Liposome
Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.
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Liposome Related Products (1266)
Related Products (1266)
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Lipid 331
0 ImagesCat. No.: HY-159717Lipid 331 is an ionizable lipid that can be used for the generation of lipid nanoparticles (LNPs). Lipid 331 is a carrier for both siRNA and mRNA.
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YSK 05
0 ImagesYSK 05 is a pH-sensitive cationic lipid. YSK 05 improves the intracellular trafficking of non-viral vectors. YSK 05-MEND shows significantly good gene silencing activity and hemolytic activity. YSK 05 overcomes the suppression of endosomal escape by PEGylation. YSK 05 effectively enhances siRNA delivery both in vitro and in vivo.
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DSPE-N3
0 ImagesDSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical. DSPE-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine
0 ImagesCat. No.: HY-142989CAS No.: 99296-81-81,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is a polyunsaturated phospholipid that serves as a component of lipid monolayers and small unilamellar vesicles. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine can be used to prepare endoplasmic reticulum-targeted liposomes (PERLs), which are composed of 1,2-didocosahexaenoyl-sn-glycero-3-phosphoethanolamine, l-α-phosphatidylinositol and l-α-phosphatidylserine at a molar ratio of 1.5:1.5:1:1. PERLs reduce cholesterol levels in human peripheral blood mononuclear cells (PBMCs) and decrease HIV-1 particle secretion from HIV-1-infected PBMCs. Liposomes formed from 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine exhibit cytotoxicity against leukemia cells. 1,2-Didocosahexaenoyl-sn-glycero-3-phosphocholine is applicable to studies related to hepatitis C virus infection, HIV infection, hepatitis B virus infection and leukemia.
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18:1 DGS-NTA(Ni)
0 Images18:1 DGS-NTA(Ni) is a nickel chelating lipid. 18:1 DGS-NTA(Ni) has high affinity for histidine-tags and can bind histidine tags of recombinant proteins. 18:1 DGS-NTA(Ni) can be used for preparation of liposomes and nanosize multilamellar vesicles (NMVs) which are used in protein and peptide binding studies and antigen delivery.
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244cis
0 Images244cis, a piperazine-containing ionizable cationic lipid, has been used to generate lipid nanoparticles (LNPs). LNPs containing 244cis and coated with mRNA reporter gene were specifically accumulated in mouse lungs compared with LNPs containing SM-102. Induces a decrease in serum chemokine (C-C motif) ligand 2 (CCL2) levels.
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DLin-K-C3-DMA
0 ImagesDLin-K-C3-DMA, a cationic lipid, can be used in the synthesis of nucleic acid-lipid particle to delivery of nucleic acid.
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Dioleyldimethylammonium chloride
0 ImagesCat. No.: HY-W590549CAS No.: 7212-69-3Synonyms: DODACDioleyldimethylammonium chloride (DODAC) is a positively charged lipid promoter with membrane-disrupting activity, which is often formulated into cationic liposomes with dioleoylphosphatidylethanolamine. Dioleyldimethylammonium chloride is used in gene transfection research; through electrostatic interactions, it effectively promotes the binding of programmable fusion vesicles to cells and induces membrane disruption. Dioleyldimethylammonium chloride is also applied in studies on L1210 leukemia and LS180 human colon cancer.
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18:1 PEG2000 PE ammonium
0 ImagesSynonyms: DOPE-PEG2000 ammonium; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium18:1 PEG2000 PE ammonium (DOPE-PEG2000 ammonium) is a polyethyleneglycol/phosphatidyl-ethanolamine conjugate. 18:1 PEG2000 PE ammonium (DOPE-PEG2000 ammonium) can be used for drug delivery.
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FTT5
0 ImagesFTT5 is an ionizable lipid that can be used to prepare lipid nanoparticles for efficient delivery of long-chain mRNA in vivo.
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LNP Lipid-8
0 ImagesCat. No.: HY-154974CAS No.: 2408140-60-1LNP Lipid-8 (11-A-M) is an ionizable single-tail multi-head lipid that can be used as a lipid nanoparticle (LNP) to deliver siRNA to T cells without targeting ligands. LNP Lipid-8 is more selective for T cells than other cell types such as hepatocytes. LNP Lipid-8 selectively delivers siRNA/sgRNA to T cells (especially CD8+ T cells) through endogenous lipid transport pathways, and can enter cells and release RNA through endocytosis to achieve gene silencing. LNP Lipid-8 loaded with GFP siRNA (siGFP) significantly led to GFP gene silencing in mouse models. LNP Lipid-8 showed good efficacy and safety in both cells and animals, without obvious liver targeting and toxicity. LNP Lipid-8 can be used for RNA delivery research in the fields of tumor immunotherapy and T cell-mediated autoimmune diseases.
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DSPE-PEG5000-NHS
0 ImagesCat. No.: HY-W441016DSPE-PEG5000-NHS is a PEG-modified phospholipid derivative that can be used to prepare liposomes. DSPE-PEG5000-NHS is commonly employed as a linker molecule for the surface modification of liposomes to confer targeting capabilities. DSPE-PEG5000-NHS can be used in the study of drug delivery.
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Cholesterol-PEG-Biotin (MW 2000)
0 ImagesCat. No.: HY-W440711Purity: 99.88%Cholesterol-PEG-Biotin (MW 2000) is a pegylated lipids which has strong binding to avidin or streptavidin.
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1-Palmitoyl-sn-glycerol 3-phosphate sodium salt
0 ImagesSynonyms: 1-P-GPA sodium saltPalmitoyl-sn-glycerol 3-phosphate (1-P-GPA) sodium salt is a type of phospholipid and a precursor of lipid membranes. 1-Palmitoyl-sn-glycerol 3-phosphate sodium salt can be incorporated into POPC liposomes, resulting in significant changes in membrane curvature. 1-Palmitoyl-sn-glycerol 3-phosphate sodium salt can induce platelet aggregation, but its activity is 30 times lower than that of 1-hexadecyl-sn-glyceryl-3-phosphate.
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(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium
0 Images(Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol (sodium) is an anionic phospholipid, can be studied for drug delivery and the synthesis of liposomes. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-containing liposomes can induce Tregs that are specific for the liposomes’ cargo. 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol is taken up by antigen-presenting cells mediated via complement component 1q (C1q).
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AA-T3A-C12
0 ImagesAA-T3A-C12 is an anisamide ligand-tethered lipidoid (AA-lipidoid). AA-T3A-C12 mediates great RNA delivery and transfection of activated fibroblasts.
