Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2769)
Related Products (2769)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Ferron (Standard)
0 ImagesSynonyms: 8-Hydroxy-7-iodo-5-quinolinesulfonic acid (Standard)Ferron (Standard) is the analytical standard of Ferron. This product is intended for research and analytical applications. Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
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Cyflufenamid
0 ImagesCat. No.: HY-121443CAS No.: 180409-60-3Cyflufenamid is an oxime amide fungicide. Cyflufenamid inhibits the formation of haustoria, colonies and spores of Blumeria graminis f. sp. tritici, and prevents germ tube elongation of Monilinia fructicola. Cyflufenamid is applicable to research related to powdery mildew and brown rot.
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Penoxsulam
0 ImagesCat. No.: HY-135713CAS No.: 219714-96-2Penoxsulam is an acetolactate synthase (ALS) inhibitor herbicide. Penoxsulam inhibits Candida auris acetohydroxyacid synthase (AHAS) with a Ki value of <32 nM. Penoxsulam can be used for postemergence control of annual grasses, sedges, and broadleaf weeds in rice culture. Penoxsulam can be used for the study of Candida auris infections.
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Fluxapyroxad (Standard)
0 ImagesFluxapyroxad (Standard) is the analytical standard of Fluxapyroxad. This product is intended for research and analytical applications. Fluxapyroxad is a synthetic broad-spectrum fungicide for the control of fungal diseases. It works by inhibiting succinate dehydrogenase in complex II of the mitochondrial respiratory chain, resulting in inhibition of spore germination, germ tubes and mycelia growth within the fungus target species.
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(E)-β-Farnesene-d6
0 ImagesCat. No.: HY-N7364SCAS No.: 1092965-77-9Synonyms: trans-β-Farnesene-d6(E)-β-Farnesene-d6 is deuterated labeled (E)-β-Farnesene (HY-N7364). (E)-β-Farnesene (trans-β-Farnesene) is an aphid alarm pheromone, which can be found in Phlomis aurea Decne essential oil. (E)-β-Farnesene shows good binding score with a value of -30.64 kcal/mol to the CDK2 receptor. (E)-β-Farnesene also exhibits good affinity to odorant-binding protein 3 (OBP3). (E)-β-Farnesene can be used as a feeding stimulant for the sand fly Lutzomyia longipalpis.
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Ampelopsin A
0 ImagesCat. No.: HY-117496CAS No.: 130608-11-6Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects.
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Octanal-d4
0 ImagesCat. No.: HY-N8015S2CAS No.: 1335401-91-6Octanal-d4 is deuterated labeled Octanal (HY-N8015). Octanal is a fragrant aldehyde with antioxidant and antibacterial activity. Its antifungal effect against G. citri-aurantii may be related to the disruption of cell membrane integrity and the leakage of cellular components. Additionally, Octanal exhibits cytotoxicity towards HeLa cells, with an IC50 value of 3.5 μg/mL.
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3-Hydroxypropionyl-CoA
0 ImagesCat. No.: HY-E70241CAS No.: 157786-88-43-Hydroxypropionyl-CoA is a metabolic intermediate and enzyme substrate/product that functions in multiple metabolic pathways. 3-Hydroxypropionyl-CoA serves as a substrate for 3-Hydroxypropionyl-CoA dehydratase (HY-E71752), a product of 3-hydroxypropionyl-CoA synthetase, and a hydrolysis substrate for Ehd3p. 3-Hydroxypropionyl-CoA participates in autotrophic CO2 fixation, modified β-oxidation, and reverse hydration reactions. Accumulation of 3-Hydroxypropionyl-CoA inhibits fatty acid β-oxidation at the Fox2p site and induces metabolic toxicity. 3-Hydroxypropionyl-CoA can be used in studies of hematogenously disseminated candidiasis.
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Prochloraz (Standard)
0 ImagesSynonyms: BTS 40542 (Standard)Prochloraz (Standard) is the analytical standard of Prochloraz. This product is intended for research and analytical applications. Prochloraz is an imidazole antifungal. Prochloraz is as an estrogen receptor (ER) and androgen receptor (AR) antagonist and an aromatase inhibitor with IC50 values of 25 μM, 4 μM and 0.3 μM, respectively. Prochloraz is able to activate the aryl hydrocarbon receptor (AhR) having an EC50 of 1 μM.
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Antifungal agent 124
0 ImagesCat. No.: HY-170359Antifungal agent 257 is broad spectrum antifungal. Antifungal agent 257 inhibits F. graminearum with an EC50 value of 4.15 μM.
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Neobulgarone D
0 ImagesCat. No.: HY-N14810CAS No.: 315209-18-8Neobulgarone D is an anthraquinone derivative of Neobulgaria pura HA A07-97, a fungus of the ascomycetes class. Neobulgarone D can inhibit the formation of Appressorium in Magnaporthe grisea and has weak cytotoxicity without antifungal, antibacterial or phytotoxicity.
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2-(3-Chlorophenyl)-1H-benzo[d]imidazole
![2-(3-Chlorophenyl)-1H-benzo[d]imidazole](https://file.medchemexpress.com/product_pic/hy-117150.gif "Click to View 2-(3-Chlorophenyl)-1H-benzo[d]imidazole Product Detail")
0 ImagesCat. No.: HY-117150CAS No.: 22868-35-52-(3-Chlorophenyl)-1H-benzo[d]imidazole is an antibacterial agent. 2-(3-Chlorophenyl)-1H-benzo[d]imidazole can be used in the research of bacterial infections and fungal infections.
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CYP51-IN-6
0 ImagesCat. No.: HY-136756CAS No.: 1155361-04-8CYP51-IN-2 (compound 1f), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80s of 62.5 and 15.6 ng/mL for Microsporum gypseum and Candida albicans, respectively.
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Maniwamycin B
0 ImagesCat. No.: HY-N14329CAS No.: 122547-71-1Maniwamycin B has anti-fungal effect.
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7-Hydroxytropolone
0 ImagesCat. No.: HY-W983893CAS No.: 34777-04-3Synonyms: 3-Hydroxytropolone7-Hydroxytropolone (3-Hydroxytropolone) is an antibiotic with anti-Gram-positive bacteria, negative bacteria, yeast and fungi activity, and has the effect of inhibiting 2''-O-Adenylyltransferase.
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(±)-Dunnione
0 Images(±)-Dunnione (SL 11010) is a compound with broad-spectrum antifungal activity that acts by initiating redox cycling.
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Antifungal agent 132
0 ImagesCat. No.: HY-176417Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a Ki of 180 pM.
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Complex I-IN-1
0 ImagesCat. No.: HY-184440CAS No.: 3080323-62-9Complex I-IN-1 is a novel fungicide that acts as a mitochondrial complex I inhibitor. Complex I-IN-1 regulates oxidoreductase activity, glycolysis/gluconeogenesis, methionine metabolism, and the MAPK signaling pathway in Blumeria graminis. Complex I-IN-1 is applicable to research related to wheat powdery mildew.
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Naphthalene-2,3-dicarboxaldehyde (Standard)
0 ImagesSynonyms: 2,3-Naphthalenedicarboxaldehyde (Standard); Naphthalene-2,3-dialdehyde (Standard)Naphthalene-2,3-dicarboxaldehyde (Standard) is the analytical standard for Naphthalene-2,3-dicarboxaldehyde (HY-W016288). This product is for research and analytical applications. Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis.
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Antifungal agent 85
0 ImagesCat. No.: HY-157027CAS No.: 3017207-42-7Antifungal agent 85 (compound 24f) is a potent antibacterial compound with the minimum inhibitory concentration (MIC) values between 2.5 and 10 μM against various Gram-positive bacteria.
