P2X Receptor Inhibitor
- 1
-
PSFL2915
0 ImagesPSFL2915 is a selective, orally active P2X receptor inhibitor with oral effectiveness, with an IC50 of 0.319 μM for human P2X3, 0.261 μM for rat P2X2/3, and 13.3 μM for human P2X2. PSFL2915 exhibits ~42-fold selectivity over human P2X2. PSFL2915 can be used for the research of chronic cough.
-
P2X3-IN-1
0 ImagesCat. No.: HY-128402CAS No.: 2823331-49-1P2X3-IN-1 (example 7) is an inhibitor of P2X3 receptor. P2X3-IN-1 can be used for neurogenic diseases research.
-
7DG
0 ImagesSynonyms: 7-Desacetoxy-6,7-dehydrogedunin7DG (7-Desacetoxy-6,7-dehydrogedunin) is a PKR inhibitor, P2X7 purinergic receptor inhibitor, and skin-lightening agent. 7DG binds outside the ATP-catalytic domain of PKR, blocks the kinase activity-independent protein-protein interactions of PKR, inhibits the phosphorylation and activity of PKR, disrupts ASC assembly and caspase-1 activation, and suppresses the activation of the NLRP1 inflammasome. 7DG inhibits pyroptosis, suppresses the ATP-P2X7 signaling pathway, and abolishes ATP-induced increases in the expression levels of MITF, tyrosinase, PMEL/gp100, and melanin content. 7DG exerts skin-lightening effects in cultured skin in vitro. 7DG can be used in research related to chronic obstructive pulmonary disease, gout, type 2 diabetes, Alzheimer's disease, and hyperpigmentary skin disorders.
-
P2X7-IN-2 TFA
0 ImagesCat. No.: HY-18725APurity: 99.93%P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease.
-
P2X7-IN-2
0 ImagesCat. No.: HY-18725CAS No.: 1058709-63-9P2X7-IN-2 (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 can be used for the research of autoimmunity, inflammation and cardiovascular disease.
-
Purotoxin 1
0 ImagesCat. No.: HY-P1330CAS No.: 1396322-38-5Purotoxin 1 is a P2X3 receptor inhibitor. Purotoxin 1 shows antinociceptive properties in animal models of inflammatory pain. Purotoxin 1 can be isolated from the venom of the wolf spider Geolycosa sp.
-
NF864
0 ImagesCat. No.: HY-130284CAS No.: 69606-09-3NF864 is a selectivelyP2X1 receptorinhibitor in human platelets.
-
P2X receptor-1
0 ImagesCat. No.: HY-139627CAS No.: 3051864-35-5P2X receptor-1 is a potential inhibitor of P2X receptor for the research of pain and inflammation.
-
Lappaconine
0 ImagesCat. No.: HY-129731CAS No.: 23943-93-3Lappaconine is a diterpenoid alkaloid. Lappaconine can be used for α-hydroxylation of β-oxo esters.
-
TC-P 262
0 ImagesCat. No.: HY-108668CAS No.: 873398-67-5TC-P 262 is a potent P2X3 inhibitor. TC-P 262 shows inhibition by bindings to hP2X3. TC-P 262 has the potential for the research of rheumatoid arthritis, cough, and pain.
- 1
