Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2750)
Related Products (2750)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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TPS1-IN-1
0 ImagesCat. No.: HY-173402CAS No.: 3110357-76-8TPS1-IN-1 (Compound O1) is a highly potent and broad-spectrum TPS1 inhibitor. TPS1-IN-1 with IC50s of 14.73 μM for MoTPS1 (TPS1 of M oryzae) and 59.99 μM for BcTPS1 (TPS1 of B cinerea), respectively. TPS1-IN-1 exerts a broad-spectrum fungicidal effect by interfering with spore germination, appressorium formation, and turgor pressure accumulation of fungi. TPS1-IN-1 has good safety and has the potential to be a novel fungicide candidate compound.
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(S)-2-Hydroxy-3-phenylpropanoic acid (Standard)
0 ImagesSynonyms: L-(-)-3-Phenyllactic Acid (Standard)(S)-2-Hydroxy-3-phenylpropanoic acid (Standard) is the analytical standard of (S)-2-Hydroxy-3-phenylpropanoic acid. This product is intended for research and analytical applications. (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria.
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Chondramide A
0 ImagesCat. No.: HY-N14013CAS No.: 172430-60-3
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CYP51-IN-31
0 ImagesCat. No.: HY-179483CYP51-IN-31 (compound T24) is a selective CYP51 inhibitor with potent and broad-spectrum antifungal activity, including efficacy against drug-resistant fungal strains. CYP51-IN-31 exhibits fungicidal activity against Candida parapsilosis, anti-biofilm activity, and the ability to inhibit fungal morphological transitions. CYP51-IN-31 can be used for infection research.
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Democonazole
0 ImagesCat. No.: HY-167081CAS No.: 70161-09-0Democonazole is an imidazole antifungal agent that blocks ergosterol synthesis by inhibiting CYP450 14α-lanosterol demethylase (CYP51), thereby disrupting the integrity and fluidity of fungal cell membranes. Democonazole is lipophilic, which enhances its ability to penetrate fungal cell membranes and inhibit ergosterol synthesis. Democonazole can be used in studies related to fungal infections.
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Phyllosinol
0 ImagesCat. No.: HY-N14888CAS No.: 24292-29-3Phyllosinol is an antifungal antibiotic.
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CYP51-IN-32
0 ImagesCat. No.: HY-181511CAS No.: 205251-67-8CYP51-IN-32 is an antifungal agent with an IC50 of 0.331 μM against CYP51 of Candida albicans. CYP51-IN-32 releases hydrogen sulfide (H2S) and inhibits hyphal formation and biofilm development of Candida albicans. CYP51-IN-32 can be formulated into PEG-based nanovesicles. CYP51-IN-32 is applicable to the research of Candida albicans infection.
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Geninthiocin
0 ImagesCat. No.: HY-135480CAS No.: 158792-27-9Geninthiocin is a thiopeptide with antibacterial and antifungal activities. Geninthiocin is a tipA promoter.
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Piperanine
0 ImagesCat. No.: HY-N12118CAS No.: 23512-46-1Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum.
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Chondramide C
0 ImagesCat. No.: HY-N14037CAS No.: 172430-62-5
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A25822B
0 ImagesCat. No.: HY-121461CAS No.: 50686-98-1Synonyms: 15-AzasterolA25822B is an antifungal agent, with a MIC of 1 μM for Ascosphaera apis. A25822B causes conformational changes in mitochondria and disruption of spore membrane structure. A25822B can be used for the research of bee chalk disease.
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Antifungal agent-166
0 ImagesCat. No.: HY-184314CAS No.: 3122934-62-4Antifungal agent-166 is an antifungal agent. The combination of Antifungal agent-166 and Fluconazole exerts synergistic bacteriostatic effects against fluconazole-resistant Candida albicans. Antifungal agent-166 exhibits bacteriostatic activity against both Candida glabrata and Cryptococcus neoformans. Antifungal agent-166 reverses the fluconazole resistance of strains by downregulating ergosterol synthesis-related genes, drug resistance-related genes and virulence-related genes. Antifungal agent-166 can enhance the efficacy of Fluconazole in Galleria mellonella and mouse candidiasis models, reduce fungal load and improve survival rate. Antifungal agent-166 can be used in the research of fungal infections.
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(+)-Magnoflorine chloride (Standard)
0 ImagesSynonyms: Magnoflorine chloride (Standard); α-Magnoflorine chloride (Standard); Thalictrine chloride (Standard)(+)-Magnoflorine (chloride) (Standard) is the analytical standard of (+)-Magnoflorine (chloride). This product is intended for research and analytical applications. Magnoflorine chloride (Magnoflorine chloride), an aporphine alkaloid found in Magnolia or Aristolochia, reduces the formation of C. albicans biofilm. Magnoflorine chloride has anti-fungal, anti-antidiabetic and anti-oxidative activity.
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Sarisan
0 ImagesCat. No.: HY-116631CAS No.: 18607-93-7Synonyms: AsaricinSarisan (Asaricin) is a phenolic derivative with antifungal and insecticidal activity. Sarisan can be found in the stem bark of Ocotea opifera Mart..
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Anidulafungin-13C6
0 ImagesCat. No.: HY-13553S1Synonyms: LY303366-13C6Anidulafungin-13C6 (LY303366-13C6) is 13C labeled Anidulafungin. Anidulafungin is a new semisynthetic echinocandin with antifungal potency.
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Octacosamicin A
0 ImagesCat. No.: HY-N14526CAS No.: 122005-25-8Octacosamicin A has the function of resisting bacterium, yeast, and filamentous fungus, but the function of resisting bacterium is weak.
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Antifungal agent 157
0 ImagesCat. No.: HY-185178CAS No.: 2446130-20-5Antifungal agent 157 (Ex.I-339) is a heterocyclyl pyridazine compound and phytopathogenic fungi control agent. Antifungal agent 157 can be used for the research of phytopathogenic fungal infestations.
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Lawsone (Standard)
0 ImagesLawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research.
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Lambertellin
0 ImagesCat. No.: HY-124508CAS No.: 28980-51-0Lambertellin is an effective antibiotic that can be used as a bactericide and as a fungicide. Lambertellin exerts its anti-inflammatory effect in LPS (HY-D1056)-stimulated RAW 264.7 macrophage cells by modulating the activation of the MAPK and NF-κB signaling pathways.
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Oudermansin B
0 ImagesCat. No.: HY-N14898CAS No.: 87081-56-9Oudermansin B is an antibiotic. Oudermansin B acts on fungi to inhibit protein, RNA and DNA synthesis.
