Cholinesterase (ChE) Inhibitor

Insecticidal agent 21 (Compound 6) is an insecticide that is effective against Culex pipiens larvae (LC₅₀: 0.4 μg/mL). Insecticidal agent 21 achieves multi-target neurotoxicity by inhibiting acetylcholinesterase (AChE) and simultaneously targeting other neural receptors (nicotinic acetylcholine receptors (nAChR), voltage-gated sodium channels (VGSC), and γ-aminobutyric acid receptors (GABAAR)). Insecticidal agent 21 has a strong insecticidal effect and can be used in the development of new insecticides to address the problem of mosquito resistance to traditional insecticides.

Quintiofos (Oxinothiofos) is an insecticide. Quintiofos inhibits the activity of acetylcholinesterase in insects, causing nerve conduction disorders, thereby achieving an insecticidal effect. Quintiofos can be used to control a variety of pests, such as aphids, whiteflies, and stem borers.

Protriptyline (N-methyl-d₃) (hydrochloride) is the deuterium labeled Protriptyline hydrochloride. Protriptyline hydrochloride is a tricyclic antidepressant (TCA), specifically a secondary amine, for the treatment of depression and ADHD. Unique among the TCAs, protriptyline tends to be energizing instead of sedating, used for narcolepsy to achieve a wakefulness-promoting effect.

Arisugacin C is an acetylcholinesterase (AChE) inhibitor with an IC₅₀ of 2.5 μM.

4-Chlorochalcone (Compound 3) is a monoamine oxidase inhibitor (hMAO-B: IC₅₀ = 0.082 μM, hMAO-A: IC₅₀ = 9.95 μM). 4-Chlorochalcone also exhibits inhibitory activity against cholinesterase (AChE: IC₅₀ = 2.79 μM). 4-Chlorochalcone is a chalcone derivative.

AChE-IN-83 (compound f1) is an inhibitor of AChE that inhibits the growth of nematodes and acetylcholinesterase in rice seeds and is safe for rice seeds. AChE-IN-83 targets Aphelenchoides oryzae with an LC50 value of 19.0 μg/mL (48 hr). AChE-IN-83 can inhibit the population and behavior of rice nematodes in rice seeds, destroy the nematode cuticle, and lead to the production of reactive oxygen species, lipofuscin, and lipids in the nematodes.

Acotiamide-d₄ (Z-338 (free base)-d₄) is deuterium labeled Acotiamide. Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC₅₀ of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.

N-Demethyl amiton oxalic is an irreversible cholinesterase (ChE) inhibitor. N-Demethyl amiton oxalic elicits low-level postganglionic neuronal firing in cat vesical parasympathetic ganglia by preventing the breakdown of endogenously released ChE. N-Demethyl amiton oxalic inhibits ChE activity in squid optic ganglia and induces hyperactivity, ink ejection, pigment changes, and death, with a rate of enzymatic detoxification much lower than that of DFP. N-Demethyl amiton oxalic can be used in studies related to the mechanisms of cholinergic transmission in parasympathetic ganglia and neurotoxicology.

Methyl ganoderate A acetonide, a lanostane triterpene, is a natural product that could be isolated from the fruiting bodies of Ganoderma lucidum. Methyl ganoderate A acetonide is a potent AChE inhibitor with an IC₅₀ value of 18.35 μM. Methyl ganoderate A acetonide can be used in research of Alzheimer’s disease (AD).

Galanthaminone (Standard) is the analytical standard of Galanthaminone. This product is intended for research and analytical applications. Galanthaminone (Narwedin) is a competitive and reversible cholinesterase (AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments.

Tacrine (Standard) is the analytical standard of Tacrine. This product is intended for research and analytical applications. Tacrine is an effective oral acetylcholine (AChE) inhibitor (IC50 = 109 nM) and also acts as an active substrate for CYP1A2. Tacrine can restore cognitive dysfunction in elderly rats. Tacrine can cause liver toxicity and is used in research related to Alzheimer's disease.

Ajmalicine (Standard) is the analytical standard of Ajmalicine. This product is intended for research and analytical applications. Ajmalicine (Raubasine) is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine also can be used as anti-hypertensive, and serpentine, with sedative activity.

(S)-Ladostigil (TV-3279), the S-enantiomer of TV 3326 (HY-10399), is a ChE inhibitor with poor MAO-B inhibitory activity. (S)-Ladostigil has neuroprotective effect

Mobam is a insecticide against Anoplura Pediculidae. Mobam inhibits cholinesterase (ChE) levels in rats plasma, erythrocytes, and brain, suppresses the avoidance behavior in rats.

AChE-IN-115 is an acetylcholinesterase (AChE) inhibitor. AChE-IN-115 forms stable complexes with AChE from Spodoptera litura (tobacco cutworm) and Tribolium castaneum (red flour beetle). AChE-IN-115 exhibits insecticidal activity.

Donepezil-d₇ (E2020-d₇ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.

RPR121056 (Standard) is the analytical standard of RPR121056. This product is intended for research and analytical applications. RPR121056 (APC) is a metabolite of Irinotecan (CPT-11), which is generated by CYP3A4. Irinotecan (CPT-11) is an antineoplastic agent that inhibits topoisomerase type I, causing cell death, and is widely used in the treatment of colorectal cancer. Irinotecan also directly inhibits AChE[1].

TAE-1 is a potent inhibitor of AChE and BuChE. TAE-1 also inhibits Aβ fibril formation and aggregation. TAE-1 can be used for the researches of Alzheimer's disease.

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.