Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2751)
Related Products (2751)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Antifungal agent 87
0 ImagesCat. No.: HY-149778CAS No.: 692730-21-5Antifungal agent 87(10) acts as a highly potent PDT antimycotic photosensitizer (PDT-IC50 = 1 nM for T. rubrum).
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Neoenactin B2
0 ImagesCat. No.: HY-N14839CAS No.: 88231-87-2Neoenactin B2 has strong anti-yeastlike and filamentous fungal effects.
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Antifungal agent 104
0 ImagesCat. No.: HY-163693CAS No.: 3048597-67-4Antifungal agent 104 (Compound 5e) exhibits antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani and Botrytis cinerea, with EC50 of 1.52 μg/mL, 0.06 μg/mL and 15.69 μg/mL, respectively. Antifungal agent 104 exhibits low cytotoxicity to human renal cell 239A (6.28-100 mM).
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Neobulgarone C
0 ImagesCat. No.: HY-N14809CAS No.: 315209-17-7Neobulgarone C is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone C can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
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Econazole nitrate-d6
0 ImagesCat. No.: HY-W705651CAS No.: 2469273-41-2Econazole nitrate-d6 is deuterium labeled Econazole (nitrate). Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.
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Frequentin
0 ImagesCat. No.: HY-114881CAS No.: 29119-03-7Synonyms: NSC 246118Frequentin, a secondary metabolite produced by Penicillium janthinellum, is influenced by environmental conditions such as cadmium nitrate and sodium chloride concentrations. In cadmium nitrate-free medium, P. janthinellum produces cyclopenin, carlosic acid, erythroskyrin, kojic acid, and patulin. At 100 ppm cadmium nitrate, it produces cyclopenin, carlosic acid, frequentin, and islandicin. In the presence of sodium chloride, frequentin is produced at 2% and 3% concentrations. These findings indicate that frequentin production is sensitive to specific environmental stressors, highlighting its potential variability under different growth conditions.
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6-O-Methylreticulol
0 ImagesCat. No.: HY-N13291CAS No.: 24350-93-46-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China.
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Naphthoquinomycin B
0 ImagesCat. No.: HY-N14833CAS No.: 101190-61-8Naphthoquinomycin B is an Ansa antibiotic with anti-Gram-positive bacteria and fungi activity, and can inhibit the synthesis of E. coli fatty acids.
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Antifungal agent 159
0 ImagesCat. No.: HY-183091Antifungal agent 159 is an antifungal agent with broad-spectrum activity against phytopathogenic fungi. Antifungal agent 159 binds tightly to the active sites of exo-β-(1,3)-glucanase, topoisomerase II-DNA-nucleotide, dihydrofolate reductase, sterol 14-α demethylase and chitin synthase. Antifungal agent 159 can be used in studies related to phytopathogenic fungal infections.
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LY 121019
0 ImagesCat. No.: HY-105267CAS No.: 79404-91-4LY 121019 is a semi-synthetic antifungal antibiotic with strong anticandida activity with MIC50 value of 0.625 μg/mL.
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Vaccarin C
0 ImagesCat. No.: HY-169684CAS No.: 177602-12-9Vaccarin C (Compound VIII) is a cycloheptapeptide with good antifungal activity against pathogenic fungi and dermatophytes M. audouinii and T. mentagrophytes with MIC values of 6 µg/mL. Vaccarin C also has high cytotoxicity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines with IC50 values of 3.35 and 5.72 μM, respectively.
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Clavamycin B
0 ImagesCat. No.: HY-N13996CAS No.: 103080-36-0Clavamycin B has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
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Amidomycin
0 ImagesAmidomycin is an antibiotic active primarily against yeast.
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Hypelcin A-Ⅰ
0 ImagesCat. No.: HY-N14254CAS No.: 93397-17-2
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(-)-Bornyl acetate (Standard)
0 ImagesCat. No.: HY-N0756ARCAS No.: 5655-61-8Synonyms: L-(-)-Bornyl acetate (Standard)(-)-Bornyl acetate (Standard) is the analytical standard of (-)-Bornyl acetate. This product is intended for research and analytical applications. (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.
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Chondramide B
0 ImagesCat. No.: HY-N14027CAS No.: 172430-61-4
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Furaneol (Standard)
0 ImagesFuraneol (Standard) is the analytical standard of Furaneol. This product is intended for research and analytical applications. Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines.
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Fenchyl alcohol (Standard)
0 ImagesFenchyl alcohol is a monoterpene alcohol that can be used as a fragrance. Fenchyl alcohol has antifungal activity and can inhibit the formation of biofilms and hyphae of Candida albicans. Fenchyl alcohol also has a strong inhibitory effect on the rumen microbial activity of sheep and deer.
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5-Phenyllevulinic acid
0 ImagesCat. No.: HY-W714837CAS No.: 3183-15-1Synonyms: 4-Oxo-5-phenylpentanoic acid; 5-Phenyl-4-oxopentanoic acid5-Phenyllevulinic acid (4-Oxo-5-phenylpentanoic acid) is an endogenous fungal metabolite with inhibitory activity against the bacterium B. megaterium, the plant pathogenic fungus S. tritici, and the alga C. fusca. 5-Phenyllevulinic acid is also an intermediate in the synthesis of σ receptor ligands. 5-Phenyllevulinic acid holds potential for research in the field of anti-infection studies .
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Capoamycin
0 ImagesCat. No.: HY-121245CAS No.: 97937-29-6Capoamycin is an antibiotic. Capoamycin shows antimicrobial and antitumor activity.
