SZV-558
SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.
For research use only. We do not sell to patients.
- CAS No.: 1648929-13-8
- Formula: C13H16ClN
- Molecular Weight:221.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
rMAO-B 50 nM (IC50) |
hMAO-B 60 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Sf9 | IC50 |
3500 nM
Compound: 1
|
Inhibition of human recombinant MAO-B expressed in Sf9 cells using 5-phenylacetaldehyde substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
Inhibition of human recombinant MAO-B expressed in Sf9 cells using 5-phenylacetaldehyde substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
|
[PMID: 25627172] |
| Sf9 | IC50 |
60 nM
Compound: 1
|
Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
Inhibition of human recombinant MAO-A expressed in Sf9 cells using 5-hydroxytryptamine substrate assessed as hydrogen peroxide production after 1 hr by fluorescence assay
|
[PMID: 25627172] |
Chemical Information
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CAS No. 1648929-13-8
-
Molecular Weight 221.73
-
Formula C13H16ClN
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SMILES
C#CCN(CC(C1=CC=CC=C1)=C)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)