Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Darlucin A
0 ImagesCat. No.: HY-N14150CAS No.: 162341-15-3Darlucin A has antibacterial and fungi activity, and weak cytotoxicity.
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Mazethramycin
0 ImagesCat. No.: HY-129234CAS No.: 68373-96-6Mazethramycin is an antitumor antibiotic that exerts its antitumor effect by interfering with cellular DNA replication and RNA synthesis. Mazethramycin can be used in cancer research.
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Cyclamidomycin
0 ImagesCat. No.: HY-165154CAS No.: 35663-85-5Synonyms: Desdanine; Pyracrimycin ACyclamidomycin (Desdanine) is an acrylamide antibiotic with antibacterial activity. Cyclamidomycin inhibits nucleoside diphosphate kinase and pyruvate kinase (in E. coli) and oxidative phosphorylation in rat liver mitochondria. Cyclamidomycin is active against S. aureus, M. flavus, S. lutea, B. subtilis, E. coli, S. flexneri, S. typhosa, P. vulgaris, and K. pneumoniae (MICs=3.12-25 mg/ml).
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Fosfazinomycin B
0 ImagesCat. No.: HY-N14408CAS No.: 87423-11-8Fosfazinomycin B has the activity of resisting plant pathogenic fungi such as Xanthomonas oryzae.
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Hypelcin A-IV
0 ImagesCat. No.: HY-N14266CAS No.: 93397-15-0
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8(R)-Hydroxylinoleic acid
0 ImagesCat. No.: HY-N16867CAS No.: 138231-04-6Synonyms: 8-HPODE; PsiBα8(R)-Hydroxylinoleic acid (8-HPODE; PsiBα) is an oxygenated unsaturated C18 fatty acid that regulates fungal sporulation. 8(R)-Hydroxylinoleic acid increases the level of ascospores and decreases the level of conidia in fungi. 8(R)-Hydroxylinoleic acid can be used in studies related to fungi.
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Dithianon (Standard)
0 ImagesDithianon (Standard) is the analytical standard of Dithianon. This product is intended for research and analytical applications. Dithianon is a broad-spectrum anthraquinone fungicide with good adherence to the surface of leaves and fruits. Dithianon is used to control several several fungal of some fruits and vegetables, as anthracnose (Colletotrichum sp., Elsinoe ampelina), mildew (Plasmopara viticola), phomopsis (Phomopsis viticola), among others.
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Aspergillus niger-IN-1
0 ImagesAspergillus niger-IN-1 (Compound 17), a derivative of thiazolidine-2,4-dione, acts as an antimicrobial agent. Aspergillus niger-IN-1 exhibited antimicrobial activity against various bacterial and fungal strains, including Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli, Salmonella typhi, Candida albicans and Aspergillus niger, with MIC values of 11.3, 5.65, 11.3, 5.65, 5.65, 5.65, and 5.65 μM/mL, respectively .
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Bagremycin B
0 ImagesCat. No.: HY-N13963CAS No.: 93316-63-3Bagremycin B is found in the strain of Streptomyce sp. Tu 4128. Bagremycin B has weak activity against Gram-positive bacteria, Saccharomyces cerevisiae and Candida albicans.
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Antifungal agent 181
0 ImagesCat. No.: HY-189383Antifungal agent 181 is an Antifungal agent. Antifungal agent 181 disrupts the plasma membrane integrity of Sclerotinia sclerotiorum, leading to electrolyte leakage and mycelial damage. Antifungal agent 181 exhibits protective efficacy against Sclerotinia sclerotiorum on rapeseed leaves, reducing lesion expansion.
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Bromomonilicin
0 ImagesCat. No.: HY-171796CAS No.: 101023-71-6Bromomonilicin is a selective fungal cell membrane inhibitor. Bromomonilicin exerts antifungal activity by disrupting fungal cell membrane integrity. Bromomonilicin is promising for research of plant pathogenic fungal infections (e.g., Monilinia fructicola-induced brown rot) and superficial mycoses (e.g., dermatophyte infections).
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Gageotetrin B
0 ImagesCat. No.: HY-P5705CAS No.: 1536405-81-8Gageotetrin B has antimicrobial activities. Gageotetrin B is more active against fungi compared to bacteria with MIC values of 0.01-0.04 μM.
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2,7-Dihydroxynaphthalene (Standard)
0 ImagesSynonyms: 2,7-DHN (Standard); Naphthalene-2,7-diol (Standard)2,7-Dihydroxynaphthalene (Standard) (2,7-DHN (Standard)) is the analytical standard of 2,7-Dihydroxynaphthalene (HY-W015451). This product is intended for research and analytical applications. 2,7-Dihydroxynaphthalene (2,7-DHN) is a substrate of a new group of aromatic prenyltransferases in fungi and can be catalyzed to undergo a regiospecific prenylation reaction. 2,7-Dihydroxynaphthalene can undergo reactions such as oxidation and substitution.
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Ternidazole hydrochloride (Standard)
0 ImagesTernidazole hydrochloride (Standard) is the analytical standard of Ternidazole hydrochloride (HY-136436). This product is intended for research and analytical applications. Ternidazole hydrochloride is a nitroimidazole Antibiotic with anti-pathogenic microbial activity. Ternidazole hydrochloride kills and inhibits the visible growth of Clostridium perfringens type A in vitro. Ternidazole hydrochloride helps improve the therapeutic efficacy against bacterial vaginosis, candidal vaginitis and mixed vaginitis. Ternidazole hydrochloride effectively alleviates chronic alcoholism. Ternidazole hydrochloride can be used in research related to vaginitis, pathogenic microbial infections and chronic alcoholism.
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Chandrananimycin A
0 ImagesCat. No.: HY-N14603CAS No.: 664355-12-8Chandrananimycin A has anti-mucor activity, as well as anti-tumor cell activity such as CCL HT29, MFXF 529L, MACL McF-7.
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6-Chloro-2-benzoxazolinone
0 ImagesSynonyms: 6-Chlorobenzo[d]oxazol-2(3H)-one6-Chloro-2-benzoxazolinone (6-Chlorobenzo[d]oxazol-2 (3H)-one) is a derivative of DIMBOA (HY-N7432) and an antibacterial agent. The minimum inhibitory concentration (MIC) of 6-Chloro-2-benzoxazolinone against Ralstonia solanacearum is 100 mg/L, and its minimum bactericidal concentration (MBC) is 500 mg/L. 6-Chloro-2-benzoxazolinone reduces biofilm formation and inhibits swarming motility of *Ralstonia solanacearum*. It can be used for the research of bacterial wilt.
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E5700
0 ImagesCat. No.: HY-123746CAS No.: 332132-39-5E5700 is an orally active squalene synthase inhibitor, antimalarial agent and antifungal agent with an IC50 of 0.49 nM (without PPi) against squalene synthase from T. cruzi epimastigotes. E5700 shows antiparasitic activities against Trypanosoma cruzi. E5700 inhibits the growth and alters the lipid prolife and the ultrastructure of a multiple agent-resistant C. tropicalis strain. E5700 is a potent and selective inhibitor of the growth of Leishmania amazonensis.
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3-Methylcarbazole (Standard)
0 ImagesCat. No.: HY-W047478RCAS No.: 4630-20-0Synonyms: NSC 10154 (Standard)3-Methylcarbazole (NSC 10154) Standard is the analytical standard of 3-Methylcarbazole (HY-W047478). This product is intended for research and analytical applications. 3-Methylcarbazole (NSC 10154) is a carbazole alkaloid with an IC50 of 25 μg/mL against human fibrosarcoma cells. 3-Methylcarbazole inhibits mycelial growth and conidial germination of a variety of phytopathogenic fungi. 3-Methylcarbazole exhibits anti-inflammatory and antitumor activities. 3-Methylcarbazole can be used in studies related to fibrosarcoma, phytopathogenic fungal infections and inflammatory diseases.
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Etaconazol
0 ImagesCat. No.: HY-W714186CAS No.: 60207-93-4Synonyms: EtaconazoleEtaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD+/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity.
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Anethole (Standard)
0 ImagesSynonyms: Anise camphor (Standard); p-Propenylanisole (Standard); Isoestragole (Standard)Anethole (Standard) is the analytical standard of Anethole. This product is intended for research and analytical applications. Anethole is a type of orally active aromatic compound that is widely found in nature and used as a flavoring agent. Anethole possesses anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, anesthetic, estrogenic, central nervous system depressant, hypnotic, insecticidal, and gastroprotective effects. Anethole can be used in the study of oxidative stress-related skin diseases and prostate cancer.
