51308-54-4
51308-54-4
Chemical Structure
Buthiobate
Synonym(s): S-1358
- CAS No.: 51308-54-4
- Formula:C21H28N2S2
- Molecular Weight:372.59
IUPAC Name: butyl (4-(tert-butyl)benzyl) (E)-pyridin-3-ylcarbonimidodithioate
InChIKey: ZZVVDIVWGXTDRQ-BSYVCWPDSA-N
SMILES: CCCCS/C(SCC1=CC=C(C=C1)C(C)(C)C)=N\C2=CC=CN=C2
Biological Activity: Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops[1][2].
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Buthiobate | Buthiobate (S-1358) is a fungicide. Buthiobate is a cytochrome P-450 inhibitor with an IC50 of 0.4 μM. Buthiobate binds to the heme iron of cytochrome P-450 (low-spin state) via its pyridine group, thereby blocking the initial hydroxylation of the 14α-methyl group. Buthiobate is used in research on powdery mildew in agricultural and horticultural crops. | |||||||||||||||||||||
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References
- [1]. Yoshida Y, et al. Effects of buthiobate, a fungicide, on cytochrome P-450 of rat liver microsomes. Journal of pharmacobio-dynamics. 1985 Jun;8(6):432-9.
- [2]. Kato T, et al. Selective inhibition of the demethylation at C-14 in ergosterol biosynthesis by the fungicide, Denmert (S-1358). Agricultural and Biological Chemistry, 1976, 40(12): 2379-2388.
