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LPL Receptor Related Products (204)
Related Products (204)
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1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA sodium
0 ImagesCat. No.: HY-171906ASynonyms: 1-Arachidonoyl-sn-glycerol 3-phosphate sodium; 1-Arachidonoyl LPA sodium; LPA (20:4) sodium1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) (1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)) is a phospholipid with arachifonic acid at the sn-1 position. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) binds to the LPA2/EDG4 receptor (EC50 of 10 nM). 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can be found in rat brain as 37% of the arachidoinic acid-containing lysophosphatidic acid species. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) is the precursor to 1-arachidonoyl glycerol. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can prevent TNF-α and IL-6 secretion in wild type LPS-stimulated dendritic cells. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) reduces differentiation of HT-29 colon carcinoma cells into goblet cells when sodium butyrate is present.
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BMT-136088
0 ImagesCat. No.: HY-171806CAS No.: 1257213-96-9BMT-136088 is a LPAR1 antagonist. 11C-BMT-136088 can be used as a positron emission tomography (PET) radioligand to quantify specific binding to LPA1 in lung.
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S1P2 antagonist 1
0 ImagesCat. No.: HY-141845CAS No.: 2262402-83-3S1P2 antagonist 1 is an orally bioavailable S1P2 antagonist against fibrotic diseases.
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Fingolimod hydrochloride (Standard)
0 ImagesSynonyms: FTY720 (Standard)Fingolimod (hydrochloride) (Standard) is the analytical standard of Fingolimod (hydrochloride). This product is intended for research and analytical applications. Fingolimod hydrochloride (FTY720), an analog of sphingosine, is a potent sphingosine 1-phosphate (S1P) receptors modulator. Fingolimod hydrochloride is phosphorylated by sphingosine kinases, particularly by SK2, and then binds S1PR1, 3, 4, and 5. Fingolimod hydrochloride induces the internalization of S1P1, and consequently, inhibits S1P activity. Fingolimod hydrochloride also is a pak1 activator.
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L-NASPA ammonium
0 ImagesCat. No.: HY-W040175CAS No.: 799268-44-3L-NASPA ammonium is a ophosphatidic acid (LPA) inhibitor useful in the study of platelet activation.
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Spns2-IN-3
0 ImagesCat. No.: HY-176500CAS No.: 3035022-30-8Sphingolipid E is a synthetic pseudoceramide sphingolipid similar to type 2 ceramide with a metastable lamellar structure. Sphingolipid E ??can be used as a potential drug carrier to control the penetration of molecules as a lipid component of the intercellular space of the stratum corneum.
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(R)-VPC44116
0 ImagesCat. No.: HY-117892ACAS No.: 925978-30-9(R)-VPC44116 is an isomer of VPC44116. VPC44116 is a selective S1P1 receptor antagonist.
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BMS-986020 sodium (Standard)
0 ImagesCat. No.: HY-100619ARCAS No.: 1380650-53-2Synonyms: AM152 sodium (Standard)BMS-986020 (sodium) (Standard) is the analytical standard of BMS-986020 (sodium) (HY-100619A). This product is intended for research and analytical applications. BMS-986020 (AM152) sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 sodium inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 sodium has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).
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W146 (Standard)
0 ImagesCat. No.: HY-101395RCAS No.: 909725-61-7
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JTE-013 (Standard)
0 ImagesJTE-013 (Standard) is the analytical standard of JTE-013. This product is intended for research and analytical applications. JTE-013 is a potent and specific S1P2 (Sphingosine-1-Phosphate 2; EDG-5) antagonist. JTE-013 inhibits the specific binding of radiolabeled S1P to human and rat S1P2 with IC50s of 17 nM and 22 nM, respectively.
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1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA
0 ImagesCat. No.: HY-171906CAS No.: 65446-08-4Synonyms: 1-Arachidonoyl-sn-glycerol 3-phosphate; 1-Arachidonoyl LPA; LPA (20:4)1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid containing arachidonic acid at the sn-1 position. It is a precursor to 1-arachidonoyl glycerol (1-Monoarachidin; HY-130567). 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM. It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS. It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate.
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MK-571 (Standard)
0 ImagesCat. No.: HY-19989RCAS No.: 115104-28-4Synonyms: L-660711 (Standard)MK-571 (Standard) is the analytical standard of MK-571 (HY-19989). This product is intended for research and analytical applications. MK-571 (L-660711) is an orally active, potent and selective competitive leukotriene D4 (LTD4) receptor antagonist, with Ki values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 is also a MRP4 and ABCC1 (MRP1) inhibitor. MK-571 inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.
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Siponimod (Standard)
0 ImagesSynonyms: BAF-312 (Standard)Siponimod (BAF-312) (Standard) is the analytical standard of Siponimod. This product is intended for research and analytical applications. Siponimod is an orally active, blood-brain barrier penetrant dual agonist of S1P1/S1P5, with EC50 values of 0.39 nM and 0.98 nM, respectively. Siponimod induces S1P1 internalization, activates GIRK channels, inhibits lymphocyte egress, reduces peripheral lymphocyte counts, triggers transient bradycardia, prevents synaptic neurodegeneration, promotes remyelination, alleviates demyelination, and prevents the loss of GABAergic interneurons. Siponimod can be used in research related to multiple sclerosis.
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BMS-986020 (Standard)
0 ImagesSynonyms: AM152 (Standard)BMS-986020 (Standard) is the analytical standard of BMS-986020 (HY-100619). This product is intended for research and analytical applications. BMS-986020 (AM152) is a high-affinity and selective lysophosphatidic acid receptor 1 (LPA1) antagonist. BMS-986020 inhibits bile acid and phospholipid transporters with IC50s of 4.8 μM, 6.2 μM, and 7.5 μM for BSEP, MRP4, and MDR3, respectively. BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis (IPF).
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Icanbelimod (Standard)
0 ImagesCat. No.: HY-101265RCAS No.: 1514888-56-2Synonyms: S1p receptor agonist 1 (Standard)Icanbelimod (Standard) is the analytical standard of Icanbelimod (HY-101265). This product is intended for research and analytical applications. Icanbelimod (S1p receptor agonist 1) is a potent and orally active S1P receptor agonist, exhibits an activity of inducing S1P1 internalization (EC50=9.83 nM). Icanbelimod has the potential for the study of arthritis and EAE (experimental autoimmune encephalitis). Icanbelimod is extracted from patent WO2015039587A1, Compound 2.
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H2L5186303 (Standard)
0 ImagesCat. No.: HY-107616RCAS No.: 139262-76-3H2L5186303 (Standard) is the analytical standard of H2L5186303 (HY-107616). This product is intended for research and analytical applications. H2L5186303 is a potent and selective LPA2 receptor antagonist with an IC50 of 9 nM. H2L5186303 promotes Apoptosis. H2L5186303 inhibits cell proliferation and motility. H2L5186303 has anti-inflammatory effects.
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S1P1 agonist 1 (Standard)
0 ImagesCat. No.: HY-104069RCAS No.: 1220973-37-4S1P1 agonist 1 (Standard) is the analytical standard of S1P1 agonist 1 (HY-104069). This product is intended for research and analytical applications. S1P1 Agonist 1 is a S1P1 agonist with immunomodulatory activities.
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Ki16425 (Standard)
0 ImagesSynonyms: Debio 0719 (Standard)Ki16425 (Standard) is the analytical standard of Ki16425. This product is intended for research and analytical applications. Ki16425 (Debio 0719) is a subtype-selective, competitive antagonist of the EDG-family receptors, LPA1 and LPA3 with Kis of 0.34 μM and 0.93 μM, respectively. Ki16425 (Debio 0719) reduces the LPA-induced activation of p42/p44 MAPK. Ki16425 can also inhibit LPA-induced dephosphorylation of Yes-associated protein (YAP)/TAZ in HEK293A cells.
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CYM5442 (Standard)
0 ImagesCat. No.: HY-10968RCAS No.: 1094042-01-9CYM5442 (Standard) is the analytical standard of CYM5442. This product is intended for research and analytical applications. CYM5442 is a potent, highly-selective and orally active sphingosine 1-phosphate (S1P1) receptor agonist with an EC50 of 1.35 nM. CYM5442 is inactive against S1P2, S1P3, S1P4, and S1P5. CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation. CYM5442 exerts retinal neuroprotection. CYM5442 can easily penetrate the central nervous system (CNS).
