Buthiobate
Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops.
For research use only. We do not sell to patients.
- CAS No.: 51308-54-4
- Formula: C21H28N2S2
- Molecular Weight:372.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Buthiobate (0.4-10 μM; 30 min) potently inhibits lanosterol 14α-demethylase activity in rat liver microsomes with an IC50 of 0.4 μM, and achieves near-complete inhibition at 10 μM[1].
Buthiobate (10-6-10-4 M; 3 h) potently inhibits C-14 demethylation in ergosterol biosynthesis in cell-free homogenates of Saccharomyces cerevisiae, with the strongest effect observed at 10-4 M, resulting in accumulation of lanosterol and reduced formation of downstream sterols[2].
Buthiobate (various concentrations; 36 μM) binds to three distinct low-spin cytochrome P-450 species in rat liver microsomes with KD values ranging from 0.38 to 13.2 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51308-54-4
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Molecular Weight 372.59
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Formula C21H28N2S2
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SMILES
CCCCS/C(SCC1=CC=C(C=C1)C(C)(C)C)=N\C2=CC=CN=C2
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Synonyms
S-1358
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Buthiobate Related Classifications
HY-118558 Related Classifications
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