Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (300)
Related Products (300)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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Irbesartan-d6-1
0 ImagesCat. No.: HY-B0202S2CAS No.: 2375621-21-7Irbesartan-d6-1 is the deuterium labeled Irbesartan. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
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BW A256C
0 ImagesCat. No.: HY-19022CAS No.: 98410-36-7Palatrigine is a compound with angiotensin-converting enzyme inhibitory and beta-adrenergic receptor blocking properties.
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Angiotensin II (1-4), human
0 ImagesCat. No.: HY-P1792CAS No.: 52580-29-7Angiotensin II (1-4), human is an endogenous peptide produced from AT I by angiotensin-converting-enzyme (ACE). Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney.
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Hippuryl-Phe-Arg-OH
0 ImagesCat. No.: HY-P4552CAS No.: 73167-83-6Hippuryl-Phe-Arg-OH is the active site on the cell surface of Angiotensin I converting enzyme (ACE).
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Angiotensin II type 1 receptor (181-187)
0 ImagesCat. No.: HY-P10597CAS No.: 275359-37-0Angiotensin II type 1 receptor (181-187) is a 9-amino acid sequence of the second extracellular loop of angiotensin II (Ang II) in the renin-angiotensin system. Angiotensin II type 1 receptor (181-187) serves as the localization epitope of angiotensin II receptor autoantibodies (AT1RaAb) and is used to detect and quantify AT1RaAb levels in serum.
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15-Keto-PGA1
0 ImagesCat. No.: HY-137024CAS No.: 61600-67-715-Keto-PGA1 is a metabolite of PGA1 and has significant vasoconstrictive effects. PGA1 is also a vasoconstrictor and is more potent than equivalent doses of prostaglandin F2α (PGF2α) and angiotensin II.
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Saprisartan potassium
0 ImagesCat. No.: HY-A0229ACAS No.: 146613-90-3Synonyms: GR 138950 potassiumSaprisartan (GR 138950) potassium is a selective, long-acting AT1 receptor antagonist.
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Buloxibutid hydrochloride
0 ImagesCat. No.: HY-100113ACAS No.: 1947313-60-1Synonyms: AT2 receptor agonist C21 hydrochlorideBuloxibutid (AT2 receptor agonist C21) hydrochloride is an orally active, selective angiotensin II type 2 receptor (AT2R) agonist, with a Ki value of 0.4 nM for porcine AT2R. Buloxibutid hydrochloride exerts vasodilatory, anti-inflammatory, antifibrotic (promoting the expression of collagenase MMP-13) and tissue repair effects mainly by activating the NO/cGMP pathway, inhibiting the pro-proliferative MAPK signaling, and suppressing the pro-fibrotic TGF-β/Smad pathway and inflammatory NF-κB pathway. Buloxibutid hydrochloride can be used in research related to idiopathic pulmonary fibrosis, hypertension, systemic sclerosis and other conditions.
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A-779 TFA
0 ImagesCat. No.: HY-P0216AA-779 TFA is a selective angiotensin-(1-7) (Ang-(1-7)) antagonist. A-779 TFA blocks Arachidonic acid release, bradykinin potentiation effects and hypotensive action. A-779 TFA exerts diuretic effects in non-pregnant rats, antidiuretic effects in late-pregnant rats, and also inhibits feed intake and water consumption in late-pregnant rats. A-779 TFA attenuates the regulatory effects of prostacyclin, nitric oxide and thromboxane A2 associated with angiotensin-(1-7). A-779 TFA can be used in studies related to hypertension.
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Antihypertensive agent 2
0 ImagesCat. No.: HY-155041CAS No.: 3049677-56-4
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Olmesartan medoxomil-d6
0 ImagesCat. No.: HY-17005SCAS No.: 1127298-67-2Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM.
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Imarikiren
0 ImagesCat. No.: HY-109034CAS No.: 1202265-63-1Synonyms: AK-272 free base; SCO-272 free baseImarikiren (AK-272 free base) is an orally active, selective Renin inhibitor with an IC50 value of 2.1 nM against h-Renin. Imarikiren blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren can be used in research related to hypertension and heart failure.
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AT1R antagonist 2
0 ImagesCat. No.: HY-146436CAS No.: 2848719-76-4AT1R antagonist 2 (compound 6) is a potent AT1R selective ligand. AT1R antagonist 2 exhibits a fair AT1R affinity, with a Ki of 26 nM.
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LY303336
0 ImagesCat. No.: HY-117447CAS No.: 157187-00-3LY303336 is an antagonist of polysubstituted 4-aminoimidazole AT1 receptor with an IC50 value of 5.2 nM.
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Irbesartan (Standard)
0 ImagesSynonyms: SR-47436 (Standard); BMS-186295 (Standard)Irbesartan (Standard) is the analytical standard of Irbesartan. This product is intended for research and analytical applications. Irbesartan (SR-47436) is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease.
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Forasartan
0 ImagesCat. No.: HY-A0224CAS No.: 145216-43-9Synonyms: SC-52458Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II.
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L-162537
0 ImagesCat. No.: HY-108120CAS No.: 167027-99-8L-162537 is a competitive human angiotensin II receptor 1 (AT1) and receptor 2 (AT2) antagonist with an IC50=1.7 nM for AT1. L-162537 inhibits Ang II-mediated vasoconstriction, blood pressure elevation and related pathological signaling pathways. L-162537 is promising for research of angiotensin II-related cardiovascular diseases such as hypertension.
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Losartan carboxylic acid-d4 hydrochloride
0 ImagesCat. No.: HY-12765S1Losartan carboxylic acid-d4 (hydrochloride) is deuterium labeled Losartan Carboxylic Acid. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.
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ICI-D 8731
0 ImagesCat. No.: HY-19155ACAS No.: 135015-84-8Synonyms: ZD-8731ICI-D 8731 (compound 5g) is a angiotensin II receptor antagonist with the IC50 of 0.031 μM. ICI-D 8731 shows a rapid and sustained lowering of blood pressure in a renal hypertensive rat model.
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Angiotensin I/BSA
0 ImagesCat. No.: HY-161529Angiotensin I/BSA is an antigen-adjuvant conjugate of Angiotensin I and bovine serum albumin (BSA). By conjugating the antigen with a protein adjuvant, the production of antigen-specific antibodies in vaccine models can be enhanced. The conjugate does not affect protein folding or disrupt major epitopes, and it can enhance cross-presentation and the generation of antigen-specific T cells.
