7149-49-7
Chemical Structure
Naphthalene-2,3-dicarboxaldehyde
Synonym(s): 2,3-Naphthalenedicarboxaldehyde; Naphthalene-2,3-dialdehyde
- CAS No.: 7149-49-7
- Formula:C12H8O2
- Molecular Weight:184.19
IUPAC Name: naphthalene-2,3-dicarbaldehyde
InChIKey: ZIPLKLQPLOWLTM-UHFFFAOYSA-N
SMILES: O=CC1=CC2=CC=CC=C2C=C1C=O
Biological Activity: Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis[1][2][3].
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Naphthalene-2,3-dicarboxaldehyde | 99.25% | Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis. | ||||||||||||||||||||
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Naphthalene-2,3-dicarboxaldehyde (Standard) | ≥98% | Naphthalene-2,3-dicarboxaldehyde (Standard) is the analytical standard for Naphthalene-2,3-dicarboxaldehyde (HY-W016288). This product is for research and analytical applications. Naphthalene-2,3-dicarboxaldehyde (NDA) is an effective inhibitor of Candida albicans aspartate semialdehyde dehydrogenase (ASADH), with a Ki value of 45 μM. Naphthalene-2,3-dicarboxaldehyde targets ASADH in the aspartate biosynthetic pathway of Candida albicans. Naphthalene-2,3-dicarboxaldehyde reacts with primary amines to generate highly fluorescent and stable derivatives. Naphthalene-2,3-dicarboxaldehyde serves as a fungistatic agent and a fluorogenic derivatization reagent. Naphthalene-2,3-Dicarboxaldehyde can be used for the research of candidiasis. | ||||||||||||||||||||
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Similarity Score 0.89
HY-D1519Naphthalene-1,2-dicarbaldehyde -
Similarity Score 0.83
HY-W012669Phthalaldehyde -
Similarity Score 0.81
HY-Y00752-Naphthaldehyde -
Similarity Score 0.81
HY-Y0075S12-Naphthaldehyde-13C -
Similarity Score 0.78
HY-W016889RCFL-137 (Standard) -
Similarity Score 0.76
HY-W016104R3-Hydroxy-2-naphthoic acid (Standard) -
Similarity Score 0.76
HY-W0051483-Amino-2-naphthoic acid -
Similarity Score 0.75
HY-W0074372-Naphthoic acid -
Similarity Score 0.75
HY-W7782402-Naphthoic acid-13C6 -
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References
- [1]. Dahal GP, et al. Aspartate semialdehyde dehydrogenase inhibition suppresses the growth of the pathogenic fungus Candida albicans. Drug Dev Res. 2020;81(6):736-744. [Content Brief]
- [2]. Nerurkar MM, et al. Selective fluorogenic derivatization of a peptide nucleic acid trimer with naphthalene-2,3-dicarboxaldehyde. J Pharm Biomed Anal. 1997;15(7):945-950. [Content Brief]
- [3]. Marra M, et al. High-performance liquid chromatographic assay of asymmetric dimethylarginine, symmetric dimethylarginine, and arginine in human plasma by derivatization with naphthalene-2,3-dicarboxaldehyde. Anal Biochem. 2003;318(1):13-17. [Content Brief]
