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  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Nombre del producto Efecto Pureza Chemical Structure
  • HY-135438
    Mollugogenol A
    		Inhibitor
    Mollugogenol A is a fungal inhibitor. Mollugogenol A can cause damage to sperm membranes by increasing lipid peroxidation, exhibiting sperm-killing activity.
    Mollugogenol A
  • HY-179296
    SDH-IN-41
    		Inhibitor
    SDH-IN-41 (Compound 3d-1) is an antifungal agent, SDH inhibitor, with an IC50 value of 4.14 mg/L against SsSDH. SDH-IN-41 shows antifungal activity against S. sclerotiorum with an EC50 value of 1.86 mg/L.
    SDH-IN-41
  • HY-N14324
    Hydranthomycin
    		Inhibitor
    Hydranthomycin is an antibiotic. Hydranthomycin has moderate antifungal activity, and the MIC of Pyricularia oryzae is 25 μg/mL. Hydranthomycin inhibits the growth of Euglena gracilis and has herbicidal activity.
    Hydranthomycin
  • HY-136764
    CYP51-IN-14
    		Inhibitor
    CYP51-IN-2 (compound 1n), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 1 μg/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-14
  • HY-N1448R
    Vincetoxicoside B (Standard)
    		Inhibitor
    Vincetoxicoside B (Standard) is the analytical standard of Vincetoxicoside B. This product is intended for research and analytical applications. Vincetoxicoside B shows antifungal activity.
    Vincetoxicoside B (Standard)
  • HY-169987
    bc1 Complex-IN-1
    		Inhibitor
    bc1 Complex-IN-1 (compound 12g) is a potent bc1 complex inhibitor. bc1 Complex-IN-1 shows fungicidal properties against Cucumber downy mildew (CDM).
    bc1 Complex-IN-1
  • HY-B0537A
    Pentamidine dihydrochloride
    		Inhibitor
    Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dihydrochloride is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dihydrochloride has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine dihydrochloride
  • HY-W715812
    Bromuconazole
    		Inhibitor
    Bromuconazole is a triazole fungicide with oral efficacy and blood-brain barrier permeability. Bromuconazole protects crops from various fungal contaminations. Bromuconazole exhibits cytotoxicity against a variety of cancer cells, induces G0/G1 cell cycle arrest and inhibits DNA synthesis in cancer cells, and triggers cytoskeletal structural disorder, genotoxic damage, apoptotic (apoptosis) cell death, and mitochondrial membrane depolarization. Bromuconazole activates caspase-3, induces excessive production of ROS, p53 and Bax, lipid peroxidation, increased activities of SOD and CAT, and downregulates Bcl-2. By upregulating p-ERK1/2 and p-JNK, Bromuconazole disrupts the MAPK signaling pathway, impairs the cellular stress response of human trophoblast cells and endometrial cells, and damages the implantation process. Bromuconazole is applicable to research related to glioma, colon cancer, reproductive injury (implantation dysfunction), and cardiac dysfunction.
    Bromuconazole
  • HY-W021008S
    Sotolone-d2
    		Inhibitor
    Sotolone-d2 (Dimethylhydroxyfuranone-d2) is deuterated labeled Sotolone. Sotolone is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC50 values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro.
    Sotolone-d<sub>2</sub>
  • HY-N4283R
    Coniferyl alcohol (Standard)
    		Inhibitor
    Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation.
    Coniferyl alcohol (Standard)
  • HY-N5185
    Cyclothiazomycin
    		Inhibitor
    Cyclothiazomycin selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. Cyclothiazomycin has weak antifungal activity.
    Cyclothiazomycin
  • HY-136760
    CYP51-IN-10
    		Inhibitor
    CYP51-IN-10 is cytochrome P450 14a-demethylase (CYP51) inhibitor with antifungal activity. CYP51-IN-10 can be used for the research of fungal infection.
    CYP51-IN-10
  • HY-N14669
    Cladospolide D
    		Inhibitor
    Cladospolide D is found in the strain of Cladosporium sp. FT-0012. Cladospolide D has the activity against part of fungi.
    Cladospolide D
  • HY-N15184
    Benanomicin B
    		Inhibitor
    Benanomicin B (Pradimicin C) is an antifungal antibiotic that also has antibacterial activity against two Gram-positive bacteria: Micrococcus luteus and Corynebacterium bovis.
    Benanomicin B
  • HY-175722
    JSZ16
    		Inhibitor
    JSZ16 is a Succinate dehydrogenase (SDH) inhibitor with an IC50 of 30.3  μM. JSZ16 has potent broad-spectrum fungicidal activity, such as Sclerotinia sclerotiorum, Botrytis cinerea and Colletotrichum fragariae, with an EC50 of 4.4 mg/L for Sclerotinia sclerotiorum. JSZ16 influences the cell membrane permeability of pathogenic fungi. JSZ16 can be used for the development of fungicide.
    JSZ16
  • HY-W701251
    Ethylparaben-d5
    		Inhibitor
    Ethylparaben-d5 (Ethyl parahydroxybenzoate-d5) is deuterium labeled Ethylparaben. Ethylparaben is the ethyl ester of paraben and is used as an antifungal preservative and food additive.
    Ethylparaben-d<sub>5</sub>
  • HY-N13997
    Clavamycin C
    		Inhibitor
    Clavamycin C has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin C
  • HY-16246R
    Haloprogin (Standard)
    		Inhibitor
    Haloprogin (Standard) is the analytical standard of Haloprogin. This product is intended for research and analytical applications. Haloprogin is a potent antifungal agent. Haloprogin has activity against dermatophytes, Candida spp and a limited number of Gram-positive bacteria.
    Haloprogin (Standard)
  • HY-179493
    DHFR-IN-25
    		Inhibitor
    DHFR-IN-25 (Compound N2) is a type of inhibitor of dihydrofolate reductase (DHFR). DHFR-IN-25 is a broad-spectrum and highly effective antibacterial agent, particularly showing significant effects on Candida albicans and Staphylococcus aureus. DHFR-IN-25 can be used for the study of local anti-infection.
    DHFR-IN-25
  • HY-108004R
    Decamethoxine (Standard)
    		Inhibitor
    Decamethoxine (Standard) is the analytical standard of Decamethoxine (HY-108004). This product is intended for research and analytical applications. Decamethoxine (Septefril) is a cationic gemini surfactant. Decamethoxine exhibits strong bactericidal and fungicidal effects. Decamethoxine modifies the permeability of the microbial cell membrane, resulting in the destruction and death of diverse microorganisms.
    Decamethoxine (Standard)
Cat. No. Nombre del producto / Synonyms Application Reactivity