Angiotensin Receptor
Angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands. They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II. The AT1 and AT2 receptors have a similar affinity for angiotensin II, which is their main ligand. The AT1 receptor is the best elucidated angiotensin receptor. AT2 receptors are more plentiful in the fetus and neonate. Other poorly characterized subtypes include the AT3 and AT4 receptors.
Angiotensin Receptor Isoform Specific Products
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Angiotensin Receptor Inhibitors
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Angiotensin Receptor Agonists
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Angiotensin Receptor Antagonists
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Angiotensin Receptor Activators
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Angiotensin Receptor Modulators
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Angiotensin Receptor Chemicals
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Angiotensin Receptor Ligands
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Angiotensin Receptor Related Products (300)
Related Products (300)
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Antibodies (7)
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Angiotensin Receptor Isoform Comparison
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(Rac)-Valsartan-d9
0 ImagesCat. No.: HY-18204S3Synonyms: (Rac)-CGP 48933-d9(Rac)-Valsartan-d9 is deuterium labeled Valsartan. Valsartan (CGP 48933) is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research.
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EMD-66684 potassium salt
0 ImagesCat. No.: HY-103247BCAS No.: 187683-79-0EMD-66684 potassium salt is a non-peptide angiotensin II receptor antagonist that demonstrates significant antihypertensive effects in spontaneously hypertensive rats. EMD-66684 potassium salt exhibits nanomolar affinity for angiotensin II receptors, comparable to losartan in potency. EMD-66684 potassium salt shows increased activity when modified with acetamides, leading to superior blood pressure reduction.
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Telmisartan (Standard)
0 ImagesSynonyms: BIBR 277 (Standard)Telmisartan (Standard) is the analytical standard of Telmisartan. This product is intended for research and analytical applications. Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.
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Mitolactol
0 ImagesCat. No.: HY-114536CAS No.: 10318-26-0Synonyms: NSC 104800Mitolactol (NSC 104800) is an angiotensin converting enzyme (ACE) inhibitor with the activity of inhibiting ACE (IC50 of 1.4×10 M) and inhibiting the pressor response of angiotensin I when administered intravenously at 0.3 mg/kg in rats.
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Cytosporin A
0 ImagesCat. No.: HY-N14205CAS No.: 175521-93-4Cytosporin A is a hexahydrobenzopyran derivative and an angiotensin II receptor antagonist. Cytosporin A has IC50 values of 25-30 μM and 1.5-3 μM for AT1 and AT2, respectively.
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Zilebesiran sodium scrambled negative control
0 ImagesCat. No.: HY-145649BZilebesiran sodium scrambled negative control is the sequence scrambled negative control of Zilebesiran sodium.
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Chymase
0 ImagesCat. No.: HY-131162CAS No.: 97501-92-3Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies.
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5-Valine-angiotensin I
0 Images5-Valine-angiotensin I is an Ang I peptide belonging to angiotensin I. 5-Valine-angiotensin I induces muscle contraction, can be used for renin-angiotensin system studies. Angiotensin I is a putative neurotransmitter, is the precursor of angiotensin II and of angiotensin fragment 1-7, which are involved in regulation of fluid volume and the release of aldosterone.
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AT1R antagonist 1
0 ImagesCat. No.: HY-146431CAS No.: 2848719-80-0AT1R antagonist 1 (compound 10) is a potent AT1R selective ligand. AT1R antagonist 1 exhibits a fair AT1R affinity, with a Ki of 8.5 nM.
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(+)-Chloroquine
0 ImagesCat. No.: HY-156862CAS No.: 58175-86-3(+)-Chloroquine is a aminoquinoline drug impairs in vitro the terminal glycosylation of angiotensin-converting enzyme 2 (ACE-2).
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L-162782
0 ImagesCat. No.: HY-125094CAS No.: 169281-92-9L-162782 is a high affinity AT1 receptor ligand for rat and human wild-type AT1 with IC50 values of 28.5 and 24.6 nM, respectively. L-162782 acts as a partial agonist (EC50 ≈ 30 nM) and insurmountable antagonist (IC50 = 6.5 μM) on wild-type rat AT1 receptors in COS-7 cells. L-162782 reduces Angiotensin II (HY-13948)-induced phosphatidylinositol turnover. L-162782 can be used for hypertension research.
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Nva-VYIHPF
0 ImagesCat. No.: HY-P10766CAS No.: 51988-72-8Nva-VYIHPF is an analog of Angiotensin II (HY-13948).
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Milfasartan
0 ImagesCat. No.: HY-101542CAS No.: 148564-47-0Synonyms: LR-B/081Milfasartan (LR-B/081) is a selective angiotensin receptor AT1 antagonist with antihypertensive activity.
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LVV-hemorphin-7
0 ImagesCat. No.: HY-P11643CAS No.: 75808-66-1LVV-hemorphin-7 is an Angiotensin IV receptor ligand and IRAP inhibitor (IC50s: 17.6 nM for sheep adrenal IRAP; 5.0 nM for sheep cerebellum IRAP). LVV-hemorphin-7 inhibits the catalytic activity of IRAP. LVV-hemorphin-7 stimulates DNA synthesis. LVV-hemorphin-7 elicits a number of physiological effects, including cellular proliferation and memory enhancement.
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Norleual
0 ImagesCat. No.: HY-P1415CAS No.: 334994-34-2Norleual, an angiotensin (Ang) IV analog, is a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. Norleual is an AT4 receptor antagonist and exhibits potent antiangiogenic activities.
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Saralasin acetate hydrate
0 ImagesCat. No.: HY-P0205ACAS No.: 39698-78-7Synonyms: [Sar1,Ala8] Angiotensin II acetate hydrateSaralasin ([Sar1,Ala8] Angiotensin II) acetate hydrate is an octapeptide analog of angiotensin II. Saralasin acetate hydrate is a competitive angiotensin II receptor antagonist with a Ki value of 0.32 nM for 74% of the binding sites, and has partial agonist activity as well. Saralasin acetate hydrate can be used for the research of renovascular hypertension, renin-dependent (angiotensinogenic) hypertension.
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[Tyr(P)4] Angiotensin II
![[Tyr(P)4] Angiotensin II](https://file.medchemexpress.com/product_pic/hy-p2563.gif "Click to View [Tyr(P)4] Angiotensin II Product Detail")
0 ImagesCat. No.: HY-P2563CAS No.: 129785-85-9[Tyr(P)4] Angiotensin II is a peptide that has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels.
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Fonsartan free acid
0 ImagesCat. No.: HY-119379CAS No.: 144628-52-4Synonyms: HOE-720 free acidFonsartan (HOE-720) free acid is an orally active angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, exhibiting potent antihypertensive activity. Fonsartan free acid dose-dependently inhibits angiotensin II-induced pressor response in rats (ID50 = 0.11 mg/kg) and shows significant long-lasting blood pressure-lowering effects in high-renin animal models. Fonsartan free acid is primarily used in research on hypertension and cardiovascular diseases.
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AT1R-agonist-1
0 ImagesCat. No.: HY-P11847CAS No.: 3124030-35-6AT1R-agonist-1 is an angiotensin II type 1 receptor (AT1R) agonist with a Ki value of 1.4 nM. AT1R-agonist-1 exhibits low Gαq activity, retains β-arrestin recruitment function, and accesses the deep allosteric pocket inside AT1R via its flexible side chain. AT1R-agonist-1 possesses positive inotropic effects (enhancing cardiac contractile function) and causes almost no increase in blood pressure. AT1R-agonist-1 can be used for research on conditions such as refractory cardiogenic shock.
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Angiotensin I/II (1-5)
0 ImagesCat. No.: HY-P1839CAS No.: 58442-64-1Angiotensin I/II 1-5 is a peptide that contains the amino acids 1-5, which is converted from Angiotensin I/II. Angiotensin I is formed by the action of renin on angiotensinogen. Angiotensin II is produced from angiotensin I. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy.
