2. Signaling Pathways
  3. Metabolic Enzyme/Protease
    NF-κB
  4. MALT1
  5. MALT1 Degrader

MALT1 Degrader

MALT1 Degraders (3):

Cat. No. Product Name Effect Purity
  • HY-185358
    PROTAC MALT1 Degrader-1
    		Degrader
    PROTAC MALT1 Degrader-1 (Compound 176) is a MALT1 PROTAC degrader. PROTAC MALT1 Degrader-1 is applicable to lymphoma research.
  • HY-179657
    PROTAC MLT Degrader 1
    		Degrader
    PROTAC MLT Degrader 1 (M-PRORAC) is an asymmetric dual-functional degrader based on MLT PROTAC. PROTAC MLT Degrader 1 significantly reduces the protein level of p300 in the cell. PROTAC MLT Degrader 1 can be used in Alzheimer's disease research (pink: MLT ligand (HY-B0075); blue: CRBN ligand (HY-41547); black: linker (HY-140208)).
  • HY-173097
    (S,R,S)-AHPC-Boc derivative 1
    		Degrader 98.56%
    (S,R,S)-AHPC-Boc derivative 1 (Compound 80-9; VH032-Boc derivative 1) is a selective proteasomal degrader targeting MALT1, which recruits the E3 ubiquitin ligase CRBN to form a ternary complex with MALT1, leading to ubiquitination and subsequent proteasomal degradation of MALT1. (S,R,S)-AHPC-Boc derivative 1 inhibits the NF-κB signaling pathway by disrupting the CBM complex, demonstrating potential for inducing apoptosis in ABC-DLBCL cells. (S,R,S)-AHPC-Boc derivative 1 is promising for research of MALT1-dependent cancers, such as diffuse large B-cell lymphoma (DLBCL).