Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Butenafine-d4
0 ImagesCat. No.: HY-114518S2CAS No.: 1653964-70-5Synonyms: KP363-d4Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent. Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor.
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Aminoacyl tRNA synthetase-IN-4
0 ImagesCat. No.: HY-128189CAS No.: 342017-94-1Aminoacyl tRNA synthetase-IN-4 (Compound 1l) is an inhibitor of Aminoacyl tRNA synthetase, with an IC50 of 0.026 μM for C.albicans prolyl-tRNA synthetase. Aminoacyl tRNA synthetase-IN-4 can be used for antifungal research.
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Chloranil (Standard)
0 ImagesSynonyms: Tetrachloro-p-benzoquinone (Standard); TCBQ (Standard)Chloranil (Standard) is the analytical standard of Chloranil. This product is intended for research and analytical applications. Chloranil, an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells.
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Heneicosane (Standard)
0 ImagesHeneicosane (Standard) is the analytical standard of Heneicosane (HY-W089845). This product is intended for research and analytical applications. Heneicosane is a royal-specific pheromone of insects (such as subterranean termites) and is an identification signal for queens and kings in termites. Heneicosane mediates royal recognition and the maintenance of social division of labor by being sensed by worker ants and triggering vibrations and antennal behaviors. Heneicosane can exert anti-inflammatory, analgesic and antipyretic activities by inhibiting the release of inflammatory mediators (such as prostaglandins and cytokines). At the same time, Heneicosane can also inhibit the mycelial growth of aflatoxin-producing fungi and inhibit the production of aflatoxin. Heneicosane can be used in insect chemical ecology research to analyze the regulatory mechanism of termite social behavior, and is also a potential target for new anti-inflammatory drugs.
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Tricrozarin A
0 ImagesCat. No.: HY-N15334CAS No.: 107817-60-7Tricrozarin A is a Naphthazarin (HY-N7526) derivative, which is found in fresh bulbs of Tritonia crocosmaeflora. Tricrozarin A exhibits antimicrobial activity against gram-positive bacteria, fungi, and yeast.
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Filipin III (Standard)
0 ImagesFilipin III (Standard) is the analytical standard of Filipin III (HY-N6718). This product is intended for research and analytical applications. Filipin III is the major component of Filipin, a 28-membered ring pentaene macrolide antifungal antibiotic produced by S. filipinensis, S. avermitilis and S. miharaensis. Filipin interacts with membrane sterols causing the alteration of membrane structure.
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Eugenol acetate-d3
0 ImagesCat. No.: HY-W014612SSynonyms: Acetyleugenol-d3Eugenol acetate-d3 is the deuterated labeled Eugenol acetate (HY-W014612). Eugenol acetate (Eugenyl acetate) is an antibacterial, anticancer, anti-inflammatory and antioxidant. Eugenol acetate inhibits NF-κB and enhances the expression of p53 and p21 (WAF1). Eugenol acetate can prevent chemically induced skin cancer, inhibit cancer cell proliferation and induce apoptosis.
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P-gp-IN-34
0 ImagesCat. No.: HY-181114CAS No.: 2743456-25-7P-gp-IN-34 (compound 4a) is an Mdr1p (Mdr1 pump) inhibitor. P-gp-IN-34 inhibits yeast to hyphal shift in Candida albicans. P-gp-IN-34 can be used for the research of candidiasis.
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Bitertanol (Standard)
0 ImagesCat. No.: HY-118216RCAS No.: 55179-31-2Synonyms: Biloxazol (Standard)Bitertanol (Standard) is the analytical standard of Bitertanol. This product is intended for research and analytical applications. Bitertanol (Biloxazol) is a potent antifungal agent. Bitertanol also is an CYP1A1, CYP2B, and CYP3A inducer in vivo and an CYP1A inhibitor in vitro.
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(1-Aminopropyl)phosphonic acid
0 ImagesCat. No.: HY-184030CAS No.: 14047-23-5(1-Aminopropyl) phosphonic acid is a phosphorus-containing amino acid fungicide with both protective and therapeutic effects, and it can be used in the research of fungus-related disorders.
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Sulfacetamide sodium monohydrate
0 ImagesSulfacetamide (Sulphacetamide) sodium monohydrate is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium monohydrate has antifungal and antibacterial activities.
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Ac-CoA-IN-1
0 ImagesCat. No.: HY-181784Ac-CoA-IN-1 is an acyl-AMP phosphate analog and weak inhibitor of Candida albicans acetyl-CoA synthetase 2, with no activity against Cryptococcus neoformans acetyl-CoA synthetase 1. Ac-CoA-IN-1 crystallizes with Cryptococcus neoformans ACS1 enzyme to yield structural insight for inhibitor design. Ac-CoA-IN-1 can be used for the research of fungal infections.
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Propiconazole-d7
0 ImagesCat. No.: HY-B0847SCAS No.: 1246818-14-3Propiconazole-d7 is the deuterium labeled Propiconazole. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption. Propiconazole inhibits S. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC50s=0.04 and >200 μM, respectively). Propiconazole inhibits the growth of T. deformans and R. stolonifer (ED50s=0.073 and 4.6 μg/mL, respectively). Propiconazole increases production of reactive oxygen species (ROS).
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SDH-IN-37
0 ImagesCat. No.: HY-178799CAS No.: 3085095-58-2SDH-IN-37 (Compound A37) is a potent SDH inhibitor, with an IC50 value of 0.0263 μM. SDH-IN-37 is also an antifungal agent. SDH-IN-37 demonstrates antifungal activities against Rhizoctonia solani, S. sclerotiorum and F. graminearum, with EC50 values of 0.0144, 0.882 and 1.99 μg/mL, respectively.
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4-Dodecyl-2,6-dimethylmorpholine
0 ImagesCat. No.: HY-W043791CAS No.: 1704-28-54-Dodecyl-2,6-dimethylmorpholine is a morpholine fungicide and plant-growth regulator. 4-Dodecyl-2,6-dimethylmorpholine targets phytopathogenic fungi including Oomycetes, Ascomycetes and Basidiomycetes. 4-Dodecyl-2,6-dimethylmorpholine acts synergistically with acylalanine fungicides to enhance antifungal efficacy and regulate plant growth. 4-Dodecyl-2,6-dimethylmorpholine can be applied to the study of plant fungal diseases and phytopathogenic fungal infections.
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Bulnesol
0 ImagesCat. No.: HY-N10014CAS No.: 22451-73-6Bulnesol is a sesquiterpenoid that can be isolated from Salvia dorystaechas. Bulnesol inhibits the activity of Fusarium moniliforme with an EC50 value of 0.6 mg/mL. Bulnesol can be used for the research of fungal infection.
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Mandestrobin
0 ImagesCat. No.: HY-138439CAS No.: 173662-97-0Mandestrobin is a fungicide that exerts fungal killing activity by inhibiting mitochondrial respiratory chain complex III. Mandestrobin exhibits differential fungicidal activity between its enantiomers, and the R-enantiomer possesses stronger activity than the S-enantiomer. Mandestrobin is used in studies related to fungal infections and the agricultural field.
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3-Piperidinopropiophenone hydrochloride
0 Images3-Piperidinopropiophenone (hydrochloride) (Compound 2) is a mono Mannich base derived from acetophenone and has antifungal activity.
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Tropolone (Standard)
0 ImagesTropolone is a seven-membered non-benzenoid aromatic compound, which is the precursor of many Azulene derivatives. Tropolone is a potent mushroom tyrosinase inhibitor with an IC50 value of 0.4 μM. Its inhibitory effect can be achieved by dialysis or excess CU2+ Reversa. Tropolone exhibits broad anti-viral and anti-fungal activity and is synergistic upon co-treatment with nucleos(t)ide analog drugs. Tropolone is a promising candidate for research in osteosarcoma.
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RWJ-49815
0 ImagesCat. No.: HY-123779CAS No.: 193282-45-0RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor. RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections.
