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CDK Related Products (482)
Related Products (482)
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Cdk2/Cyclin Inhibitory Peptide I
0 ImagesCat. No.: HY-P3730CAS No.: 237392-84-6Cdk2/Cyclin Inhibitory Peptide I (Tat-LFG), a CDK2 inhibitor, kills U2OS osteosarcoma cells in a dose-dependent manner.
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BNNC
0 ImagesCat. No.: HY-184452BNNC is a Photomolecular glue. BNNC selectively releases (R)-CR8 (HY-18340) (a Cyclin K molecular glue) and BSS-Et in hypoxic tumor microenvironments, thereby triggering Cyclin K degradation dependent on the ubiquitin-proteasome pathway. BNNC generates ROS and singlet oxygen in hypoxic tumor cells under light irradiation. BNNC enhances DNA damage and Apoptosis through the combined effects of Cyclin K degradation and phototherapy. BNNC enhances the tumor selectivity of molecular glue via specific activation in hypoxic tumor microenvironments. BNNC can be used in breast cancer-related research.
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PIN1-IN-7
0 ImagesCat. No.: HY-184932PIN1-IN-8 is a covalent inhibitor of Pin1, with IC50 values of 4.19 μM and 1.54 μM against purified Pin1 and Pin1 enzymatic activity, respectively. PIN1-IN-7 exerts antiproliferative effects and induces apoptosis by downregulating c-Myc and Cyclin D1. PIN1-IN-7 can be used in the research of triple-negative breast cancer.
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ODN BW001 sodium
0 ImagesCat. No.: HY-150213AODN BW001 sodium is an oligodeoxynucleotide (ODN). ODN BW001 sodium plays a regulatory role in the proliferation and activation of osteoblast.
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CDK-IN-19
0 ImagesCat. No.: HY-17679CAS No.: 672324-11-7
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CDK12 R722C/CycK Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70658CDK12 R722C/CycK Recombinant Human Active Protein Kinase is a cyclin-dependent kinase and regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability.
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p38α-IN-9
0 ImagesCat. No.: HY-172807CAS No.: 2133007-20-0p38α-IN-9 (Compound 2015) is a p38α inhibitor and blocks p38α’s enzymatic activity with an IC50 lower than 20 nM. p38α-IN-9 inhibits MK2T334 phosphorylation. p38α-IN-9 activates Cdc25b and Cdc25c and simultaneously inactivates Wee1, leading to mitotic catastrophe, aneuploidy or polyploidy and DNA damage. p38α-IN-9 Inhibits colorectal cancer (CRC) metastasis.
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SNX2-1-108
0 ImagesCat. No.: HY-117988CAS No.: 1366002-73-4SNX2-1-108 is a CDK8 kinase inhibitor.
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CDK20/CycT1 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70676CDK20 is a major controller of cell cycle checkpoints, which regulate cell growth and proliferation and perform a role in the development of many malignancies. CDK20 is thought to have Cyclin-dependent activating kinase (CAK) activity for CDK2 when it is complexed with Cyclin H. CDK20/CycT1 Recombinant Human Active Protein Kinase is an ortholog of CDK20.
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CLK2/3-IN-1
0 ImagesCat. No.: HY-173510CLK2/3-IN-1 (Compound 7c) is an orally active CLK2/3 inhibitor (EC50: 5.07 nM and 30.03 nM, respectively). CLK2/3-IN-1 binds to Lys193 and Lys186 of CLK2/3 via hydrogen bonds. CLK2/3-IN-1 can inhibit the proliferation of SW480 tumor cells (IC50: 163 nM). CLK2/3-IN-1 can be used to study CLK-related tumor diseases.
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CDK1/CycE1 Recombinant Human Active Protein Kinase
0 ImagesCat. No.: HY-E70654CDK1 is a cyclin-dependent kinase that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. CDK1/CycA1 Recombinant Human Active Protein Kinase is an ortholog of CDK1.
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CDK4/6-IN-22
0 ImagesCat. No.: HY-161978CAS No.: 3036014-62-4
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Telapristone acetate
0 ImagesCat. No.: HY-16483CAS No.: 198414-31-2Synonyms: CDB-4124Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research.
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Aloisine B
0 ImagesCat. No.: HY-118902CAS No.: 496864-14-3Aloisine B (compound 9) is a cyclin-dependent kinase (CDK) inhibitor. Aloisine B inhibits cell proliferation by arresting cells in both G1 and G2 via competing with ATP-binding pocket.
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Garcinone C (Standard)
0 ImagesCat. No.: HY-N6954RCAS No.: 76996-27-5Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active.
