193282-45-0
Chemical Structure
RWJ-49815
- CAS No.: 193282-45-0
- Formula:C30H31N3O
- Molecular Weight:449.59
IUPAC Name: 1-(4-(3,3,3-triphenylpropoxy)phenethyl)guanidine
InChIKey: AJKCPFPHDCULCG-UHFFFAOYSA-N
SMILES: NC(NCCC1=CC=C(OCCC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)=N
Biological Activity: RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor. RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections[1][2].
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RWJ-49815 | RWJ-49815 is a histidine kinase inhibitor. RWJ-49815 inhibits the autokinase activity of purified GST-Sln1 and the autophosphorylation of KinA in vitro. RWJ-49815 acts as a fungal growth inhibitor. RWJ-49815 serves as a bactericide against Gram-positive pathogenic bacteria. RWJ-49815 is applicable to research related to fungal infections and Gram-positive bacterial infections. | |||||||||||||||||||||
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References
- [1]. Deschenes RJ, et al. Antifungal properties and target evaluation of three putative bacterial histidine kinase inhibitors. Antimicrob Agents Chemother. 1999;43(7):1700-1703. [Content Brief]
- [2]. Barrett JF, et al. Antibacterial agents that inhibit two-component signal transduction systems. Proc Natl Acad Sci U S A. 1998 Apr 28;95(9):5317-22. [Content Brief]
