Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
-
Fungal Related Products (2733)
Related Products (2733)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Becliconazole
0 ImagesCat. No.: HY-W714655CAS No.: 112893-26-2
-
CYP51-IN-27
0 ImagesCat. No.: HY-178162CYP51-IN-27 is a sterol 14α-demethylase CYP51 inhibitor with an IC50 of 0.3434 μg/mL. CYP51-IN-27 exhibits antifungal activity and inhibits the production of fungal ergosterol. CYP51-IN-27 can be used for the research of infection, such as rice sheath blight.
-
Cranberry Extract
0 ImagesCat. No.: HY-N13200Cranberry Extract is the extract of Cranberry, with content of 25% -50% Proanthocyanidins. Cranberry Extract exhibits anti-virus and antimicrbiol activity. Cranberry Extract suppresses fungal growth and biofilm formation. Cranberry Extract reduces NF-κB p65 phosphorylation, and PI3K/AKT signaling; increases caspase-8/9 activity to induce apoptosis, modulates oxidative stress, inflammation, and lipid profiles. Cranberry Extract exerts antiproliferative effects and induces cell cycle arrest. Cranberry Extract can be used for the research of infection and cancers.
-
Pradimicin L
0 ImagesCat. No.: HY-169856CAS No.: 142062-87-1Pradimicin L is a homologue of pradimicin A (HY-132191) that can be isolated from the new type of Streptomyces madurensis, and it has antifungal activity.
-
Tetraconazole (Standard)
0 ImagesCat. No.: HY-117089RCAS No.: 112281-77-3Tetraconazole (Standard) is the analytical standard of Tetraconazole. This product is intended for research and analytical applications. Tetraconazole, a chiral triazole fungicide, is widely used for the prevention of plant disease in wheat fields. Tetraconazole alters the methionine and ergosterol biosynthesis pathways in Saccharomyces yeasts promoting changes on volatile derived compounds.
-
Bagremycin A
0 ImagesCat. No.: HY-N13962CAS No.: 377775-45-6Bagremycin A is found in the strain of Streptomyce sp. Tu 4128. Bagremycin A has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
-
2,4,6-Tribromophenyl caproate (Standard)
0 ImagesCat. No.: HY-101506RCAS No.: 16732-09-52,4,6-Tribromophenyl caproate (Standard) is the analytical standard of 2,4,6-Tribromophenyl caproate (HY-101506). This product is intended for research and analytical applications. 2,4,6-Tribromophenyl caproate (2,4,6-tribromophenyl caproic acid ester) is an anti-fungal agent.
-
Bethoxazin
0 ImagesBethoxazin is a yeast DNA topoisomerase II inhibitor with an IC50 of 5.3 μM, and also a broad-spectrum industrial microbicide and covalent adduct-forming agent. Bethoxazin inhibits the catalytic activity of yeast DNA topoisomerase II by reacting with the key free cysteine thiol group on the enzyme. Bethoxazin forms covalent adducts with molecules containing free thiol groups. Bethoxazin inhibits the growth of yeast cells. Bethoxazin can be used in studies related to the growth of fungi, molds and algae.
-
Ravuconazole (Standard)
0 ImagesSynonyms: BMS-207147 (Standard); ER-30346 (Standard)Ravuconazole (Standard) is the analytical standard of Ravuconazole. This product is intended for research and analytical applications. Ravuconazole (BMS-207147;ER-30346) is an orally available triazole antifungle agent that potently inhibits a wide range of fungi.
-
Haliangicin C
0 ImagesCat. No.: HY-N14443CAS No.: 661466-87-1Haliangicin C has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
-
Ramulosin
0 ImagesCat. No.: HY-N14585CAS No.: 29914-01-0Ramulosin has an antifungal effect and inhibits the germination of fungal meristems.
-
DT-23
0 ImagesCat. No.: HY-173452DT-23 is a potent antifungal agent with an MIC50 of 15 μg/mL. DT-23 inhibits recombinant Arg1 and Kcs1 with IC50s of 0.6 and 0.68 μM, respectively.
-
Frenolicin
0 ImagesCat. No.: HY-N14995CAS No.: 10023-07-1Frenolicin is an antibiotic with antibacterial activity. Frenolicin also exhibits cytotoxicity against tumor cells.
-
Hypnophilin
0 ImagesCat. No.: HY-N15082CAS No.: 80677-96-9Hypnophilin has a variety of activities, including anti-Gram-positive bacteria, negative bacteria, yeast, mold and tumor activities.
-
Mycobacillin
0 ImagesCat. No.: HY-N14799CAS No.: 18524-67-9Mycobacillin is a peptide antibiotic with anti-antifungal activity.
-
Alexidine dihydrochloride (Standard)
0 ImagesAlexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens.
-
Alliacol B
0 ImagesCat. No.: HY-N13906CAS No.: 79232-33-0Alliacol B is an antibiotic shows weak antibacterial and antifungal activity. Alliacol B inhibits DNA synthesis in cells of the ascitic form of Ehrlich carcinoma.
-
Asulam potassium
0 ImagesCat. No.: HY-B1838ACAS No.: 14089-43-1Asulam (potassium salt) is a chitin synthase inhibitor against plant pathogenic fungi. Asulam (potassium salt) interferes with the biosynthesis of chitin in the fungal cell wall to destroy the integrity and normal growth and reproduction of fungal cells, thereby exerting bacteriostatic activity. Asulam (potassium salt) is promising for research of fungal diseases such as downy mildew and gray mold in spinach, tulips, daffodils and lilies.
-
PPm
0 ImagesCat. No.: HY-157218CAS No.: 2101951-47-5PPm, a derivative of penthiopyrad and hapten, is a representative member of the succinate dehydrogenase inhibitors group of fungicides.
-
Candicidin D
0 ImagesCat. No.: HY-125152CAS No.: 39372-30-0Synonyms: CndDCandicidin D (CndD) is an antibiotic, which exhibits antifungal activity through interaction with steroids in cell membranes. Candicidin D inhibits S. cerevisiae, Candida albicans and other Candida spp. with MIC of 0.25-1 μg/mL in RPMI-1640 medium.
