HDAC6 Degrader

PRO-HD2 is a HDAC6 PROTAC degrader. PRO-HD2 exerts antiproliferative activity in leukemia cells. PRO-HD2 can be used for leukemia research.

PROTAC HDAC8 Degrader-5 is a selective HDAC8 PROTAC degrader that mediates ubiquitination and proteasomal degradation through the formation of a ternary complex. PROTAC HDAC8 Degrader-5 degrades HDAC8 with a DC₅₀ of 1.8 nM in MDA-MB-231 cells and a DC₅₀ of 4.7 nM in Jurkat cells. PROTAC HDAC8 Degrader-5 inhibits cancer cell migration and proliferation, induces apoptosis through caspase 3/7 activation, and increases acetylated SMC3 and α-tubulin. PROTAC HDAC8 Degrader-5 is useful for cancer-related research, such as leukemia, triple-negative breast cancer, etc..

PROTAC HDAC6 degrader 5 is a selective HDAC6 PROTAC degrader with an IC₅₀ of 43 nM. PROTAC HDAC6 degrader 5 induces proteasome-dependent degradation of HDAC6 by bridging HDAC6 and CRBN to form a ternary complex. PROTAC HDAC6 degrader 5 is applicable to research related to pulmonary fibrosis.

PROTAC HDAC6 degrader-13 is a selective CRBN-recruiting HDAC6 PROTAC degrader. PROTAC HDAC6 degrader-13 does not affect class I HDACs. PROTAC HDAC6 degrader-13 inhibits TLR-NLRP3 inflammatory signaling. PROTAC HDAC6 degrader-13 is useful for research on acute myeloid leukemia.