BNNC

BNNC (300 μg/mL RLM, 100 μM NADH; 40 min) exhibits stable and robust phototherapeutic functions and stability; after incubation with 300 μg/mL RLM for 40 min, it can fully respond to hypoxic environments to release (R)-CR8 and BSS-Et^[1].
BNNC (30 μM; 1.5 h) generates reactive oxygen species in hypoxic 4T1 cells after 5 min of irradiation with an 808 nm laser at a power density of 1.5 W·cm^−2[1].
BNNC (30 μM; 2 h) selectively induces ubiquitin-proteasome-dependent Cyclin K degradation in hypoxic 4T1 cells, but exerts no such effect in normoxic 4T1 cells^[1].
BNNC (0-30 μM; 24 h) exhibits enhanced synergistic cytotoxicity against hypoxic 4T1 cells under 808 nm laser irradiation, reducing cell viability to less than 20% at a concentration of 30 μM, whereas it shows low cytotoxicity toward L02 hepatocytes at the same concentration^[1].
BNNC (0-30 μM) induces extensive 4T1 cell death under hypoxic conditions combined with 808 nm laser irradiation, and the proportion of dead cells is much higher than that of either single treatment^[1].
BNNC (30 μM; 2 h) significantly increases the level of activated Caspase-3 in hypoxic 4T1 cells upon irradiation with an 808 nm laser^[1].
BNNC (10-100 μM; 3 h) exhibits excellent hemocompatibility in mouse red blood cells, with a hemolysis rate of less than 5% even at a concentration of 100 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.