P2X7-IN-2 TFA
Based on 1 publication(s) in Google Scholar
P2X7-IN-2 TFA (compound 58) is a P2X7 receptor inhibitor. P2X7-IN-2 TFA inhibits IL-Iβ release with an IC50 value of 0.01 nM. P2X7-IN-2 TFA can be used for the research of autoimmunity, inflammation and cardiovascular disease.
For research use only. We do not sell to patients.
- Purity: 99.93%
- Formula: C24H22F7N3O4
- Molecular Weight:549.44
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) P2X7-IN-2 TFA
MoreAll P2X Receptor Isoforms
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Biological Activity
IC50: 0.01 nM (human whole blood IL-Iβ release)[1]
P2X7-IN-2 TFA (0-1 μM;30 min) inhibits human whole blood IL-Iβ release with an IC50 value of 0.01 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 549.44
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Formula C24H22F7N3O4
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Color Off-white to pink
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SMILES
O=C(NC1=C(C)C=CC2=C1C=CN([C@H](C)CN)C2=O)CC3=CC=C(C(F)(F)F)C(F)=C3.O=C(O)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
CGRP alleviates epilepsy via JAK1-STAT1-P2RX7 signaling: a novel neuroprotective axis targeting neuronal damage. [Abstract]2025 Dec 21:170:116080. PMID: 41429063
Solvent & Solubility
DMSO : 100 mg/mL (182.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8200 mL | 9.1002 mL | 18.2003 mL | 45.5009 mL |
| 5 mM | 0.3640 mL | 1.8200 mL | 3.6401 mL | 9.1002 mL | |
| 10 mM | 0.1820 mL | 0.9100 mL | 1.8200 mL | 4.5501 mL | |
| 15 mM | 0.1213 mL | 0.6067 mL | 1.2134 mL | 3.0334 mL | |
| 20 mM | 0.0910 mL | 0.4550 mL | 0.9100 mL | 2.2750 mL | |
| 25 mM | 0.0728 mL | 0.3640 mL | 0.7280 mL | 1.8200 mL | |
| 30 mM | 0.0607 mL | 0.3033 mL | 0.6067 mL | 1.5167 mL | |
| 40 mM | 0.0455 mL | 0.2275 mL | 0.4550 mL | 1.1375 mL | |
| 50 mM | 0.0364 mL | 0.1820 mL | 0.3640 mL | 0.9100 mL | |
| 60 mM | 0.0303 mL | 0.1517 mL | 0.3033 mL | 0.7583 mL | |
| 80 mM | 0.0228 mL | 0.1138 mL | 0.2275 mL | 0.5688 mL | |
| 100 mM | 0.0182 mL | 0.0910 mL | 0.1820 mL | 0.4550 mL |
P2X7-IN-2 TFA Related Classifications
HY-18725A Related Classifications
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