MALT1 Inhibitor
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MALT1-IN-13
0 ImagesCat. No.: HY-162268CAS No.: 3032823-58-5MALT1-IN-13 (compound 10m) is inhibitor for mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), which to binds MALT1 protease covalently and irreversibly, inhibits MALT1 with the IC50 of 1.7 μM. MALT1-IN-13 inhibits proliferation against ABC-DLBCL and induces apoptosis in ABC-DLBCL HBL1. MALT1-IN-13 regulates mTOR and PI3K-Akt pathways.
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NVS-MALT1
0 ImagesCat. No.: HY-148249CAS No.: 2772439-62-8NVS-MALT1, a chemical probe, is a MALT1 allosteric inhibitor.
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(S)-MALT1-IN-5
0 ImagesCat. No.: HY-143423ACAS No.: 2434602-25-0(S)-MALT1-IN-5 is a potent inhibitor of MALT1 protease. (S)-MALT1-IN-5 inhibits the activity of MALT1 is expected to be able to correct the enhancement of MALT1 activity due to abnormality of T cell receptor signal or B cell receptor signal, and cancer or inflammatory disease caused by MALT1 activity is expected. (S)-MALT1-IN-5 has the potential for the research of MALT1-related diseases (extracted from patent WO2020111087A1, compound 1).
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Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone
0 ImagesCat. No.: HY-P4544CAS No.: 1926163-57-6Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone is an irreversible MALT1 protein inhibitor. Z-Val-Arg-Pro-DL-Arg-Fluoromethylketone inhibits the growth and invasion of diffuse large B-cell lymphoma by inhibiting MALT1-induced NF-κB activation and MMP expression.
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MALT1-IN-8
0 ImagesCat. No.: HY-143426CAS No.: 2244109-29-1MALT1-IN-8 is a potent MALT1 protease inhibitor with a IC50 of 2 nM. MALT1-IN-8 inhibits the growth of OCI-LY3 lymphoma cells with an IC50 of 1.16 μM. MALT1-IN-8 has anticancer effects (WO2018165385A1; Compound 8).
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(R)-MALT1-IN-3
0 ImagesCat. No.: HY-143422ACAS No.: 2504229-61-0(R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC50 of 20 nM. (R)-MALT1-IN-3 has IC50 of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively.
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MALT1-IN-6
0 ImagesCat. No.: HY-143424CAS No.: 2254669-07-1MALT1-IN-6 is a potent MALT1 protease inhibitor with a Ki of 9 nM. MALT1-IN-6 has anticancer effects (WO2018226150A1; Compound 4).
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RGT-068A
0 ImagesCat. No.: HY-151805CAS No.: 2577171-33-4
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MALT1-IN-7
0 ImagesCat. No.: HY-143425CAS No.: 2178993-11-6MALT1-IN-7 (compound 142b) is a potent MALT1 protease inhibitor. MALT1-IN-7 has the potential for cancer research.
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MALT1-IN-14
0 ImagesCat. No.: HY-164560CAS No.: 3047242-55-4MALT1-IN-14 (comp 2) is a MALT1 inhibitor, with an IC50 of 0.081 μM.
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