Monoamine Oxidase
MAO
Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.
Monoamine Oxidase Isoform Specific Products
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Monoamine Oxidase Inhibitors
(476)
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Monoamine Oxidase Activators
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Monoamine Oxidase Modulators
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Monoamine Oxidase Chemicals
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Monoamine Oxidase Substrate
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Monoamine Oxidase Ligands
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Monoamine Oxidase Related Products (511)
Related Products (511)
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Antibodies (2)
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Monoamine Oxidase Isoform Comparison
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DOPR hydrochloride
0 ImagesCat. No.: HY-W725928CAS No.: 53581-55-8Synonyms: 2,5-Dimethoxy-4-propylamphetamine hydrochlorideDOPR hydrochloride is an amphetamine with hallucinogenic properties.
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SZV-558
0 ImagesCat. No.: HY-123556CAS No.: 1648929-13-8SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.
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MAO-A/B-IN-4
0 ImagesCat. No.: HY-175723MAO-A/B-IN-4 is an orally active MAO-A/B inhibitor, with IC50 values of 51.3 μM and 47.0 μM, respectively. MAO-A/B-IN-4 exhibits potent activity against S. aureus, MSSA, MRSA, LRSA, and LREFa. MAO-A/B-IN-4 demonstrates potent antibacterial efficacy in a mouse model of LRSA peritonitis infection. MAO-A/B-IN-4 can be used for the study of bacterial infections.
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DL-Thyroxine
0 ImagesCat. No.: HY-W415287CAS No.: 300-30-1DL-Thyroxine, a thyroid hormone, is a monoamine oxidase inhibitor.
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(±)-Selegiline
0 Images(±)-Selegiline (Deprenyl) is the racemic of Selegiline (HY-14198). Selegiline is a potent, selective and irreversible inhibitor of MAO-B, with an IC50 of 51 nM. Selegiline exhibits 450-flod selectivity for MAO-B over MAO-A (IC50=23 μM). Selegiline can be used for the research of Parkinson's disease, Alzheimer's disease and major depressive disorder.
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Minaprine dihydrochloride (Standard)
0 ImagesCat. No.: HY-B0884ARCAS No.: 25953-17-7Minaprine dihydrochloride (Standard) is the analytical standard of Minaprine dihydrochloride (HY-B0884A). This product is intended for research and analytical applications. Minaprine dihydrochloride is a brain-penetrant monoamine oxidase inhibitor. Minaprine dihydrochloride also weakly inhibits acetylcholinesterase (AChE) activity. Minaprine dihydrochloride reduces intraneuronal dopamine metabolism, lowers striatal homovanillic acid and dihydroxyphenylacetic acid levels, and raises striatal 3-methoxytyramine and 5-hydroxytryptamine levels. Minaprine dihydrochloride exhibits convulsant, antidepressant properties.
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NW-1772
0 ImagesCat. No.: HY-14205CAS No.: 911290-35-2NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases.
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Lilly 51641
0 ImagesLilly 51641 (LY-51641) is a selective and orally active Type A monoamine oxidase inhibitor. Lilly 51641 has the potential for the research of depressed and schizophrenic.
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hMAO-A-IN-1
0 ImagesCat. No.: HY-157392CAS No.: 1039315-88-2hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC50 of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression.
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5-(2-Aminopropyl)indole
0 Images5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.
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Safinamide (Standard)
0 ImagesSynonyms: FCE 26743 (Standard); EMD 1195686 (Standard)Safinamide (Standard) is the analytical standard of Safinamide. This product is intended for research and analytical applications. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
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Brofaromine hydrochloride
0 ImagesCat. No.: HY-105127CAS No.: 63638-90-4Synonyms: CGP 11305A hydrochlorideBrofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.
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Atibeprone
0 ImagesCat. No.: HY-164649CAS No.: 153420-96-3Synonyms: Lu 53439Atibeprone (Lu 53439) is a selective MAO-B inhibitor. Atibeprone has antidepressant activity.
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Norharman-d7
0 ImagesCat. No.: HY-W700241CAS No.: 1216503-21-7Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
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Pargyline (Standard)
0 ImagesPargyline (Standard) is the analytical standard of Pargyline. This product is intended for research and analytical applications. Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities. Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Pirlindole hydrochloride
0 ImagesCat. No.: HY-W279140CAS No.: 16154-78-2Synonyms: Pyrazidole hydrochloride; Pirazidole hydrochloridePirlindole hydrochloride is an orally active, selective and reversible MAO-A inhibitor with an IC50 value of 250 nM. Pirlindole hydrochloride inhibits genomic replication of Enterovirus species B and D, and exhibits moderate activity against enterovirus species A. Pirlindole hydrochloride inhibits MAO-A-mediated monoamine metabolism, promotes adult hippocampal neurogenesis, rescues stress-induced dendritic atrophy of hippocampal granule neurons, reverses behavioral effects associated with chronic mild stress, and also possesses anticonvulsant, analgesic, local anesthetic, hypotensive, antiplatelet aggregation and antispasmodic activities. Pirlindole hydrochloride shows no detectable mutagenic, clastogenic or carcinogenic properties. Pirlindole hydrochloride can be used in research related to depression and enterovirus infections.
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OG-L002 hydrochloride
0 ImagesCat. No.: HY-19333ACAS No.: 1357299-45-6OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 hydrochloride is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 hydrochloride potently inhibits the expression of HSV IE genes.
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GSK-LSD1 dihydrochloride (Standard)
0 ImagesCat. No.: HY-100546ARCAS No.: 2102933-95-7GSK-LSD1 (dihydrochloride) (Standard) is the analytical standard of GSK-LSD1 (dihydrochloride) (HY-100546A). This product is intended for research and analytical applications. GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
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MD 780236 free base
0 ImagesCat. No.: HY-129444CAS No.: 73423-36-6MD 780236 free base is a substrate and selective inhibitor of monoamine oxidase B (MAO-B), competitive with phenylethylamine and 5-hydroxytryptamine (5-HT).
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Safinamide-d5
0 ImagesCat. No.: HY-70057S4Synonyms: FCE 26743-d5; EMD 1195686-d5Safinamide-d5 (FCE 26743-d5) is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 μM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
