1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W020777R
    Triflumizole (Standard)
    Inhibitor
    Triflumizole (Standard) is the analytical standard of Triflumizole. This product is intended for research and analytical applications. Triflumizole is one of imidazole fungicides that works by inhibiting ergosterol biosynthesis, and is widely used for the control of powdery mildew and scabs on various fruits and crops.
    Triflumizole (Standard)
  • HY-N13995
    Serratamolide
    Inhibitor
    Serratamolide is a depsipeptide antibiotic. Serratamolide has anti-Gram-positive bacteria, mycobacteria and fungi activity, but the activity is weak.
    Serratamolide
  • HY-W089091
    Cispentacin
    Inhibitor
    Cispentacin has anti-candida and other fungi activity, and has no toxicity at 1g/kg.
    Cispentacin
  • HY-129548A
    Prumycin dihydrochloride
    Inhibitor
    Prumycin dihydrochloride is an antifungal antibiotic with activity against cucumber powdery mildew. Prumycin dihydrochloride significantly inhibited the disease, whereas other metabolites such as bacillomycin D and surfactin did not. Prumycin dihydrochloride did not induce the expression of plant defense genes, indicating that its effects were not through plant defense responses. Observation of cucumber cotyledons treated with prumycin showed that it could inhibit spore germination of P. fusca.
    Prumycin dihydrochloride
  • HY-159666
    Nystatin A1
    Inhibitor
    Nystatin A1 is a polyene macrolide antifungal antibiotic that can be isolated from Streptomyces noursei. Nystatin A1 binds to ergosterol on the fungal cell membrane, increasing the permeability of the cell membrane and causing leakage of cell contents, thereby inhibiting the growth and reproduction of fungi.
    Nystatin A1
  • HY-N12913
    Antibiotic WB
    Inhibitor
    Antibiotic WB is an antibioticwith antifungal activity and can be isolated from the soil fungus strain 38.
    Antibiotic WB
  • HY-180144
    Antifungal agent 142
    Inhibitor
    Antifungal agent 142 (Compound B1) is a broad-spectrum antifungal agent. Antifungal agent 142 can enhance cell membrane permeability and disrupt membrane integrity, hindering normal mycelial growth. Antifungal agent 142 can be used as agricultural fungicide.
    Antifungal agent 142
  • HY-136384R
    Diethofencarb (Standard)
    Inhibitor
    Diethofencarb (Standard) is the analytical standard of Diethofencarb. This product is intended for research and analytical applications. Diethofencarb is a fungicide with strong activity against Botrytis cinerea and Benzimidazole-resistant strains of Botryis spp. Diethofencarb has a role as an antifungal agrochemical.
    Diethofencarb (Standard)
  • HY-N13892
    Alisamycin
    Inhibitor
    Alisamycin is the manumycin group of antibiotic. Alisamycin is active against Gram-positive bacteria and fungi, and has a weak antitumour activity.
    Alisamycin
  • HY-W001251R
    3,5-Dimethoxybenzoic acid (Standard)
    Inhibitor
    3,5-Dimethoxybenzoic acid (Standard) is the analytical standard of 3,5-Dimethoxybenzoic acid (HY-W001251). This product is intended for research and analytical applications. 3,5-Dimethoxybenzoic acid is an aromatic organic acid and antifungal agent. 3,5-Dimethoxybenzoic acid can also be used as an intermediate for anticancer agents. 3,5-Dimethoxybenzoic acid can be isolated from the leaves of Melia azedarach. 3,5-Dimethoxybenzoic acid exhibits antifungal activity against A. rabiei with an MIC of 0.125 mg/mL. 3,5-Dimethoxybenzoic acid has anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects.
    3,5-Dimethoxybenzoic acid (Standard)
  • HY-N9720
    Herbarin
    Inhibitor
    Herbarin is a quinone antibiotic. Herbarin complex has anti-Gram-positive bacteria, negative bacteria, Citrus Canker xanthomonas, potato early blight, Aspergillus Niger, Decaprous and other fungal activities.
    Herbarin
  • HY-167641
    Malvone A
    Inhibitor
    Malvone A is an antifungal compound found in Malva sylvestris, with an ED50 of 24 μg/mL against V. dahliae. Malvone A may be used for research in the field of anti-infective agents.
    Malvone A
  • HY-135442
    Simeconazole
    Inhibitor
    Simeconazole is a demethylation inhibitor-class fungicide. Simeconazole prevents the infection of barley leaves by Blumeria graminis f sp hordei, inhibits the development of powdery mildew on barley and cucumber leaves, and exhibits cuticular membrane permeability in tomato fruits. Simeconazole can be used in research related to barley powdery mildew and cucumber powdery mildew.
    Simeconazole
  • HY-B1324R
    Oxiconazole nitrate (Standard)
    Inhibitor
    Oxiconazole nitrate (Standard) is the analytical standard of Oxiconazole nitrate. This product is intended for research and analytical applications. Oxiconazole (Ro 13-8996) nitrate is a broad spectrum anti-fungal agent which can inhibit the growth of Candida, Aspergillus and Trichophyton. Oxiconazole nitrate is also a highly efficacious activator of CYP3A4 transactivation, which could be antagonized by Rifampicin (HY-B0272) in a competitive manner. Oxiconazole nitrate exhibits inhibitory effect against colorectal cancer (CRC) via peroxiredoxin-2 (PRDX2)-mediated autophagy arrest.
    Oxiconazole nitrate (Standard)
  • HY-N15583
    Purpuride
    Inhibitor
    Purpuride is a sesquiterpene ester found in aciduric fungi. Purpuride shows moderate antibacterial activities against Candida albicans, Enterobacter aerogenes and Pseudomonas aeruginosa with MIC values ranging from 1.2 to 3.3 μM.
    Purpuride
  • HY-121935R
    Tecnazene (Standard)
    Inhibitor
    Tecnazene (Standard) is the analytical standard of Tecnazene. This product is intended for research and analytical applications. Tecnazene is a dinitroaromatic fungicide and plant growth regulator. Tecnazene binds irreversibly to human skin tissues and exhibits acute toxicity in Rattus norvegicus (brown rat). Tecnazene exerts sprouting-inhibiting and antifungal activities by inhibiting the sprouting of potato tuber buds and blocking the growth and reproduction of fungi that cause dry rot. Tecnazene has significant antifungal and sprouting-inhibiting activities, and shows high toxicity to aquatic organisms such as freshwater fish and crustaceans. Tecnazene is used for sprouting inhibition and dry rot control during potato storage.
    Tecnazene (Standard)
  • HY-N14550
    Cyclogregatin
    Inhibitor
    Cyclogregatin has anti-bacterial and fungal activity. Cyclogregatin inhibits airy ascites carcinoma with a MIC of 10 μg/mL .
    Cyclogregatin
  • HY-N14544
    Orchinol
    Inhibitor
    Orchinol is an aromatic derivative of antibiotic and has antifungal activity.
    Orchinol
  • HY-W979008
    (+)-Isopinocampheol
    Inhibitor
    (+)-Isopinocampheol is an oxygenated monoterpenoid that is important in the chemical ecology of bark beetles.
    (+)-Isopinocampheol
  • HY-W712766
    Dodemorph
    Inhibitor
    Dodemorph is a fungicide. Dodemorph exerts antifungal effects by inhibiting ergosterol biosynthesis. Dodemorph can be used in studies related to fungal mildew in rose cultivation.
    Dodemorph
Cat. No. Product Name / Synonyms Application Reactivity