N-Demethyl amiton oxalic
N-Demethyl amiton oxalic is an irreversible cholinesterase (ChE) inhibitor. N-Demethyl amiton oxalic elicits low-level postganglionic neuronal firing in cat vesical parasympathetic ganglia by preventing the breakdown of endogenously released ChE. N-Demethyl amiton oxalic inhibits ChE activity in squid optic ganglia and induces hyperactivity, ink ejection, pigment changes, and death, with a rate of enzymatic detoxification much lower than that of DFP. N-Demethyl amiton oxalic can be used in studies related to the mechanisms of cholinergic transmission in parasympathetic ganglia and neurotoxicology.
For research use only. We do not sell to patients.
- CAS No.: 470-94-0
- Formula: C10H22NO7PS
- Molecular Weight:331.32
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Description
In Vivo
N-Demethyl amiton oxalic (compound 217AO) (100-500 μg/kg; intra-arterial injection; single dose) induces low-level postganglionic neuronal discharge in the cat vesical parasympathetic ganglia, an effect that is blocked by Atropine (HY-B1205)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Loligo pealei (either sex, 15-20 cm in length, 50-100 g in weight)[1]
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Dosage:1.0 mg/kg; 2.0 mg/kg; 3.0 mg/kg; 4.0 mg/kg
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Administration:i.o.
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Result:Reduced optic ganglia ChE activity to 30.8% of control levels at 1.0 mg/kg, with 0 of 6 squids dead.
Reduced optic ganglia ChE activity to 12.3% of control levels at 2.0 mg/kg, with 3 of 5 squids dead.
Reduced optic ganglia ChE activity to 8.2% of control levels at 3.0 mg/kg, with 4 of 4 squids dead.
Reduced optic ganglia ChE activity to 4.9% of control levels at 4.0 mg/kg, with 4 of 4 squids dead.
Yielded an approximate LD50 of 1-2 mg/kg.
Caused ≥90% reduction in optic ganglia ChE activity at lethal doses relative to untreated squids.
Chemical Information
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CAS No. 470-94-0
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Molecular Weight 331.32
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Formula C10H22NO7PS
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SMILES
O=C(C(O)=O)O.O=P(OCC)(SCCN(C)C)OCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-Demethyl amiton oxalic Related Classifications
HY-187664 Related Classifications
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