2. Measure 2 g of dry SBE-β-CD.
3. Dissolve 2 g of SBE-β-CD in 0.9% saline to make 10 mL with a 20% (w/v) concentration. These may require ultrasonic (20-40 kHz, 30 seconds, repeat 3 times) or heating (37°C for about 30 minutes). If precipitation is observed, the precipitates can be dissolved by heating to 37°C and vortexing before use.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 182410-00-0
Appearance Solid
Molecular Weight 2083-2257
Color White to off-white
SMILES

[R]O[C@@H]1[C@H](O[R])[C@H](O[C@@H]2[C@H](O[R])C(O[R])[C@H](O3)[C@@H](CO[R])O2)[C@@H](CO[R])O[C@@H]1O[C@H]4[C@H](O[R])[C@@H](O[R])[C@@H](O[C@H]5[C@H](O[R])[C@@H](O[R])[C@@H](O[C@@H]6C(O[R])[C@H](O[R])[C@H](O[C@@H]7[C@@H](O[R])[C@H](O[R])[C@H](O[C@@H]8[C@@H](O[R])[C@H](O[R])[C@H]3O[C@H]8CO[R])O[C@H]7CO[R])O[C@H]6CO[R])O[C@@H]5CO[R])O[C@@H]4CO[R].[R= H 21-m or C4H8SO3-Na+ m , m=6.0-7.1]
Synonyms

Sulfobutylether-β-Cyclodextrin
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (167)

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Nature

Critical role for a high-plasticity cell state in lung cancer. [Abstract]

2026 Mar;651(8104):231-241. PMID: 41565826
Nature

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis. [Abstract]

2025 Jan;637(8044):184-194. PMID: 39633048
Cancer Cell

Elevated CXorf67 Expression in PFA Ependymomas Suppresses DNA Repair and Sensitizes to PARP Inhibitors. [Abstract]

2020 Dec 14;38(6):844-856.e7. PMID: 33186520
Nat Med

MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. [Abstract]

2017 Jun;23(6):723-732. PMID: 28394332
Cell

Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. [Abstract]

2021 Jul 22;184(15):4032-4047.e31. PMID: 34171309
Immunity

Nonsense-mediated mRNA decay inhibition reshapes the cancer immunopeptidome. [Abstract]

2026 May 12;59(5):1398-1421.e20. PMID: 41956098
Immunity

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis. [Abstract]

2025 May 22:S1074-7613(25)00221-3. PMID: 40449484
Cancer Discov

Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC Model. [Abstract]

2025 Jan 13;15(1):162-178. PMID: 39348506
Nat Immunol

Tissue-resident exhausted and memory CD8+ T cells have distinct ontogeny, function and role in disease. [Abstract]

2026 Jan;27(1):110-125. PMID: 41461986
Cell Stem Cell

Mitochondrial serine catabolism safeguards maintenance of the hematopoietic stem cell pool in homeostasis and injury. [Abstract]

2024 Oct 3;31(10):1484-1500.e9. PMID: 39181130
Cancer Res

SPINK6 Promotes Metastasis of Nasopharyngeal Carcinoma via Binding and Activation of Epithelial Growth Factor Receptor. [Abstract]

2017 Jan 15;77(2):579-589. PMID: 27671677
Nat Microbiol

Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4+ T cell interactions and infection control. [Abstract]

2026 Jun;11(6):1677-1695. PMID: 41933199
Nat Commun

Targeting de novo pyrimidine synthesis confers vulnerability to copper-mediated ATR inactivation in PARP inhibitor-resistant ovarian cancer. [Abstract]

2026 Feb 25;17(1):3142. PMID: 41735312
Nat Commun

RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity. [Abstract]

2025 Sep 17;16(1):8287. PMID: 40962798
Nat Commun

A germline-to-soma signal triggers an age-related decline of mitochondrial stress response. [Abstract]

2024 Oct 8;15(1):8723. PMID: 39379393
Nat Commun

Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability. [Abstract]

2024 Mar 16;15(1):2377. PMID: 38493213
Nat Commun

Multigenerational paternal obesity enhances the susceptibility to male subfertility in offspring via Wt1 N6-methyladenosine modification. [Abstract]

2024 Feb 14;15(1):1353. PMID: 38355624
Nat Commun

Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis. [Abstract]

2023 Oct 18;14(1):6584. PMID: 37852976
Nat Commun

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. [Abstract]

2019 Jul 1;10(1):2901. PMID: 31263101
Nat Commun

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. [Abstract]

2018 Jun 29;9(1):2547. PMID: 29959321
Metabolism

Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus. [Abstract]

2018 May:82:88-99. PMID: 29366755
Sci Transl Med

Small-molecule screen reveals synergy of cell cycle checkpoint kinase inhibitors with DNA-damaging chemotherapies in medulloblastoma. [Abstract]

2021 Jan 20;13(577):eaba7401. PMID: 33472956
Theranostics

Promising alternatives of CD47 monoclonal antibody: an injectable degradable hydrogel loaded with PQ912 for postoperative immunotherapy effectively blocks CD47-SIRPα signal. [Abstract]

2022 May 27;12(10):4581-4598. PMID: 35832081
Theranostics

Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy. [Abstract]

2019 Nov 26;9(26):8426-8436. PMID: 31879528
J Clin Invest

PROX1 is an early driver of lineage plasticity in prostate cancer. [Abstract]

2025 Jun 2;135(11):e187490. PMID: 40454483
J Exp Clin Cancer Res

Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia. [Abstract]

2024 Jul 24;43(1):205. PMID: 39044280
J Exp Clin Cancer Res

Elafin promotes tumour metastasis and attenuates the anti-metastatic effects of erlotinib via binding to EGFR in hepatocellular carcinoma. [Abstract]

2021 Mar 26;40(1):113. PMID: 33771199
Adv Sci (Weinh)

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury. [Abstract]

2026 Jun;13(34):e22891. PMID: 41904943
Adv Sci (Weinh)

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation. [Abstract]

2025 Oct 5:e03576. PMID: 41047470
Adv Sci (Weinh)

A Novel Cranial Bone Transport Technique Repairs Skull Defect and Minimizes Brain Injury Outcome in Traumatic Brain Injury Rats. [Abstract]

2025 Aug;12(32):e04467. PMID: 40448603
Adv Sci (Weinh)

Hybrid Electro-optical Stimulation Improves Ischemic Brain Damage by Augmenting the Glymphatic System. [Abstract]

2025 Apr;12(13):e2417449. PMID: 39927473
Adv Sci (Weinh)

STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity. [Abstract]

2023 Jan;10(3):e2203718. PMID: 36445063
Alzheimers Dement

Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function. [Abstract]

2025 Feb;21(2):e14518. PMID: 39887820
Chem Eng J

2025 Oct 8;524:169421.
Cancer Lett

A novel Smac mimetic APG-1387 demonstrates potent antitumor activity in nasopharyngeal carcinoma cells by inducing apoptosis. [Abstract]

2016 Oct 10;381(1):14-22. PMID: 27424523
Phytomedicine

Motherwort synergized with oxytocin for postpartum hemorrhage prevention: Integrated clinical efficacy and mechanism exploration. [Abstract]

2025 Sep:145:156951. PMID: 40527062
Acta Pharmacol Sin

A FAPI-based small-molecule drug conjugate alleviates rheumatoid arthritis by targeting pathogenic FAPα-expressing fibroblasts. [Abstract]

2026 Jan 1. PMID: 41478880
Cell Death Discov

Berberine alleviates liver fibrosis through inducing ferrous redox to activate ROS-mediated hepatic stellate cells ferroptosis. [Abstract]

2021 Dec 4;7(1):374. PMID: 34864819
Proc Natl Acad Sci U S A

Androgen receptors in corticotropin-releasing hormone neurons mediate the sexual dimorphism in restraint-induced thymic atrophy. [Abstract]

2025 Mar 25;122(12):e2426107122. PMID: 40106355
BME Front

Quantifying Spatiotemporal Heterogeneity of Tumor Metabolism and Vasculature with a Multiparametric Point-of-Investigation Microscope. [Abstract]

2025 Dec 9:6:0207. PMID: 41377143
Int J Biol Macromol

Exploiting an evolutionary constraint: Targeting TatD nuclease with chrysosplenol D disrupts Mycoplasma gallisepticum infection. [Abstract]

2025 Jul 29;321(Pt 3):146394. PMID: 40744178
Int J Nanomedicine

Viral Mimetic Bacterial Outer Membrane Vesicles for Targeting Angiotensin-Converting Enzyme 2. [Abstract]

2025 Jan 16:20:669-684. PMID: 39835181
Int J Biol Macromol

Jun and JunB members of the AP-1 complex are potential therapeutic targets for silicosis. [Abstract]

2024 Oct;277(Pt 1):134024. PMID: 39032899
Mol Ther Oncol

2025 Dec 9.
Mol Med

Correction: Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. [Abstract]

2026 Feb 28;32(1):32. PMID: 41764431
Mol Med

Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2. [Abstract]

2025 Jun 11;31(1):234. PMID: 40500698
Phytother Res

Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease. [Abstract]

2023 Feb;37(2):611-626. PMID: 36325883
Cancer Immunol Res

Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer. [Abstract]

2026 May 28. PMID: 42207977
Cancer Immunol Res

Chemotherapy Induces Tumor-Associated Macrophages that Aid Adaptive Immune Responses in Ovarian Cancer. [Abstract]

2021 Jun;9(6):665-681. PMID: 33839687
Br J Cancer

Targeting epidermal growth factor receptor in paclitaxel-resistant human breast and lung cancer cells with upregulated glucose-6-phosphate dehydrogenase. [Abstract]

2022 Sep;127(4):661-674. PMID: 35597872
Cell Rep

Blocking glycogen synthase 1 in white adipose tissue alleviates hypermetabolism following severe burn injury through inhibition of JAK2 by UDPG. [Abstract]

2025 Nov 18;44(12):116577. PMID: 41259203
Cell Rep

AMPK activation protects against prostate cancer by inducing a catabolic cellular state. [Abstract]

2023 Apr 15;42(4):112396. PMID: 37061917
Cell Rep

Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors. [Abstract]

2020 Nov 17;33(7):108395. PMID: 33207205
Cell Rep

Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy. [Abstract]

2019 Oct 8;29(2):249-257.e8. PMID: 31597089
Cell Prolif

Cellular senescence mediates retinal ganglion cell survival regulation post-optic nerve crush injury. [Abstract]

2024 Dec;57(12):e13719. PMID: 39021340
Transl Psychiatry

Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization. [Abstract]

2023 Oct 6;13(1):310. PMID: 37802998
Br J Pharmacol

Transient receptor potential vanilloid 4 channel regulates vascular endothelial permeability during colonic inflammation in dextran sulphate sodium-induced murine colitis. [Abstract]

2018 Jan;175(1):84-99. PMID: 29053877
Cell Mol Neurobiol

Activation of the Reverse Cholesterol Transport Pathway: A Strategy to Ameliorate Lipid Metabolic Dyshomeostasis in the Microenvironment Following Spinal Cord Injury. [Abstract]

2026 Jun 19. PMID: 42321551
Int J Radiat Oncol Biol Phys

Radiation Induces Pericyte-Myofibroblast Transition. [Abstract]

2025 Jun 16:S0360-3016(25)03903-3. PMID: 40532892
Int J Oncol

Bevacizumab counteracts VEGF-dependent resistance to erlotinib in an EGFR-mutated NSCLC xenograft model. [Abstract]

2017 Aug;51(2):425-434. PMID: 28627678
Pharmaceutics

The Activity of FDA-Approved Prodrug Isavuconazonium Sulfate and Its Major Metabolite Isavuconazole Against Naegleria fowleri. [Abstract]

2026 Jan 12;18(1):103. PMID: 41599210
Pharmaceutics

CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein. [Abstract]

2025 Nov 27;17(12):1524. PMID: 41471039
J Ethnopharmacol

Liquiritin prevents preterm labor by remodeling decidual steroid homeostasis through 11β-HSD1 inhibition. [Abstract]

2026 Jun 24:371:122040. PMID: 42341859
Ecotoxicol Environ Saf

Calcitriol alleviates noise-induced hearing loss by regulating the ATF3/DUSP1 signalling pathway. [Abstract]

2024 Oct 1:284:116906. PMID: 39182283
Cell Biosci

The RBM39 degrader indisulam inhibits acute megakaryoblastic leukemia by altering the alternative splicing of ZMYND8. [Abstract]

2025 Apr 13;15(1):46. PMID: 40223119
Mol Ther Nucleic Acids

miR-199a-3p increases the anti-tumor activity of palbociclib in liver cancer models. [Abstract]

2022 Jul 20:29:538-549. PMID: 36035756
Cell Mol Life Sci

Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas. [Abstract]

2021 Feb;78(4):1837-1851. PMID: 32851475
Life Sci

CXCL10 modulates airway inflammation in asthma via Sirt3-dependent macrophage homeostasis. [Abstract]

2025 Oct 15:379:123849. PMID: 40651693
Life Sci

Glucocorticoid reduces mortality in LPS-induced sepsis mouse model by inhibiting JAK1/STAT3-mediated inflammatory response and restoring tricarboxylic acid cycle. [Abstract]

2025 Aug 15:375:123744. PMID: 40408938
RSC Adv

Enhancing solubility and stability of sorafenib through cyclodextrin-based inclusion complexation: in silico and in vitro studies. [Abstract]

2023 Sep 11;13(39):27244-27254. PMID: 37701271
Neurobiol Dis

Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke. [Abstract]

2025 Sep:213:107020. PMID: 40623479
Neurobiol Dis

P2X7-dependent constitutive Interleukin-1β release from pyramidal neurons of the normal mouse hippocampus: Evidence for a role in maintenance of the innate seizure threshold. [Abstract]

2022 Jun 15:168:105689. PMID: 35288304
J Am Heart Assoc

Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. [Abstract]

2021 Jul 20;10(14):e019877. PMID: 34219469
Matrix Biol

Delayed inhibition of collagen deposition by targeting bone morphogenetic protein 1 promotes recovery after spinal cord injury. [Abstract]

2023 Apr:118:69-91. PMID: 36918086
Matrix Biol

Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction. [Abstract]

2022 Sep:112:171-189. PMID: 36031013
Eur J Pharmacol

GW4064 inhibits migration and invasion in human glioblastoma multiforme through the downregulation of PKCα. [Abstract]

2025 Mar 15:991:177329. PMID: 39900326
J Affect Disord

Roflumilast: Modulating neuroinflammation and improving motor function and depressive symptoms in multiple sclerosis. [Abstract]

2024 Apr 1:350:761-773. PMID: 38220100
Int Immunopharmacol

Lactylation of MYH9 and its impact on FOXO3a/Bim signaling in sepsis-induced gut-vascular barrier injury. [Abstract]

2025 Oct 30:164:115384. PMID: 40850198
Int Immunopharmacol

OPTN ameliorates chondrocyte apoptosis in temporomandibular joint osteoarthritis by modulating ER-mitochondria Ca2+ transfer. [Abstract]

2025 Jun 5:157:114796. PMID: 40339496
Int Immunopharmacol

Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma. [Abstract]

2025 Mar 26:150:114278. PMID: 39954659
Mol Neurobiol

Long-Term High-Fat Diet Impairs AQP4-Mediated Glymphatic Clearance of Amyloid Beta. [Abstract]

2025 Jan;62(1):1079-1093. PMID: 38958889
Mucosal Immunol

Obeticholic acid ameliorates severity of Clostridioides difficile infection in high fat diet-induced obese mice. [Abstract]

2021 Mar;14(2):500-510. PMID: 32811993
Inflammation

Inhibition of Cullin3 Neddylation Alleviates Diabetic Retinopathy by Activating Nrf2 Signaling to Combat ROS-Induced Oxidative Stress and Inflammation. [Abstract]

2025 Mar 1. PMID: 40021543
Front Pharmacol

Hsp47 Inhibitor Col003 Attenuates Collagen-Induced Platelet Activation and Cerebral Ischemic-Reperfusion Injury in Rats. [Abstract]

2022 Jan 10;12:792263. PMID: 35082674
Front Pharmacol

15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo. [Abstract]

2018 Jan 30:9:25. PMID: 29441017
J Ovarian Res

BRCA1 and BRCA2 deficient tumour models generate distinct ovarian tumour microenvironments and differential responses to therapy. [Abstract]

2023 Nov 28;16(1):231. PMID: 38017453
ACS Omega

2025 Dec 23.
Molecules

Characterization of Thymoquinone-Sulfobutylether-β-Cyclodextrin Inclusion Complex for Anticancer Applications. [Abstract]

2023 May 15;28(10):4096. PMID: 37241838
Sci Rep

BTK promotes neuroinflammation after intracerebral hemorrhage involving hub genes and alterations in microglial functions. [Abstract]

2026 May 4;16(1):20485. PMID: 42082621
Sci Rep

A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancer. [Abstract]

2026 Apr 20;16(1):12890. PMID: 42009845
Sci Rep

Combinatorial immunotherapy with gemcitabine and ex vivo-expanded NK cells induces anti-tumor effects in pancreatic cancer. [Abstract]

2023 May 11;13(1):7656. PMID: 37169953
Cancer Sci

Xenotransplantation elicits salient tumorigenicity of adult T-cell leukemia-derived cells via aberrant AKT activation. [Abstract]

2016 May;107(5):638-43. PMID: 26928911
Int J Cancer

Impact of bevacizumab in combination with erlotinib on EGFR-mutated non-small cell lung cancer xenograft models with T790M mutation or MET amplification. [Abstract]

2016 Feb 15;138(4):1024-32. PMID: 26370161
Sci Rep

The Akt-mTOR axis is a pivotal regulator of eccentric hypertrophy during volume overload. [Abstract]

2015 Oct 30:5:15881. PMID: 26515499
Neuropharmacology

Assessing the utility of the neurosteroid zuranolone to modify alcohol-related behaviours. [Abstract]

2026 May 1:288:110833. PMID: 41520874
Oncol Rep

Non‑invasive monitoring of cisplatin and erlotinib efficacy against lung cancer in orthotopic SCID mouse models by small animal FDG‑PET/CT and CT. [Abstract]

2019 Jan;41(1):447-454. PMID: 30365151
J Neurochem

Cocaine-Induced Changes in the BRD4 Interactome Identifies Casein Kinase 1 Epsilon as a Therapeutic Target. [Abstract]

2026 Jan;170(1):e70336. PMID: 41521463
Acta Biochim Biophys Sin (Shanghai)

Ciclopirox suppresses melanoma growth by activating ER stress-driven apoptosis and disrupting Src/STAT3 signaling. [Abstract]

2026 Jul 13. PMID: 42441369
iScience

5-HT promotes bronchopulmonary dysplasia via TGM2-mediated serotonylation. [Abstract]

2025 Nov 19;28(12):114120. PMID: 41438086
Neurochem Res

3BDO Alleviates Seizures and Improves Cognitive Function by Regulating Autophagy in Pentylenetetrazol (PTZ)-Kindled Epileptic Mice Model. [Abstract]

2022 Dec;47(12):3777-3791. PMID: 36243819
Lung

Disulfiram Alleviates MTX-Induced Pulmonary Fibrosis by Inhibiting EMT in Type 2 Alveolar Epithelial Cells. [Abstract]

2024 Nov 27;203(1):4. PMID: 39601871
J Biol Chem

Nerve injury augments Cacna2d1 transcription via CK2-mediated phosphorylation of the histone deacetylase HDAC2 in dorsal root ganglia. [Abstract]

2024 Nov;300(11):107848. PMID: 39357831
Mol Immunol

HSP47 inhibitor Col003 attenuates thromboinflammation after cerebral ischemia-reperfusion by suppressing GPVI-mediated CD84 shedding in platelets. [Abstract]

2026 Jul:195:186-197. PMID: 42172863
Mol Immunol

The mechanism underlying ICAM-1 and E-selectin-mediated hypertriglyceridemic pancreatitis-associated lung injury. [Abstract]

2022 Dec:152:55-66. PMID: 36279659
PLoS Negl Trop Dis

CYP51 is an essential drug target for the treatment of primary amoebic meningoencephalitis (PAM). [Abstract]

2017 Dec 28;11(12):e0006104. PMID: 29284029
ChemMedChem

Advancing Accurate Quantification of Protein-Ligand Interactions: Differential Scanning Calorimetry as a Precision Screening Tool Using BCL-2 as a Model System. [Abstract]

2026 Mar 13;21(5):e202500744. PMID: 41774457
BMC Pharmacol Toxicol

Dimethyl fumarate attenuates liver injury in a mouse model of cecal ligation and puncture by modulating inflammatory, angiogenic and pyroptotic pathways. [Abstract]

2025 Jul 17;26(1):134. PMID: 40676712
Cancer Prev Res

Preventive Treatment with a CD73 Small Molecule Inhibitor Enhances Immune Surveillance in K-Ras Mutant Pancreatic Intraepithelial Neoplasia. [Abstract]

2024 Oct 1;17(10):457-470. PMID: 39099209
Comput Biol Chem

Evaluating solubility, stability, and inclusion complexation of oxyresveratrol with various β-cyclodextrin derivatives using advanced computational techniques and experimental validation. [Abstract]

2024 Oct:112:108111. PMID: 38879954
Neuroscience

Glymphatic Dysfunction in Migraine Mice Model. [Abstract]

2023 Sep 15:528:64-74. PMID: 37516436
Cell Immunol

STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer. [Abstract]

2021 Aug:366:104384. PMID: 34182334
Neuropsychiatr Dis Treat

VRT-043198 Ameliorates Surgery-Induced Neurocognitive Disorders by Restoring the NGF and BNDF Expression in Aged Mice. [Abstract]

2022 May 16:18:1027-1037. PMID: 35607505
J Pain Res

Wrist-Ankle Acupuncture Alleviates Paclitaxel-Induced Neuropathic Pain in Mice by Neuronal α7 Nicotinic Acetylcholine Receptor-Dependent Modulation of Spinal Glutamatergic/NMDAR Signaling. [Abstract]

2026 Jun 3:19:604818. PMID: 42267150
Cereb Cortex

P2X7 receptor-mediated depression-like reactions arising in the mouse medial prefrontal cortex. [Abstract]

2023 Jul 5;33(14):8858-8875. PMID: 37183178
PeerJ

Androgen promotes oocyte development by upregulating gap junction intercellular communication activity in granulosa cells in mice. [Abstract]

2026 Apr 30:14:e21194. PMID: 42083638
PLoS One

Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection. [Abstract]

2025 Feb 5;20(2):e0316952. PMID: 39908288
PLoS One

Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model. [Abstract]

2024 Sep 19;19(9):e0310524. PMID: 39298444
PLoS One

Animal efficacy study of a plant extract complex (BEN815) as a potential treatment for COVID-19. [Abstract]

2023 Sep 14;18(9):e0291537. PMID: 37708114
Physiol Behav

Acupuncture waggle needling alleviates spastic movement disorder in post-stroke rats via GLT-1 activation to modulate Glu/GABA-Gln cycle. [Abstract]

2025 Nov 1:301:115059. PMID: 40783057
Clin Exp Pharmacol Physiol

Combination of Tanshinone IIA and Matrine Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Supressing Ferroptosis via Nrf2/HO-1 Pathway Activation. [Abstract]

2025 Nov;52(11):e70072. PMID: 41063422
Biochem Biophys Res Commun

GSK126 alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice. [Abstract]

2018 Jun 18;501(1):9-15. PMID: 29654753
Cancer Chemother Pharmacol

Antitumor activity of alectinib, a selective ALK inhibitor, in an ALK-positive NSCLC cell line harboring G1269A mutation: Efficacy of alectinib against ALK G1269A mutated cells. [Abstract]

2016 Mar;77(3):623-8. PMID: 26849637
Biochem Biophys Res Commun

Chronopharmacodynamics and mechanisms of antitumor effect induced by erlotinib in xenograft-bearing nude mice. [Abstract]

2015 May 1;460(2):362-7. PMID: 25791480
Biopharm Drug Dispos

The possible clinical impact of risperidone on P-glycoprotein-mediated transport of tacrolimus: A case report and in vitro study. [Abstract]

2018 Jan;39(1):30-37. PMID: 29055041
Oncol Lett

Therapeutic effects of paeonol on non‑small cell lung cancer cells via regulation of the MAPK pathway. [Abstract]

2024 Sep 24;28(6):560. PMID: 39372664
Oncol Lett

Ex vivo model of non-small cell lung cancer using mouse lung epithelial cells. [Abstract]

2017 Dec;14(6):6863-6868. PMID: 29344123
Hematology

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2026 Dec 31;31(1):2691533. PMID: 42372253
World Neurosurg

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2022 Feb:158:e856-e864. PMID: 34838764
bioRxiv

2026 Jul 14:2026.07.13.738221. PMID: 42523238
SSRN

2026 Jun 23.
medRxiv

A liver-heart endocrine axis revealed by systems genetics and mediated by hepatocyte growth factor activator. [Abstract]

2026 May 6:2026.05.05.26352474. PMID: 42145616
SSRN

2026 May 21.
bioRxiv

Zuranolone mitigates delirium-like bispectral EEG changes, behavioral deficits, and neuroinflammation across surgical and inflammatory mouse models and age groups. [Abstract]

2026 May 21:2026.05.19.726175. PMID: 42239266
bioRxiv

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2026 Apr 8:2026.04.05.713683. PMID: 41993287
bioRxiv

Circuit-selective cognitive vulnerability to environmental stress: multi-domain assessment of space radiation in both sexes reveals countermeasure trade-offs. [Abstract]

2026 Mar 30:2026.03.26.714605. PMID: 41959325
bioRxiv

2026 Mar 6.
J Mol Liq

2026 Feb 15.
bioRxiv

2025 Oct 6.
bioRxiv

BRD2 Upregulation as a Pan-Cancer Adaptive Resistance Mechanism to BET Inhibition. [Abstract]

2025 Sep 3:2025.08.30.673282. PMID: 40949948
ALA-Porphyrin Science

2025.
bioRxiv

Oncogenic and tumor-suppressive forces converge on a progenitor-orchestrated niche to shape early tumorigenesis. [Abstract]

2025 Jun 12:2025.06.10.656791. PMID: 40661354
Patent

US20250144040A1.
bioRxiv

2025 March 14.
Guidelines and Standards in Chinese Medicine

2024 Dec.
Res Sq

2024 Jul 12.
SSRN

2024 Jun 19.
biorxiv

2024 Jun 05.
bioRxiv

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis. [Abstract]

2024 Jun 28:2024.06.23.600305. PMID: 38979280
bioRxiv

2024 Apr 12.
bioRxiv

RBM39 degrader invigorates natural killer cells to eradicate neuroblastoma despite cancer cell plasticity. [Abstract]

2024 Mar 25:2024.03.21.586157. PMID: 38585889
Res Sq

Dual activity of Minnelide chemosensitize basal/triple negative breast cancer stem cells and reprograms immunosuppressive tumor microenvironment. [Abstract]

2024 Feb 22:rs.3.rs-3959342. PMID: 38464167
bioRxiv

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma. [Abstract]

2023 Oct 1:2023.09.29.560194. PMID: 37808711
bioRxiv

2023 Oct 10.
bioRxiv

CDK6-mediated endothelial cell cycle acceleration drives arteriovenous malformations in hereditary hemorrhagic telangiectasia. [Abstract]

2023 Sep 16:2023.09.15.554413. PMID: 37745444
Research Square Preprint

2023 Sep 18.
University of Ottawa

2023 Jun 12.
Oxid Med Cell Longev

Treatment with the Ferroptosis Inhibitor Ferrostatin-1 Attenuates Noise-Induced Hearing Loss by Suppressing Ferroptosis and Apoptosis. [Abstract]

2022 Dec 7:2022:3373828. PMID: 36531206
Patent

US20220380473A1.
J Mol Liq

9 September 2022, 120314.
Research Square Print

2022 Jun.
Research Square Preprint

2022 May.
Patent

US20220002420A1.
University of Cambridge

2021 , e20.
ETH Zurich

2021 Apr.
Patent

US20200385396A1.
Patent

US20170290918A1.
University of Chile

2017.

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H₂O : ≥ 100 mg/mL

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References

[1]. Fukuda M, et al.Influence of sulfobutyl ether beta-cyclodextrin (Captisol) on the dissolution properties of a poorly soluble drug from extrudates prepared by hot-melt extrusion.Int J Pharm. 2008 Feb 28;350(1-2):188-196 [Content Brief]

[2]. Charman SA, et al. Alteration of the intravenous pharmacokinetics of a synthetic ozonide antimalarial in the presence of a modified cyclodextrin. J Pharm Sci. 2006 Feb;95(2):256-67 [Content Brief]

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SBE-β-CD

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