198414-31-2
Chemical Structure
Telapristone acetate
Synonym(s): CDB-4124
- CAS No.: 198414-31-2
- Formula:C31H39NO5
- Molecular Weight:505.65
IUPAC Name: (8S,11R,13S,14S,17R)-11-(4-(dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
InChIKey: JVBGZFRPTRKSBB-MJBQOYBXSA-N
SMILES: C[C@@]12[C@](CC[C@]2(OC(C)=O)C(COC)=O)([H])[C@@]3([H])C([C@@H](C4=CC=C(N(C)C)C=C4)C1)=C(CC5)C(CC3)=CC5=O
Biological Activity: Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research[1][2].
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Telapristone acetate | Telapristone acetate (CDB-4124) is a potent progesterone receptor (PR) modulator. Telapristone acetate inhibits the proliferation of ovarian cancer cells by inducing cell cycle arrest and apoptosis. Telapristone effectively inhibits the occurrence and development of spontaneous and chemically induced mammary tumors in rats. Telapristone acetate can be used for breast and ovarian cancer research. | |||||||||||||||||||||
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- [1]. Carlos D Gamarra-Luques,et al. Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin-induced cytotoxicity. J Ovarian Res. 2014 Apr 27;7:45. [Content Brief]
- [2]. Wiehle R, et al. CDB-4124, a progesterone receptor modulator, inhibits mammary carcinogenesis by suppressing cell proliferation and inducing apoptosis. Cancer Prev Res (Phila). 2011 Mar;4(3):414-24. [Content Brief]
Keywords
