Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Phoslactomycin D
0 ImagesCat. No.: HY-N12679CAS No.: 122856-28-4Phoslactomycin D has weak effect against Gram-positive bacteria, but has strong effect against fungi.
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CYP51-IN-9
0 ImagesCat. No.: HY-136759CAS No.: 1155361-07-1CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candida albicans.
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Antimicrobial agent-50
0 ImagesCat. No.: HY-183705CAS No.: 177776-73-7Antimicrobial agent-50 is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC50 of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively.
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CYP51/Hsp90-IN-1
0 ImagesCat. No.: HY-170816CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis.
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MOA-stilbene
0 ImagesCat. No.: HY-187583CAS No.: 103455-29-4MOA-stilbene is an inhibitor targeting mitochondrial complex III, with fungicidal and insecticidal activities. MOA-stilbene binds to the Qo center of cytochrome b (i.e., the ubiquinol oxidation site, center o), blocking electron transport and inhibiting mitochondrial cellular respiration, thereby reducing the production of reactive oxygen species. MOA-stilbene binds to the Qi center of the chloroplast b6f-complex, inhibiting the reoxidation of reduced bH and bL hemes, the reverse electron transfer from cytochrome c + c1 and ISP to bH and bL, and the electron transfer from bH to bL.
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Buthiobate
0 ImagesCat. No.: HY-118558CAS No.: 51308-54-4Synonyms: S-1358Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops.
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2,3,5-Trimethylpyrazine-d3
0 ImagesCat. No.: HY-W010476S1CAS No.: 1082582-30-62,3,5-Trimethylpyrazine-d3 is the deuterated-labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an activator of OR5K1 with an EC50 of 65.03 μM in Hana-3A cells. 2,3,5-Trimethylpyrazine inhibits ZEN biosynthetic gene expression, disrupts cell membrane phospholipid composition, and inhibits mycelial growth. 2,3,5-Trimethylpyrazine inhibits DNA synthesis in the chorioallantoic membrane without disrupting vascular pattern formation. 2,3,5-Trimethylpyrazine inhibits ciliary beating frequency, oocyte pickup, and infundibular smooth muscle contraction in hamster oviduct explants. 2,3,5-Trimethylpyrazine is useful for research related to plant fungal infections.
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CYP51-IN-12
0 ImagesCat. No.: HY-136762CAS No.: 1155361-10-6CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
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Restricticin
0 ImagesCat. No.: HY-119465CAS No.: 135357-96-9Restricticin is a compound obtained from marine fungi, whose structure contains alkene, tetrahydropyran ring and glycine ester functional groups, and has anti-neuroinflammatory effects in lipopolysaccharide-induced BV-2 microglia by inhibiting the production of proinflammatory mediators.
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Posaconazole hydrate
0 ImagesCat. No.: HY-17373ACAS No.: 1198769-38-8Synonyms: SCH56592 hydratePosaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
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Dermaseptin-S4
0 ImagesCat. No.: HY-P5588CAS No.: 151896-15-0Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi.
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SDH-IN-39
0 ImagesCat. No.: HY-178801SDH-IN-39 (Compound A16) is a SDH inhibitor, with an IC50 value of 6.83 μg/mL. SDH-IN-39 is also an antifungal agent. SDH-IN-39 shows antifungal activity against Rhizoctonia solani (EC50 of 1.49 μg/mL), G. zeae, C. gloeosporioides, S. sclerotiorum and M. oryzae.
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Urdamycin B
0 ImagesCat. No.: HY-N8519CAS No.: 104542-46-3Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections.
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4,4-Dimethyloxazolidine
0 ImagesCat. No.: HY-W028039CAS No.: 51200-87-4
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Solavetivone
0 ImagesCat. No.: HY-N12475CAS No.: 54878-25-0Solavetivone is a Sesquiterpenoid phytoalexin and Antifungal agent. Solavetivone is isolated from stress-challenged potato plants. Solavetivone is hydroxylated by sesquiterpenoid phytoalexin hydroxylase (SPH/CYP76A2L). Solavetivone helps solanaceous plants defend against pathogens, damages plant cells after pathogen threat, and inhibits mycelial growth of Rhizoctonia solani. Solavetivone is applicable to studies related to Rhizoctonia solani infection.
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Haliangicin D
0 ImagesCat. No.: HY-N14444CAS No.: 661466-89-3Haliangicin D has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
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Daphylloside
0 ImagesDaphylloside is an iridoid isolated from the aerial parts of Galium verum. Daphylloside has antifungal activity.
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trans-11-Methyl-2-dodecenic acid
0 ImagesCat. No.: HY-130317CAS No.: 677354-24-4Synonyms: trans-δ2-11-Methyl-dodecenoic acidtrans-11-Methyl-2-dodecenic acid is a isomer of cis-11-Methyl-2-dodecenoic acid (HY-134215). cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems.
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JH-FK-08
0 ImagesCat. No.: HY-170616CAS No.: 3062848-75-0JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models.
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Ferron (Standard)
0 ImagesSynonyms: 8-Hydroxy-7-iodo-5-quinolinesulfonic acid (Standard)Ferron (Standard) is the analytical standard of Ferron. This product is intended for research and analytical applications. Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
