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SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

For research use only. We do not sell to patients.

SZ1676 Chemical Structure

SZ1676 Chemical Structure

CAS No. : 159325-23-2

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Description

SZ1676 is a derivative of SZ1677, which is a neuromuscular blocking agent.

In Vivo

SZ1676 is the 3-acetoxy derivative[1]. The neuromuscular (NM) effects of SZ1676 and SZ1677 are compared in beagle dogs. SZ1677 (ED90=19.2±2.6 μg/kg) is 1.86 times more potent than SZ1676 (ED90=35.8±2.5 μg/kg)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

707.78

Formula

C37H59BrN2O6
CAS No.
SMILES

C[C@@]12[C@](C[C@H]([N+]3(CCCC3)CC=C)[C@@H]2OC(C)=O)([H])[C@@]4([H])[C@]([C@@]5([C@@](C[C@H](OC(C)=O)[C@@H](N6CCC7(OCCO7)CC6)C5)([H])CC4)C)([H])CC1.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Animal Administration
[2]

Dogs[2]
Beagle dogs of about 10 kg body weight, anesthetized with isofurane are intubated and mechanically ventilated with O2, One fore-leg is fixed above the elbow and the wrist and the ulnar nerve is stimulated at the elbow, percutaneously,with supramaximal electrical impulses of 0.2 ms duration at 0.1 or 0.4 Hz.The force of flxion of the paw (P) is quantitated and contiuously recorded, At first the ED50, ED90 and ED95 of the 2 muscle relaxants (MR) are determined.Thirty min after maximal spontaneous recovery of P,the calculated 2×ED90 is injected and the time course ol the NM and circulatory effects are determined.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References
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SZ1676 Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

SZ1676159325-23-2SZ 1676SZ-1676OthersInhibitorinhibitorinhibit

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