MALT1
mucosa associated lymphoid tissue lymphoma translocation gene 1
MALT1 is a paracaspase, which is related to the caspase (cysteine-aspartic proteases) family of proteases but cleaves after Arg residues instead of Asp. MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL. MALT1 is a unique paracaspase protein that transduces aberrant oncogenic signaling in ABC-DLBCL. MALT1 represents a potentially important therapeutic target for ABC-DLBCL and MALT lymphoma. MALT1 small molecule inhibitors might be useful chemical tools for studying MALT1 biology and treating MALT1-addicted tumors.
All Product Categories
-
MALT1 Related Products (33)
Related Products (33)
-
Antibodies (1)
- 1
- 2
-
MALT1-IN-3
0 ImagesCat. No.: HY-143422CAS No.: 2504229-63-2
-
(R)-MLT-985
0 ImagesCat. No.: HY-142648ACAS No.: 1832577-07-7(R)-MLT-985 is the R configuration of MLT-985 (HY-142648). MLT-985 is a selective allosteric and orally active MALT1 inhibitor with an IC50 value of 3 nM. MLT-985 can suppress cell growth and aberrant CARD11/BCL10/MALT1 complex signaling. MLT-985 can be used for the research of cancer, such as B cell malignancies.
-
MALT1-IN-13
0 ImagesCat. No.: HY-162268CAS No.: 3032823-58-5MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways.
-
NVS-MALT1
0 ImagesCat. No.: HY-148249CAS No.: 2772439-62-8NVS-MALT1, a chemical probe, is a MALT1 allosteric inhibitor.
-
(S)-MALT1-IN-5
0 ImagesCat. No.: HY-143423ACAS No.: 2434602-25-0(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1).
-
Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone
0 ImagesCat. No.: HY-P4544CAS No.: 1926163-57-6Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.
-
MALT1-IN-8
0 ImagesCat. No.: HY-143426CAS No.: 2244109-29-1MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8).
-
(R)-MALT1-IN-3
0 ImagesCat. No.: HY-143422ACAS No.: 2504229-61-0(R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.
-
MALT1-IN-6
0 ImagesCat. No.: HY-143424CAS No.: 2254669-07-1MALT1-IN-6 is a potent MALT1 protease inhibitor with a Ki of 9 nM. MALT1-IN-6 has anticancer effects (WO2018226150A1; Compound 4).
-
RGT-068A
0 ImagesCat. No.: HY-151805CAS No.: 2577171-33-4
-
MALT1-IN-7
0 ImagesCat. No.: HY-143425CAS No.: 2178993-11-6MALT1-IN-7 (compound 142b) is a potent MALT1 protease inhibitor. MALT1-IN-7 has the potential for cancer research.
-
MALT1-IN-14
0 ImagesCat. No.: HY-164560CAS No.: 3047242-55-4MALT1-IN-14 (comp 2) is a MALT1 inhibitor, with an IC50 of 0.081 μM.
- 1
- 2
