Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2741)
Related Products (2741)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Tioconazole (Standard)
0 ImagesSynonyms: UK-20349 (Standard)Tioconazole (Standard) is the analytical standard of Tioconazole. This product is intended for research and analytical applications. Tioconazole (UK-20349) is an antifungal imidazole derivative with broad spectrum activity. Tioconazole has inhibitory active aginst several dermatophytes and several yeasts with MIC50s <3.12 mg/L and <9 mg/L, respectively.
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Fludioxonil-13C3
0 ImagesCat. No.: HY-W021040SCAS No.: 1185003-07-9Synonyms: CGA-173506-13C3Fludioxonil-13C3 (CGA-173506-13C3) is 13C labeled Fludioxonil. Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.
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Haematocin
0 ImagesCat. No.: HY-N14716CAS No.: 262425-39-8Haematocin can inhibit the germination of Pyricularia oryzae spore.
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NMT-IN-9
0 ImagesCat. No.: HY-187518CAS No.: 3134912-65-2NMT-IN-9 is an arylpyrrolidone-based NMT inhibitor with an IC50 of 93.20 nM and a KD of 5.57 × 10-9 M against NMT. NMT-IN-9 exhibits broad-spectrum antifungal activity against Candida albicans, Candida glabrata, Candida tropicalis, Cryptococcus neoformans and Aspergillus fumigatus, with an MIC of 2-16 μg/mL, and retains activity against fluconazole-resistant Candida isolates, with an MIC of 8-16 μg/mL. NMT-IN-9 induces intracellular ROS accumulation, mitochondrial membrane depolarization, DNA damage, apoptosis and necrotic cell death in fungal cells, and disrupts fungal cell integrity. NMT-IN-9 can be used for studies on NMT-targeted antifungal mechanisms and fluconazole-resistant Candida infections.
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Dermaseptin-S2
0 ImagesCat. No.: HY-P5593CAS No.: 151896-13-8Dermaseptin-S2 is an antimicrobial peptide derived from frog skin against filamentous fungi.
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Hordatine A
0 ImagesCat. No.: HY-W752450CAS No.: 7073-64-5Hordatine A is an active ingredient that can be extracted from barley. Hordatine A has antifungal activity. Hordatine A can be used for research on fungal infections.
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ME1111 (Standard)
0 ImagesCat. No.: HY-108012RCAS No.: 1391758-52-3ME1111 (Standard) is the analytical standard of ME1111 (HY-108012). This product is intended for research and analytical applications. ME1111 is an antifungal agent that is active against dermatophytes. ME1111 is an inhibitor of the succinate dehydrogenase of Trichophyton species. ME1111 has an excellent ability to penetrate human nails and is used for onychomycosis research.
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Hydroxymethyl dioxoazabicyclooctane
0 ImagesCat. No.: HY-W078710CAS No.: 6542-37-6Hydroxymethyl dioxoazabicyclooctane is commonly used in cosmetic research and development to control the growth of microorganisms (such as bacteria and fungi).
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Imazalil (Standard)
0 ImagesSynonyms: Enilconazole (Standard)Imazalil (Standard) is the analytical standard of Imazalil. This product is intended for research and analytical applications. Imazalil (Enilconazole) is a fungicide. Imazalil has oral activity and strongly activates mPXR but not mCAR in mouse liver. Imazalil is commonly used to protect various agricultural crops against fungal attack. Imazalil induces developmental abnormalities, gut microbiota dysbiosis, and hepatic metabolism disorder.
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Yck2-IN-1
0 ImagesCat. No.: HY-168998CAS No.: 401816-26-0Yck2-IN-1 (Compound 2a) is an inhibitor of the fungal Candida albicans Yck2 kinase. It exhibits an IC50 of approximately 80 nM against Yck2 and a MIC80 of 12.5 µM against C. albicans, with good metabolic stability (66% remaining in mouse liver microsomes). In a mouse model of drug-resistant candidiasis, Yck2-IN-1 significantly reduced fungal burden in the kidneys. Yck2-IN-1 holds promise for research in the field of antifungal infection.
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Micafungin sodium (Standard)
0 ImagesSynonyms: FK 463 sodium (Standard)Micafungin (sodium) (Standard) is the analytical standard of Micafungin (sodium). This product is intended for research and analytical applications. Micafungin sodium (FK 463 sodium) is an antifungal agent which inhibits 1, 3-beta-D-glucan synthesis.
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Azoxybacilin
0 ImagesCat. No.: HY-N15023CAS No.: 157998-96-4Azoxybacilin can inhibit the sulfur fixation reaction in methionine biosynthesis and has strong anti-filamentous fungal activity.
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Irtemazole
0 ImagesCat. No.: HY-106333CAS No.: 129369-64-8Synonyms: R 60844Irtemazole is an orally active antifungal agent. Irtemazole possesses uricosuric effect. Irtemazole is used in the research for blastomycosis, histoplasmosis, and aspergillosis.
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1-Monomyristin (Standard)
0 Images1-Monomyristin, extracted from Serenoa repens, inhibits the hydrolysis of 2-oleoylglycerol (IC50=32 μM) and fatty acid amide hydrolase (FAAH) activity (IC50=18 μM). 1-Monomyristin shows antibacterial activity against Staphylococcus aureus and Aggregatibacter actinomycetemcomitans and also antifungal activity against Candida albicans.
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(RS)-Sakuranetin
0 Images(RS)-Sakuranetin is the racemate of Sakuranetin (HY-N3006).
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Ethonam
0 ImagesCat. No.: HY-184509CAS No.: 15037-44-2Ethonam is the non-salt form of Ethonam nitrat. Ethonam nitrat exhibits antifungal activity against Microsporum canis, Trichophyton mentagrophytes and Trichophyton rubrum. Ethonam can be used in research related to fungal infections.
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δ-Dodecalactone
0 ImagesCat. No.: HY-W009815CAS No.: 713-95-1Synonyms: δ-Laurolactoneδ-Dodecalactone can be obtained from L. plantarum AF1. δ-Dodecalactone exhibits potent antifungal activity against molds Aspergillus flavus, A. fumigatus, A. petrakii, A. ochraceus, A. nidulans, and Penicillium roqueforti. δ-Dodecalactone is a flavoring compound.
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Flumorph (Standard)
0 ImagesCat. No.: HY-17521RCAS No.: 211867-47-9Synonyms: SYP-L190 (Standard)Flumorph (Standard) is the analytical standard of Flumorph. This product is intended for research and analytical applications. 0
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Butoconazole nitrate (Standard)
0 ImagesSynonyms: RS 35887 (Standard)Butoconazole (nitrate) (Standard) is the analytical standard of Butoconazole (nitrate). This product is intended for research and analytical applications. Butoconazole nitrate (RS 35887), an imidazole antifungal agent, is active against Candida spp. and effective against vaginal infections due to Candida albicans. Butoconazole nitrate is presumed to function as other imidazole derivatives via inhibition of steroid synthesis.
