2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. CDK
  5. CDK Isoform
  6. CDK Antagonist

CDK Antagonist

CDK Antagonist (1):

Cat. No. Product Name Effect Purity
  • HY-108136
    Bisindolylmaleimide X
    		Antagonist
    Bisindolylmaleimide X (Ro 31-8425, BIM-X) is a cell-penetrating PKC inhibitor. Bisindolylmaleimide X is a potent cyclin-dependent kinase 2 (CDK2) antagonist with an IC50 of 200 nM. Bisindolylmaleimide X inhibits the proliferation of CD4 T cells in vitro. Bisindolylmaleimide X inhibits eNOS-Ser1177 phosphorylation in human embryonic vein endothelial cells. Bisindolylmaleimide X can be used for research on the immune system and cardiovascular diseases.