Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2768)
Related Products (2768)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Piperanine
0 ImagesCat. No.: HY-N12118CAS No.: 23512-46-1Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum.
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Chondramide C
0 ImagesCat. No.: HY-N14037CAS No.: 172430-62-5
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A25822B
0 ImagesCat. No.: HY-121461CAS No.: 50686-98-1Synonyms: 15-AzasterolA25822B is an antifungal agent, with a MIC of 1 μM for Ascosphaera apis. A25822B causes conformational changes in mitochondria and disruption of spore membrane structure. A25822B can be used for the research of bee chalk disease.
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Antifungal agent-166
0 ImagesCat. No.: HY-184314CAS No.: 3122934-62-4Antifungal agent-166 is an antifungal agent. The combination of Antifungal agent-166 and Fluconazole exerts synergistic bacteriostatic effects against fluconazole-resistant Candida albicans. Antifungal agent-166 exhibits bacteriostatic activity against both Candida glabrata and Cryptococcus neoformans. Antifungal agent-166 reverses the fluconazole resistance of strains by downregulating ergosterol synthesis-related genes, drug resistance-related genes and virulence-related genes. Antifungal agent-166 can enhance the efficacy of Fluconazole in Galleria mellonella and mouse candidiasis models, reduce fungal load and improve survival rate. Antifungal agent-166 can be used in the research of fungal infections.
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(+)-Magnoflorine chloride (Standard)
0 ImagesSynonyms: Magnoflorine chloride (Standard); α-Magnoflorine chloride (Standard); Thalictrine chloride (Standard)(+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity.
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Sarisan
0 ImagesCat. No.: HY-116631CAS No.: 18607-93-7Synonyms: AsaricinSarisan (Asaricin) is a phenolic derivative with antifungal and insecticidal activity. Sarisan can be found in the stem bark of Ocotea opifera Mart..
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Anidulafungin-13C6
0 ImagesCat. No.: HY-13553S1Synonyms: LY303366-13C6Anidulafungin-13C6 (LY303366-13C6) is 13C labeled Anidulafungin. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
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Octacosamicin A
0 ImagesCat. No.: HY-N14526CAS No.: 122005-25-8Octacosamicin A has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
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Antifungal agent 157
0 ImagesCat. No.: HY-185178CAS No.: 2446130-20-5Antifungal agent 157 (Ex.I-339) is a heterocyclyl pyridazine compound and phytopathogenic fungi control agent. Antifungal agent 157 can be used for the research of phytopathogenic fungal infestations.
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Lawsone (Standard)
0 ImagesLawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research.
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Lambertellin
0 ImagesCat. No.: HY-124508CAS No.: 28980-51-0Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways.
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Oudermansin B
0 ImagesCat. No.: HY-N14898CAS No.: 87081-56-9Oudermansin B is an antibiotic. Oudermansin B acts on fungi to inhibit protein, RNA and DNA synthesis.
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Kresoxim-methyl (Standard)
0 ImagesCat. No.: HY-125776RCAS No.: 143390-89-0Synonyms: BAS 490 F (Standard)Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme.
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Succinate dehydrogenase-IN-11
0 ImagesCat. No.: HY-175501Succinate dehydrogenase-IN-11 (Compound A12) is a succinate dehydrogenase inhibitor with an IC50 value of 3.58 μM. Succinate dehydrogenase-IN-11 exhibits antifungal activity. Succinate dehydrogenase-IN-11 shows activity against fungi such as R. solani, B. cinerea, F. graminearum, and S. sclerotiorum in vitro. Succinate dehydrogenase-IN-11 also exerts a controlling effect on R. solani, P. pachyrhizi, and P. sorghi in vivo. Succinate dehydrogenase-IN-11 can be used in research related to antifungal applications.
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Antifungal agent 131
0 ImagesCat. No.: HY-173490Antifungal agent 131 (compound A20) is an antifungal compound with a minimum inhibitory concentration (MIC) of 64 μg/mL. Antifungal agent 131 demonstrates excellent antifungal potential when used in combination with Fluconazole (HY-B0101).
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Fenticonazole
0 ImagesCat. No.: HY-W115276CAS No.: 72479-26-6Fenticonazole is an imidazole derivative with antibacterial and antifungal activity. Fenticonazole has the potential for the research of mixed vaginitis.
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6-O-Demethyl-5-deoxyfusarubin
0 ImagesCat. No.: HY-N15012CAS No.: 132899-05-96-O-Demethyl-5-deoxyfusarubin has the ability of anti-fungal and mycoplasma.
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CYP51-IN-28
0 ImagesCat. No.: HY-179138CYP51-IN-28 (compound B9) is a CYP51 inhibitor. CYP51-IN-28 is an efficient, broad-spectrum, and low toxicity antifungal molecule. CYP51-IN-28 can be used for research on fungal infections.
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Cuevaene A
0 ImagesCat. No.: HY-N14111CAS No.: 1246172-08-6Cuevaene A can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene A displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
