2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. MMP
  5. ADAM10 Isoform
  6. ADAM10 Inhibitor

ADAM10 Inhibitor

ADAM10 Inhibitors (4):

Cat. No. Product Name Effect Purity
  • HY-10293
    Aderbasib
    		Inhibitor 98.09%
    Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17.
  • HY-115670
    GW280264X
    		Inhibitor
    GW280264X is the mixed ADAM10/TACE (ADAM17) metalloproteinases inhibitor.
  • HY-108675
    PPNDS tetrasodium
    		Inhibitor
    PPNDS tetrasodium is a selective and competitive meprin β inhibitor (IC50: 80 nM, Ki: 8 nM), and also inhibits ADAM10 (IC50: 1.2 μM).
  • HY-120852
    JG26
    		Inhibitor
    JG26 is an ADAM17 inhibitor, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM for ADAM8, ADAM17, ADAM10 and MMP-12, respectively.